Understanding Cancer Invasion and Metastasis

Identification of cancer-associated fibroblast-related Ectodysplasin-A as a novel indicator for prognosis and immune response in gastric cancer

“…Recent research has found that TGFβ is able to induce EDA, which binds to TGF-β1 and triggers the enhancement of α-SMA (α-actinin-2) and fibroblast contraction, thereby inducing fibroblast and ECM contraction function [ 26 ]. Activation of Wnt signaling can be achieved by the EDA-EDAR pathway, which serves as a canonical effector of cell development and cancer progression.…”