Understanding delusions

Kiran, Chandra; Chaudhury, Suprakash

doi:10.4103/0972-6748.57851

Cited by 64 publications

(32 citation statements)

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“…Delusions were characterised according to their content and following accepted criteria (Kiran and Chaudhury, 2009). Persecutory delusions were the most common and were present in 63% of all affected patients.…”

Section: Resultsmentioning

confidence: 99%

The neural correlates and clinical characteristics of psychosis in the frontotemporal dementia continuum and the C9orf72 expansion

Devenney

Landín-Romero

Irish

et al. 2017

NeuroImage: Clinical

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ObjectiveThis present study aims to address the gap in the literature regarding the severity and underlying neural correlates of psychotic symptoms in frontotemporal dementia with and without the C9orf72 gene expansion.MethodsFifty-six patients with behavioural variant frontotemporal dementia (20 with concomitant amyotrophic lateral sclerosis) and 23 healthy controls underwent neuropsychological assessments, detailed clinical interview for assessment of psychosis symptoms, brain MRI and genetic testing. Carers underwent a clinical interview based upon the neuropsychiatric inventory. Patients were assessed at ForeFront, the Frontotemporal Dementia Research Group at Neuroscience Research Australia or at the Brain and Mind Centre, between January 2008 and December 2013.An index of psychosis was calculated, taking into account the degree and severity of psychosis in each case. Voxel-based morphometry analyses were used to explore relationships between the psychosis index and grey matter changes.ResultsThirty-four percent of frontotemporal dementia patients showed psychotic features. C9orf72 expansion cases were more likely to exhibit psychotic symptoms than non-carriers (64% vs. 26%; p = 0.006), which were also more severe (psychotic index 23.1 vs. 8.1; p = 0.002). Delusions comprised persecutory, somatic, jealous and grandiose types and were present in 57% of C9orf72 carriers and 19% of non-carriers (p = 0.006). Auditory, visual or tactile hallucinations were present in 36% of C9orf72 carriers and 17% of non-carriers (p = 0.13). Increased psychotic symptoms in C9orf72 expansion carriers correlated with atrophy in a distributed cortical and subcortical network that included discrete regions of the frontal, temporal and occipital cortices, as well as the thalamus, striatum and cerebellum.ConclusionsThis study underlines the need to consider and assess for psychotic symptoms in the frontotemporal dementia-amyotrophic lateral sclerosis continuum particularly in those with C9orf72 gene expansions. The network of brain regions identified in this study is strikingly similar to that identified in other psychotic disorders such as schizophrenia, which suggests that treatment strategies in psychiatry may be beneficial for the management of psychotic symptoms in frontotemporal dementia.

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Section: Resultsmentioning

confidence: 99%

The neural correlates and clinical characteristics of psychosis in the frontotemporal dementia continuum and the C9orf72 expansion

Devenney

Landín-Romero

Irish

et al. 2017

NeuroImage: Clinical

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“…Chaudhury and Kiran nicely summarize this historical approach to this classification issue, and provide the proposition that "an intellectual sleight of hand is often in operation in the distinction of overvalued and delusion-like. If we intend to make a 'psychotic' diagnosis, then the belief is delusion-like; if we intend to make a 'non-psychotic' diagnosis, then the belief is overvalued" (Chaudhury and Kiran 2009).…”

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confidence: 99%

The anti-vaccination movement: when does a belief become delusional?

Fusick

Gunther

Sullivan

2020

J Public Health (Berl.)

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“…Kretschmer’s main purpose was to identify particular patterns that could eventually lead to delusional states. Kretschmer can be recognized as a pioneer, introducing the concept of “multidimensional psychiatry”, taking into account biological and biographical factors [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 related lockdown: a trigger from the pre-melancholic phase to catatonia and depression, a case report of a 59 year-old man

et al. 2020

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Background The pre-melancholic model described by Tellenbach may provide a common model for understanding the psychological implications of the lockdown. In this case report, we describe a rare catatonic status as a psychological implication linked to the COVID-19 pandemic, a really unique global situation. Case presentation B is a 59 year-old man with mute psychiatric anamnesis whose mother suffered from a major depressive disorder. As the lockdown began, he started to develop concerns about his family’s economic condition. According to his wife, he could see no end to the epidemic and no future at all. Moving from this, he started to show a severe and rapidly progressive depression and to develop mood congruent delusions. In addition, he had increasing anhedonia, apathy, starvation and insomnia. This turned in the end into a catatonic-like state, along with a deep desire to die. Admitted to the psychiatry ward in a state of mutism, he was discharged after 15 days with a diagnosis of “Major depressive disorder, single severe episode with no psychotic behavior”. He was treated with Sertraline, Olanzapine and Lorazepam. Conclusions Our aim is to draw attention to the effect of the lockdown upon a Tellenbach-like personality structure. Identifying this type of pre-morbid personality structure could help clinicians understand and treat some cases of patients with severe major depressive disorders elicited by the COVID-19 pandemic.

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Understanding delusions

Cited by 64 publications

References 0 publications

The neural correlates and clinical characteristics of psychosis in the frontotemporal dementia continuum and the C9orf72 expansion

The neural correlates and clinical characteristics of psychosis in the frontotemporal dementia continuum and the C9orf72 expansion

The anti-vaccination movement: when does a belief become delusional?

COVID-19 related lockdown: a trigger from the pre-melancholic phase to catatonia and depression, a case report of a 59 year-old man

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