Monosodium Glutamate (MSG), constitutes a few of the most commonly encountered additives in processed foodstuffs. Its use has grown throughout the years, and consumers are able to recognise it in a wide variety of processed products, as well as ingredients at any stall or grocery shop. Several investigations have challenged its long-term safety, despite the fact it is usually acknowledged as safe by organisations that oversee food safety. The present review details the impact of MSG on gut health and other complications. Increased MSG consumption, and its potential effects on the gastrointestinal system involving glutamatergic neuronal transmission, inflammatory mediators, and gut microbiota have been reviewed in this article. This narrative review has been performed from January 2023 to June 2023 using the literature obtained from databases like Scopus, PubMed, and other databases of The National Library of Medicine, USA. This review may provide further insights into safety issues related to MSG and its use as a food additive or ingredient.