Understanding flow patterns and inflammatory status in intracranial aneurysms: Towards a personalized medicine

Berge, Jérôme; Blanco, Patrick; Rooryck, Caroline; Boursier, Romain; Marnat, Gaultier; Gariel, Florent; Wavasseur, Thomas; Desal, Hubert; Dousset, V.

doi:10.1016/j.neurad.2015.09.005

Cited by 16 publications

(18 citation statements)

References 47 publications

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“…The significantly different patterns of WSS between recurrent and nonrecurrent aneurysms in our study are very much in line with what we know about aneurysm growth and rupture in untreated aneurysms: It is state‐of‐the‐art knowledge that both high and low WSS play an important role in the initiation, growth and rupture of aneurysms . The physiological basis is that intensified WSS leads to overexpression of Nitric oxide and, therefore, a nonphysiological arterial tone that destroys the endothelium.…”

Section: Resultssupporting

confidence: 87%

Hemodynamic Differences Between Recurrent and Nonrecurrent Intracranial Aneurysms: Fluid Dynamics Simulations Based on MR Angiography

Schönfeld

Forkert

Fiehler

et al. 2019

Journal of Neuroimaging

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Although the role of wall shear stress (WSS) in the initiation, growth, and rupture of intracranial aneurysms has been well studied, its influence on aneurysm recurrence after endovascular treatment requires further investigation. We aimed to compare WSS at necks of recurrent and nonrecurrent aneurysms. METHODS: Nine recurrent coil-embolized aneurysms were identified and matched with nine nonrecurrent aneurysms. Patientspecific vessel geometries reconstructed from follow-up 3-D time-of-flight magnetic resonance angiography were analyzed using computational fluid dynamics (CFD) simulations. Absolute WSS and the percentage of abnormally low and high WSS at the aneurysm neck compared to the near artery were measured. RESULTS: The median percentage of abnormal WSS at the aneurysm neck was 49.3% for recurrent and 34.7% for nonrecurrent aneurysms (P = .011). The area under the receiver-operating-characteristic curve for distinguishing these aneurysms according to the percentage of abnormal WSS was .86 (95% CI .62 to .98). The optimal cut-off value of 45.1% resulted in a sensitivity and a specificity of 88.89% (95% CI 51.8% to 99.7%). CONCLUSION:Our findings indicate that necks of recurrent aneurysms are exposed to abnormal WSS to a larger extent. Abnormal WSS may serve as a metric to distinguish them from nonrecurrent aneurysms with CFD simulations a priori.

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Section: Resultssupporting

confidence: 87%

Hemodynamic Differences Between Recurrent and Nonrecurrent Intracranial Aneurysms: Fluid Dynamics Simulations Based on MR Angiography

Schönfeld

Forkert

Fiehler

et al. 2019

Journal of Neuroimaging

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“…Moreover, the prevalence of IA is the highest among people at the age of 30 to 60 years old, while the incidence of IA between males and females is 1:2 . As a more serious outcome of IA, subarachnoid haemorrhage (SAH) is caused by the rupture of IA and can lead to death in up to 30% IA patients due to ubarachnoid hemorrhage consequences . Indeed, 85% of spontaneous SAH is caused by the rupture of IA.…”

Section: Introductionmentioning

confidence: 99%

“…1 As a more serious outcome of IA, subarachnoid haemorrhage (SAH) is caused by the rupture of IA and can lead to death in up to 30% IA patients due to ubarachnoid hemorrhage consequences. 4,5 Indeed, 85% of spontaneous SAH is caused by the rupture of IA.…”

Section: Introductionmentioning

confidence: 99%

A functional polymorphism in the promoter region of miR‐155 predicts the risk of intracranial hemorrhage caused by rupture intracranial aneurysm

