Understanding Financial Conflicts of Interest

Thompson, Dennis F.

doi:10.1056/nejm199308193290812

Cited by 742 publications

(423 citation statements)

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“…As defined by The Endocrine Society, a duality of interest is present when two or more interests are potentially in conflict, while a conflict of interest exists when a given relationship or practice gives rise to two or more contradictory interests [2]. Specifically, Thompson describes conflict of interest as 'a set of conditions in which professional judgement concerning a primary interest (such as patient welfare or the validity of research) tends to be unduly influenced by a secondary interest (such as financial gain)' [3]. The dualities of interest listed for authors of the present guidelines include research grants, serving on scientific advisory boards and receipt of honoraria for speaking engagements [1].…”

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confidence: 99%

Guidelines for medical management of hyperglycaemia in type 2 diabetes and duality of interest

Eizirik

2008

Diabetologia

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Guidelines for medical management of hyperglycaemia in type 2 diabetes and duality of interest

Eizirik

2008

Diabetologia

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“…Conflicts of interest may be defined as Bcircumstances that create a risk that professional judgments or actions regarding a primary interest will be unduly influenced by a secondary interest^ [5,6]. Broadly stated, the primary duty of the investigator in medical research is to obtain scientifically valid results, while promoting and protecting the integrity of research.…”

Section: What Are Conflicts Of Interest?mentioning

confidence: 99%

“…Secondary financial interests are the focus of most conflict of interest policies [4][5][6]15]. The attention to financial gain has been justified by the recognition that financial interests are Bmore objective, fungible, and quantifiable^than other secondary interests [5] and are thus easier to regulate fairly and effectively than less tangible incentives [6].…”

Section: What Are Conflicts Of Interest?mentioning

confidence: 99%

Conflicts of interest in research: looking out for number one means keeping the primary interest front and center

Romain

2015

Curr Rev Musculoskelet Med

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Conflicts of interest represent circumstances in which professional judgments or actions regarding a primary interest, such as the responsibilities of a medical researcher, may be at risk of being unduly influenced by a secondary interest, such as financial gain or career advancement. The secondary interest may be financial or non-financial, and the resultant bias may be conscious or unconscious. The presence of conflicts of interest poses a problem for professional, patient, and public trust in research and the research enterprise. Effective means of identifying and managing conflicts are an important element in successfully achieving the goals of research. These strategies typically focus on the investigator and rely upon disclosure, which has substantial limitations. Additional management strategies include process-oriented steps and outcomes-oriented strategies. More attention to identifying and managing non-financial conflicts is needed. Future empirical research will be important for defining which conflicts need to be better addressed and how to achieve this goal.

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“…Moreover, when a scientist has obtained public grants in a specific research area in the past, this may automatically lead to a heightened interest in securing more funding in this branch of research. Thus, it is not surprising that publicly visible assessments of potential hazards and risks, e.g., the 'endocrine disruptors' (Solecki et al 2016), often end with a description of A definition of the term 'conflict of interest' was suggested by Dennis Thompson in (1993) and can still be considered valid: 'A conflict of interest is a set of circumstances that creates a risk that professional judgement or actions regarding a primary interest will be unduly influenced by a secondary interest' (Thompson 1993). Today, the 'circumstances' from Thompson's definition have been restricted almost exclusively to funding or payment from industry.…”

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confidence: 99%