Due to the significant impact of criminality on the quality of life in a particular territory, criminality is attracting more and more attention from local authorities which are trying to reduce it. In this respect, the concept of CPTED (Crime Prevention Through Environmental Design) which is quite often used outside of Slovakia and is based on prevention of criminality through the appropriate design of urban environments, seems to be useful. The study offers the characteristics of CPTED principles and also suggests possibilities for its application within inner-city criminality on model territories of the city of Prešov (Slovakia) as an usable way of reducing crime in other mainly East-central European cities.