Understanding arrhythmogenic right ventricular cardiomyopathy

Abstract

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiac disease characterized by fibrofatty replacement of myocardial tissue and is an important cause of ventricular dysrhythmias, ventricular dysfunction, and sudden cardiac death. The clinical course and genetics of this condition are highly variable, and definitive diagnosis can be challenging, despite published diagnostic criteria. Recognizing symptoms and risk factors for ventricular dysrhythmias is key to managing affected patients and family members. High-intensity and endurance exercise is widely known to increase disease expression and progression; however, a safe exercise regimen remains uncertain, and a personalized approach to management should be considered. This article reviews the incidence, pathophysiology, diagnostic criteria, and treatment considerations for ARVC.

An Unexpected Case of Severe Arrhythmogenic Right Ventricular Cardiomyopathy

“…Symptoms include lightheadedness, palpitations, or syncope caused by ventricular arrhythmias. Advanced cases present with heart failure symptoms such as dyspnea on exertion and volume overload [4]. Our patient demonstrated symptoms on the lighter end of the spectrum despite having a notable decrease in cardiac function.…”

Evaluating Catheter Ablation Versus Conventional Management for Ventricular Arrhythmias in Arrhythmogenic Right Ventricular Cardiomyopathy: A Five-Year Retrospective Cohort Study

“…Arrhythmogenic right ventricular cardiomyopathy (ARVC) represents a unique clinical challenge characterized by the progressive replacement of right ventricular myocardial tissue with fibro-fatty material. This genetic disorder is a notable cause of ventricular arrhythmias and sudden cardiac death, especially in young adults and athletes, making it a focal point of cardiovascular research and clinical intervention strategies [1,2]. Despite considerable advancements in understanding ARVC's genetic underpinnings and clinical manifestations, the pathophysiology and disease progression remain incompletely elucidated, complicating effective management and treatment [3,4].…”