Understanding cancer and its treatment in Thai traditional medicine: An ethnopharmacological-anthropological investigation

Lumlerdkij, Natchagorn; Tantiwongse, Jaturapat; Booranasubkajorn, Suksalin; Boonrak, Ranida; Akarasereenont, Pravit; Laohapand, Tawee; Heinrich, Michael

doi:10.1016/j.jep.2018.01.029

Cited by 25 publications

(17 citation statements)

References 95 publications

(91 reference statements)

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“…Medicinal plants have a long history of being used to treat various types of cancer. For example, numerous Asian countries, such as China, Japan and Thailand, have used traditional medicinal plants to treat cancer for thousands of years (8)(9)(10). Several of the antineoplastic drugs that have been used in a clinical setting originate from plants, some of which have significantly prolonged the survival time of patients.…”

Section: Natural Products As Antitumor Drugsmentioning

confidence: 99%

Ailanthone: A novel potential drug for treating human cancer (Review)

Ding

Chen

et al. 2020

Oncol Lett

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Cancer is the second leading cause of death after cardiovascular disease. In 2015, >8.7 million people died worldwide due to cancer, and by 2030 this figure is expected to increase to ~13.1 million. Tumor chemotherapy drugs have specific toxicity and side effects, and patients can also develop secondary drug resistance. To prevent and treat cancer, scientists have developed novel drugs with improved antitumor effects and decreased toxicity. Ailanthone (AIL) is a quassinoid extract from the traditional Chinese medicine plant Ailanthus altissima , which is known to have anti-inflammatory and antimalarial effects. An increasing number of studies have focused on AIL due to its antitumor activity. AIL can inhibit cell proliferation and induce apoptosis by up- or downregulating cancer-associated molecules, which ultimately leads to cancer cell death. Antitumor effects of AIL have been observed in melanoma, acute myeloid leukemia, bladder, lung, breast, gastric and prostate cancer and vestibular neurilemmoma. To the best of our knowledge, the present study is the first review to describe the antitumor mechanisms of AIL.

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Section: Natural Products As Antitumor Drugsmentioning

confidence: 99%

Ailanthone: A novel potential drug for treating human cancer (Review)

Ding

Chen

et al. 2020

Oncol Lett

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“…The use of Thai traditional herbs, particularly their phytochemicals, has been reported to exert broad-spectrum activities as the anticancer, anti-in ammatory, antioxidant therapeutics, and antivirals. [18][19][20][21] This suggests their potential as the anti-SARS-CoV-2 candidates.…”

Section: Introductionmentioning

confidence: 99%

High-Content Screening of Thai Medicinal Plants Reveals Boesenbergia rotunda Extract and its Component Panduratin A as Anti-SARS-CoV-2 Agents

Kanjanasirirat

Suksatu

Manopwisedjaroen

et al. 2020

Preprint

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Since December 2019, the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused severe pneumonia, a disease named COVID-19, that became pandemic and created an acute threat to public health. The effective therapeutics are in urgent need. Here, we developed a high-content screening for the antiviral candidates using fluorescence-based SARS-CoV-2 nucleoprotein detection in Vero E6 cells coupled with plaque reduction assay. Among 122 Thai natural products, we found that Boesenbergia rotunda extract and its phytochemical compound, panduratin A, exhibited the potent anti-SARS-CoV-2 activity. Treatment with B. rotunda extract and panduratin A after viral infection drastically suppressed SARS-CoV-2 infectivity in Vero E6 cells with IC50 of 3.62 μg/mL (CC50 = 28.06 µg/mL) and 0.81 μΜ (CC50=14.71 µM), respectively. Also, the treatment of panduratin A at the pre-entry phase inhibited SARS-CoV-2 infection with IC50 of 5.30 µM (CC50=43.47 µM). Our study demonstrated, for the first time, that panduratin A exerts the inhibitory effect against SARS-CoV-2 infection at both pre-entry and post-infection phases. Since B. rotunda is a culinary herb generally grown in China and Southeast Asia, its extract and the purified panduratin A may serve as the promising candidates for therapeutic purposes with economic advantage during COVID-19 situation.

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“…Apart from FDA-approved drugs, natural product-based medicines are gained much attention. The use of Thai traditional herbs, particularly their phytochemicals, has been reported to exert broad-spectrum activities as the anticancer, anti-inflammatory, antioxidant therapeutics, and antivirals [17][18][19][20] . This suggests their potential as the anti-SARS-CoV-2 candidates.…”

mentioning

confidence: 99%

High-content screening of Thai medicinal plants reveals Boesenbergia rotunda extract and its component Panduratin A as anti-SARS-CoV-2 agents

Kanjanasirirat

Suksatu

Manopwisedjaroen

et al. 2020

Sci Rep

125

108

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Since December 2019, the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused severe pneumonia, a disease named COVID-19, that became pandemic and created an acute threat to public health. The effective therapeutics are in urgent need. Here, we developed a high-content screening for the antiviral candidates using fluorescence-based SARS-CoV-2 nucleoprotein detection in Vero E6 cells coupled with plaque reduction assay. Among 122 Thai natural products, we found that Boesenbergia rotunda extract and its phytochemical compound, panduratin A, exhibited the potent anti-SARS-CoV-2 activity. Treatment with B. rotunda extract and panduratin A after viral infection drastically suppressed SARS-CoV-2 infectivity in Vero E6 cells with IC50 of 3.62 μg/mL (CC50 = 28.06 µg/mL) and 0.81 μΜ (CC50 = 14.71 µM), respectively. Also, the treatment of panduratin A at the pre-entry phase inhibited SARS-CoV-2 infection with IC50 of 5.30 µM (CC50 = 43.47 µM). Our study demonstrated, for the first time, that panduratin A exerts the inhibitory effect against SARS-CoV-2 infection at both pre-entry and post-infection phases. Apart from Vero E6 cells, treatment with this compound was able to suppress viral infectivity in human airway epithelial cells. This result confirmed the potential of panduratin A as the anti-SARS-CoV-2 agent in the major target cells in human. Since B. rotunda is a culinary herb generally grown in China and Southeast Asia, its extract and the purified panduratin A may serve as the promising candidates for therapeutic purposes with economic advantage during COVID-19 situation.

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Understanding cancer and its treatment in Thai traditional medicine: An ethnopharmacological-anthropological investigation

Cited by 25 publications

References 95 publications

Ailanthone: A novel potential drug for treating human cancer (Review)

Ailanthone: A novel potential drug for treating human cancer (Review)

High-Content Screening of Thai Medicinal Plants Reveals Boesenbergia rotunda Extract and its Component Panduratin A as Anti-SARS-CoV-2 Agents

High-content screening of Thai medicinal plants reveals Boesenbergia rotunda extract and its component Panduratin A as anti-SARS-CoV-2 agents

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