2008
DOI: 10.1007/s11910-008-0057-3
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Understanding hippocampal sclerosis in the elderly: Epidemiology, characterization, and diagnostic issues

Abstract: Hippocampal sclerosis (HS) is a pathologic term used to describe severe loss of neurons and reactive gliosis without cystic cavitation in the CA1 sector of the hippocampus. In late life, HS is associated with hippocampal atrophy, severe amnesia, and slowly progressive dementia without clinical seizure activity. HS is difficult to distinguish clinically from Alzheimer's disease and is often diagnosed postmortem. In autopsy series, HS may be found without significant other pathology (2%-4% of cases), but it occu… Show more

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Cited by 98 publications
(107 citation statements)
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References 43 publications
(34 reference statements)
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“…In contrast, hippocampal sclerosis of aging (HS‐Aging) is considered as a distinct, dementia‐related pathology 18, 31, 35, 56, 58, neuropathologically characterized by severe neuron loss and gliosis in the CA1 area. The subiculum may be affected, but CA4, CA3 and are CA2 spared 16, 41, 43.…”
Section: Introductionmentioning
confidence: 99%
“…In contrast, hippocampal sclerosis of aging (HS‐Aging) is considered as a distinct, dementia‐related pathology 18, 31, 35, 56, 58, neuropathologically characterized by severe neuron loss and gliosis in the CA1 area. The subiculum may be affected, but CA4, CA3 and are CA2 spared 16, 41, 43.…”
Section: Introductionmentioning
confidence: 99%
“…1 ) [1] . HpScl is common in elderly subjects with dementia, either alone or accompanied by other pathologic processes [2] . It is most often associated with pathologic features of frontotemporal lobar degeneration (FTLD) [3,4] and can be detected in more than 75% of FTLD cases [5] .…”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, changes in hippocampal volume may be related to AD-type or vascular pathology [198] in such a way that the atrophy of hippocampus may occur in response to a degenerative or vascular process [199]. The different criteria used so far for mixed dementia around the world are detailed comparatively in Table 3 [24][25][26][200][201][202].…”
Section: The Classification By the Consortium To Establish A Registrymentioning
confidence: 99%