Understanding and Tuning Bioinorganic Interfaces for the Design of Bionanocomposites

Abstract

International audienceInteractions between biological molecules and inorganic species are of tremendous importance in nature. Attempts to create bionanocomposites associating nanoscale inorganic objects with biomolecules face major challenges with regard to controlling their mutual reactivity and preserving their intrinsic properties. This review describes the interactions arising between polyoxometallates or silica particles and biomolecules - including proteins, polysaccharides, lipids and nucleic acids - that depend on physicochemical conditions. It shows that chemical modification of the inorganic and/or bio-organic partner allows fine-tuning of their interface. The specific properties of these bionanocomposites are illustrated, with emphasis on their potential in biotechnology and biomedicine. This field contributes to a better understanding of the ``biochemistry of solids'' and offers an almost unlimited playground for the elaboration of new materials that combine molecular biodiversity with chemistry in its many facets

Multivalent Clustering of Adhesion Ligands in Nanofiber-Nanoparticle Composites

“…[55][56][57][58][59][60] SiNPs are particularly interesting candidates due to their low cost, limited cytotoxicity, ease of synthesis, and the versatility of sol-gel chemistry that offers various routes to conjugate biomolecules at the NP surface, while preserving their molecular recognition properties. 61,62 remix, or adapt this material for any purpose without crediting the original authors. preprint (which was not certified by peer review) in the Public Domain.…”

Multivalent Clustering of Adhesion Ligands in Nanofiber-Nanoparticle Composites

“…[55][56][57][58][59][60] SiNPs are particularly interesting candidates due to their low cost, limited cytotoxicity, ease of synthesis, and the versatility of sol-gel chemistry that offers various routes to conjugate biomolecules at the NP surface, while preserving their molecular recognition properties. 61,62 Here we combine self-assembled PA matrices with SiNPs to design novel SiNP-PA composite biomaterials (Figure 1). The ability to independently modify the chemistries of both PA and NP substrates to link distinct bioactive motifs on which cells would grow allows us to cluster signals in variable patterns positioned through the composite material to impart biological functionality.…”

Multivalent Clustering of Adhesion Ligands in Nanofiber-Nanoparticle Composites

“…Depending on the chemical nature of the nanoparticles (NPs), different properties can be imparted to the resulting composite to design conductive, optical and magnetic devices, and also to tune the mechanical properties and the bioactivity of hydrogels [34,35]. Silica nanoparticles (SiNPs) are particularly interesting candidates due to their low cost, limited cytotoxicity, ease of synthesis, and the versatility of sol-gel chemistry that offers various routes to conjugate biomolecules at the NP surface, while preserving their molecular recognition properties [36,37]. Their incorporation into 3D matrices that refers to the blending strategy defined by Karimi et al [10] makes them very distinct from most studies that have focused on the use of multivalent ligands in 2D planar surface, while most tissues have a 3D structure.…”