Understanding complex host-microbe interactions in
 Hydra

Bosch, Thomas C. G.

doi:10.4161/gmic.20660

Cited by 37 publications

(26 citation statements)

References 50 publications

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“…Thus, Hydra spp. provide the opportunity to study the immune response of ectodermal and endodermal cells 62 . General features of the cnidarian immune response include AMPs, PRRs and a signalling cascade related to the nuclear factor-κB pathway (NF-κB pathway) 63 .…”

Section: Bacterial Symbiosis In Hydra Sppmentioning

confidence: 99%

Knowing your friends: invertebrate innate immunity fosters beneficial bacterial symbioses

Nyholm

Graf²

2012

Nat Rev Microbiol

195

156

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The innate immune system is present in all animals and is a crucial first line of defence against pathogens. However, animals also harbour large numbers of beneficial microorganisms that can be housed in the digestive tract, in specialized organs or on tissue surfaces. Although invertebrates lack conventional antibody-based immunity, they are capable of eliminating pathogens and, perhaps more importantly, discriminating them from other microorganisms. This Review examines the interactions between the innate immune systems of several model invertebrates and the symbionts of these organisms, and addresses the central question of how these long-lived and specific associations are established and maintained.

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Section: Bacterial Symbiosis In Hydra Sppmentioning

confidence: 99%

Knowing your friends: invertebrate innate immunity fosters beneficial bacterial symbioses

Nyholm

Graf²

2012

Nat Rev Microbiol

195

156

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“…Unlike most animal systems, it is possible to examine temporal bacterial profiles of clonal lineages without being limited to fecal samples, as Hydra grows clonally under constant laboratory conditions. Hydra's tube-like body ( Figure 1a) resembles in several aspects the anatomy of the vertebrate intestine with the endodermal epithelium lining the gastric cavity and the ectodermal epithelium providing a permanent protective barrier to the environment (Bosch, 2012). Changes in Hydra's epithelial homeostasis cause significant changes in the microbial community , implying a direct interaction between epithelia and microbiota.…”

Section: Introductionmentioning

confidence: 99%

Bacterial colonization of Hydra hatchlings follows a robust temporal pattern

et al. 2013

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Animals are colonized by complex bacterial communities. The processes controlling community membership and influencing the establishment of the microbial ecosystem during development are poorly understood. Here we aimed to explore the assembly of bacterial communities in Hydra with the broader goal of elucidating the general rules that determine the temporal progression of bacterial colonization of animal epithelia. We profiled the microbial communities in polyps at various time points after hatching in four replicates. The composition and temporal patterns of the bacterial communities were strikingly similar in all replicates. Distinct features included high diversity of community profiles in the first week, a remarkable but transient adult-like profile 2 weeks after hatching, followed by progressive emergence of a stable adult-like pattern characterized by low species diversity and the preponderance of the Betaproteobacterium Curvibacter. Intriguingly, this process displayed important parallels to the assembly of human fecal communities after birth. In addition, a mathematical modeling approach was used to uncover the organizational principles of this colonization process, suggesting that both, local environmental or host-derived factor(s) modulating the colonization rate, as well as frequency-dependent interactions of individual bacterial community members are important aspects in the emergence of a stable bacterial community at the end of development.

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“…Rahat and Dimentman [42] showed that bacteria might be important for tissue proliferation and successful budding in Hydra; therefore, the innate immune system in Hydra needs to distinguish between beneficial symbionts and pathogens. This indicates that the innate immune system shapes the interaction between Hydra and microbiota [43]. Furthermore, they observed the same species-specific bacterial community between individuals captured in a natural pond and individuals that had been kept in laboratory conditions for 30 years [44].…”

Section: Maintenance Of High Cell Renewal and Turnover Ratesmentioning

confidence: 91%

Aging and Potential for Self-Renewal: Hydra Living in the Age of Aging - A Mini-Review

Schaible

Sussman²,

Kramer³

2014

Gerontology

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Hydra present an interesting deviation from typical life histories: they have an extensive capacity to regenerate and self-renew and seem to defy the aging process. Hydra have the ability to decouple the aging process from their life history and therefore provide us with a unique opportunity to gain insight into the aging process not only for basal hydrozoans but also for other species across the tree of life. We argue that under steady feeding and asexual reproduction Hydra species are able to escape aging as a result of high levels of cell proliferation and regenerative ability. We further highlight cellular processes for stem cell maintenance, such as the telomere dynamic, which prevent the accumulation of damage and protect against diseases and pathogens that mediate this condition. In addition, we discuss the causes of aging in other Hydra species.

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Understanding complex host-microbe interactions in Hydra

Cited by 37 publications

References 50 publications

Knowing your friends: invertebrate innate immunity fosters beneficial bacterial symbioses

Knowing your friends: invertebrate innate immunity fosters beneficial bacterial symbioses

Bacterial colonization of Hydra hatchlings follows a robust temporal pattern

Aging and Potential for Self-Renewal: <b><i>Hydra</i></b> Living in the Age of Aging - A Mini-Review

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