Yang

Peng

Pang

et al. 2019

J of Cellular Biochemistry

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Background This study aimed to study the effect and underlying molecular mechanisms of single‐nucleotide polymorphism (SNP) rs767649 during the pathogenesis of intracranial aneurysm (IA) rupture. Method Real‐time PCR and Western blot analysis were performed to detect the differentiated expression of miR‐155 and matrix metalloproteinase‐2 (MMP‐2) among different sample groups. Computational analysis and luciferase assay were conducted to study the effect of SNP rs767649 on the expression of miR‐155 as well as the regulatory relationship between miR‐155 and MMP‐2. Results In unruptured IA samples, the expression of miR‐155 was upregulated while the expression of MMP‐2 was downregulated compared with the ruptured IA samples. Similarly, the expression of miR‐155 was upregulated while the expression of MMP‐2 was downregulated in samples genotyped as AA/AT compared with samples genotyped as TT. In addition, compared with the negative controls, the luciferase activities of cells treated with rs767649A and rs767649T were both elevated with rs767649A‐transfected cells expressing the highest luciferase activity. Furthermore, a negative relationship was established between miR‐155 and MMP‐2 by measuring the luciferase activity of cells cotransfected with miR‐155 and the wild‐type 3′‐untranslated region of MMP‐2. Conclusion The results of this study showed that the SNP rs767649 in the promoter of miR‐155 could reduce the transcription activity of miR‐155, while poorly expressed miR‐155 could increase the incidence of IA rupture by increasing the expression of MMP‐2, especially in subjects carrying the TT genotype of SNP rs767649.

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“…It is an important component type of atherosclerosis, accounting for 70-80% of all patients with stroke. In cerebral thrombosis, ~90% of cases develop on the basis of cerebral atherosclerosis (2). Therefore, it is frequently referred to as atherosclerotic cerebral thrombosis.…”

Section: Introductionmentioning

confidence: 99%

“…Among these, the coronary artery and cerebral arteries are the most dominant (3). Furthermore, the lesion predominantly involves multiple organs at the same time (2). With the increase in detailed investigations on atherosclerosis over the last century, several representative theories have formed successively.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑634 alters nerve apoptosis via the PI3K/Akt pathway in cerebral infarction

et al. 2018

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In the present study, the role and mechanism of microRNA‑634 (miRNA‑634) in the adjustment of nerve inflammation and apoptosis in cerebral infarction were investigated. In a cerebral infarction rat model, the expression of miRNA‑634 was increased, compared with that in the normal control group. The upregulated expression of miRNA‑634 in an in vitro model of cerebral infarction increased cell apoptosis and the protein expression of capsase‑3/B‑cell lymphoma 2‑associated X protein (Bax) via inactivation of the phosphoinositide 3‑kinase (PI3K)/Akt pathway. The downregulation of miRNA‑634 enhanced cell growth and inhibited cell apoptosis in the in vitro model of cerebral infarction through induction of the PI3K/Akt pathway. Subsequently, a PI3K inhibitor was used to inhibit the expression of PI3K in the in vitro model of cerebral infarction via the downregulation of miRNA‑634, which showed that cell apoptosis and the protein expression of capsase‑3/Bax were also increased. A PI3K agonist reduced the effects of the upregulation of miRNA‑634 in the in vitro model of cerebral infarction. In conclusion, the data obtained demonstrated the possible future use of miRNA‑634 as a therapeutic target in cerebral infarction through the PI3K/Akt pathway.

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Understanding flow patterns and inflammatory status in intracranial aneurysms: Towards a personalized medicine

Cited by 16 publications

References 47 publications

Hemodynamic Differences Between Recurrent and Nonrecurrent Intracranial Aneurysms: Fluid Dynamics Simulations Based on MR Angiography

Hemodynamic Differences Between Recurrent and Nonrecurrent Intracranial Aneurysms: Fluid Dynamics Simulations Based on MR Angiography

A functional polymorphism in the promoter region of miR‐155 predicts the risk of intracranial hemorrhage caused by rupture intracranial aneurysm

MicroRNA‑634 alters nerve apoptosis via the PI3K/Akt pathway in cerebral infarction

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