Understanding anthelmintic resistance in livestock using “omics” approaches

Mukherjee, Ayan; Kar, Indrajit; Patra, Amlan Kumar

doi:10.1007/s11356-023-31045-y

Cited by 3 publications

(1 citation statement)

References 237 publications

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“…In veterinary medicine, metabolomic research is still limited, although its potential, as previously stated, is widely recognized [18,19].…”

Section: Methodsmentioning

confidence: 99%

Nuclear Magnetic Resonance (NMR) Metabolomics: Current Applications in Equine Health Assessment

Laus,

Bazzano,

Spaterna

et al. 2024

Metabolites

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Metabolomics can allow for the comprehensive identification of metabolites within biological systems, at given time points, in physiological and pathological conditions. In the last few years, metabolomic analysis has gained popularity both in human and in veterinary medicine, showing great potential for novel applications in clinical activity. The aim of applying metabolomics in clinical practice is understanding the mechanisms underlying pathological conditions and the influence of certain stimuli (i.e., drugs, nutrition, exercise) on body systems, in the attempt of identifying biomarkers that can help in the diagnosis of diseases. Proton Nuclear Magnetic Resonance spectroscopy (1H-NMR) is well tailored to be used as an analytical platform for metabolites’ detection at the base of metabolomics studies, due to minimal sample preparation and high reproducibility. In this mini-review article, the scientific production of NMR metabolomic applications to equine medicine is examined. The research works are very different in methodology and difficult to compare. Studies are mainly focused on exercise, reproduction, and nutrition, other than respiratory and musculoskeletal diseases. The available information on this topic is still scant, but a greater collection of data could allow researchers to define new reliable markers to be used in clinical practice for diagnostic and therapeutical purposes.

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“…In veterinary medicine, metabolomic research is still limited, although its potential, as previously stated, is widely recognized [18,19].…”

Section: Methodsmentioning

confidence: 99%

Nuclear Magnetic Resonance (NMR) Metabolomics: Current Applications in Equine Health Assessment

Laus,

Bazzano,

Spaterna

et al. 2024

Metabolites

View full text Add to dashboard Cite

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Saga of anthelmintic resistance: mechanisms of development, methods of detection and ways of mitigation

Pramanik,

Anisuzzaman,

Islam

et al. 2024

Annals of Animal Science

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Nowadays, antimicrobial resistance is a burning issue all over the globe and has been addressed with higher priority. Anthelmintic resistance (AhR) is also becoming a threatening issue since control of helminths mainly depends on deworming using anthelmintics. Therefore, anthelmintics are frequently used around the year. However, the issue regarding AhR has not been focused properly when compared with anti-microbial resistance (AMR). The occurrence of AhR in livestock is very common and increasing rapidly. There are lots of evidences of AhR developed against various anthelmintics. The intensive and indiscriminate use of anthelmintics like benzimidazoles (BMZ), tetrahydropyrimidines (THP) and macrocyclic lactones (MCL) has led to the development of AhR. Therefore, researchers should devise and implement new strategies for helminth control, and control should increasingly incorporate alternative and evidence-based control strategies to limit the development of AhR. This review describes the mechanism of AhR, recent advances in developing resistance, diagnostic tests and worm control strategies.

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Effect of Dietary Benzoic Acid and Oregano Essential Oil as a Substitute for an Anti-Coccidial Agent on Growth Performance and Physiological and Immunological Responses in Broiler Chickens Challenged with Eimeria Species

Khukhodziinai,

Das,

Mukherjee

et al. 2024

Animals

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To overcome the antimicrobial residues in food, benzoic acid (BA) and oregano essential oil (OEO) are used in the broiler chicken industry. Independently, both exerted anticoccidial and antimicrobial actions and improved growth performance in broiler chickens. Their effect may be multiplied when they are used in combination. This present study was carried out to evaluate the efficacy of dietary BA and OEO alone or in combination as a substitute for a commercial coccidiostatic drug on growth performance and physiological and immunological responses in broiler chickens challenged with Eimeria species. A total of 252 unsexed 1-day-old broiler chicks were equally allotted to 36 pens, each pen containing seven chicks. The pens were randomly assigned to six treatments with six pens (replicates) for each treatment (n = 6)—(i) negative control, (ii) positive control, coccidia-challenged and non-treated, (iii) supplemented with salinomycin (an anti-coccidial drug) at 60 mg/kg of feed and coccidia-challenged, (iv) supplemented with BA at 500 mg/kg of feed and coccidia-challenged, (v) supplemented with OEOat 500 mg/kg of feed and coccidia-challenged (OEO), and (vi) supplemented with BA at 500 mg/kg of feed and OEO at 500 mg/kg of feed and coccidia-challenged (B&O). The liver enzymes and thyroxine and creatinine levels were not affected (p > 0.05) both in coccidia-challenged and supplemented chickens. The BA and OEO applied separately or in combination (B&O) significantly (p < 0.05) reduced gut pathogenic bacteria (Salmonella and Escherichia coli) and Eimeria spp., and concurrently enhanced (p > 0.05) the Lactobacillus population with better body weight gain, improved feed utilization, and superior hematological values. It also up-regulated (p > 0.05) the interferon-γ gene expression and down-regulated (p < 0.05) the interleukin-10 and Toll-like receptor-4 gene expression to protect the chickens from inflammatory reactions, which were not demonstrated in salinomycin-treated birds. The B&O supplementation increased (p < 0.05) the immune system by enhancing Eimeria-specific immunoglobulin Y titer and lymphocyte proliferation response. This study suggests that the combined application of OEO and BA can substitute for a commercial anti-coccidial agent (salinomycin) in controlling coccidiosis as well as improving growth performance, gut health, and immune responses in broiler chickens with a means of antimicrobial-resistant free food products.

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Understanding anthelmintic resistance in livestock using “omics” approaches

Cited by 3 publications

References 237 publications

Nuclear Magnetic Resonance (NMR) Metabolomics: Current Applications in Equine Health Assessment

Nuclear Magnetic Resonance (NMR) Metabolomics: Current Applications in Equine Health Assessment

Saga of anthelmintic resistance: mechanisms of development, methods of detection and ways of mitigation

Effect of Dietary Benzoic Acid and Oregano Essential Oil as a Substitute for an Anti-Coccidial Agent on Growth Performance and Physiological and Immunological Responses in Broiler Chickens Challenged with Eimeria Species

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