Understanding hypertriglyceridemia in women: clinical impact and management with prescription omega-3-acid ethyl esters

Dayspring, Thomas

doi:10.2147/ijwh.s16702

Cited by 19 publications

(13 citation statements)

References 67 publications

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“…Natural menopause is known to be associated with increased central adiposity [24]; further, in cases of similar mean BMI values for premenopausal and postmenopausal women, increased WC has been found to be significantly associated with postmenopausal status after adjusting for age [20]. A previous study reported that serum 25(OH)D levels were negatively associated with WC [34].…”

Section: Discussionmentioning

confidence: 92%

Association between Vitamin D Status and Risk of Metabolic Syndrome among Korean Postmenopausal Women

et al. 2014

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This study aimed to investigate the association between serum levels of 25-hydroxyvitamin D [25(OH)D] and metabolic syndrome along with its associated risk factors in Korean postmenopausal women. This study was performed using data from the KNHANES 2008–2010 study and included 4,364 postmenopausal Korean women. Clinical and other objective characteristics, seasonality, and presence of metabolic syndrome with its five components were evaluated and correlated with the serum levels of 25(OH)D. Although no statistically significant associations were observed between the levels of serum 25(OH)D and the prevalence of metabolic syndrome, the adjusted OR for elevated blood pressure, elevated triglycerides (TGs), and reduced high-density lipoprotein cholesterol (HDL-C) showed tendency to decrease sequentially as tertiles of serum 25(OH)D levels increased (p for trends = 0.066, 0.043, and 0.010, respectively). Women in the highest tertile of serum 25(OH)D showed a significant decrease in the prevalence of elevated blood pressure, elevated TGs, and reduced HDL-C as compared with those in the lowest tertile of serum 25(OH)D (p = 0.020, 0.014, and 0.002, respectively). Based on these results, we consider that adequate serum levels of 25(OH)D in Korean postmenopausal women may not entirely indicate a lower risk of developing metabolic syndrome. However, adequate serum levels of 25(OH)D are significantly associated with a decrease in elevated blood pressure, elevated TGs, and reduced HDL-C levels in postmenopausal women.

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Section: Discussionmentioning

confidence: 92%

Association between Vitamin D Status and Risk of Metabolic Syndrome among Korean Postmenopausal Women

et al. 2014

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“…While the benefits of fish oil in the diet are widely known and appreciated, including lowered coronary arteriosclerosis risk, a product (Lovaza®) has recently appeared on the market with the specific therapeutic goal of reducing serum triglycerides (Dayspring, 2011). This product is composed of the ethyl esters of various ω-3 fatty acids obtained from fish, mainly comprised of EPA (20:5n3) and DHA (22:6n3), administered as 400 mg/day.…”

Section: Some Marine Drug Discovery Success Storiesmentioning

confidence: 99%

Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology

Gerwick

Moore

2012

Chemistry & Biology

549

395

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Summary Marine life forms are an important source of structurally-diverse and biologically-active secondary metabolites, several of which have inspired the development of new classes of therapeutic agents. These success stories have had to overcome difficulties inherent to natural products-derived drugs, such as adequate sourcing of the agent and issues related to structural complexity. Nevertheless, several marine-derived agents are now approved, most as `first-in-class' drugs, with 5 of 7 appearing in the past few years. Additionally, there is a rich pipeline of clinical and pre-clinical marine compounds to suggest their continued application in human medicine. Understanding of how these agents are biosynthetically assembled has accelerated in recent years, especially through interdisciplinary approaches, and innovative manipulations and re-engineering of some of these gene clusters are yielding novel agents of enhanced pharmaceutical properties compared with the natural product.

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“…The reason for this gender difference might be related to the mechanism of hypertriglyceridemia in postmenopausal women, which induced small LDL particles. [18][19][20] There were age or gender-related differences in the ability to generate sdLDL-C from LDL-C. This ability in men was higher than that in women for all age groups or standardized groups, which is identical to the fact that atherosclerosis is more common in men than in women, considering sdLDL-C is a highly atherogenic factor.…”

Section: Discussionmentioning

confidence: 90%

Effects of Age, Gender, and Menopausal Status on Small Dense Low-Density Lipoprotein Cholesterol and Low-Density Lipoprotein Cholesterol Fractions; JMS-II Cohort Study

Izumida

Nakamura

Sato

et al. 2020

Preprint

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Background:Small dense low-density lipoprotein cholesterol (sdLDL-C) might be a better cardiovascular disease (CVD) indicator than low-density lipoprotein cholesterol (LDL-C); however, details regarding its epidemiology remain elusive. The present study aimed at evaluating the effect of age, gender, and menopausal status on sdLDL-C levels and sdLDL-C/LDL-C ratio in the Japanese population.Methods:We examined the baseline cross-sectional data from the Jichi Medical School-II Cohort Study, including 5,208 participants (2,397 men and 2,811 women). To assess age-related trends, the sdLDL-C and sdLDL-C/LDL-C ratios were plotted against gender. We evaluated the effect of age and menopausal status using multiple linear regression analysis.Results:We observed that in men, the sdLDL-C levels and sdLDL-C/LDL-C ratio increased during younger adulthood, peaked at 50–54 years, and then decreased. In women, we observed relatively regular increasing trends of sdLDL-C level and sdLDL-C/LDL-C ratio until approximately 65 years, followed by a downward or pleated trend. The crossover of sdLDL-C levels for the genders occurred at 70–74 years, but we could not observe any sdLDL-C/LDL-C ratio crossover. Standardized sdLDL-C levels and sdLDL-C/LDL-C ratio in 50-year old men, premenopausal women, and postmenopausal women were 26.6, 22.7, and 27.4 mg/dL and 0.24, 0.15, and 0.23, respectively. The differences between premenopausal and postmenopausal women were significant (P<0.001).Conclusions:sdLDL-C and sdLDL-C/LDL-C ratios show different distributions by age, gender, and menopausal status with trends different from other lipids. A subgroup-specific approach would be necessary to implement sdLDL-C for CVD prevention strategies, fully considering age-related trends, gender differences, and menopausal status.

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Understanding hypertriglyceridemia in women: clinical impact and management with prescription omega-3-acid ethyl esters

Cited by 19 publications

References 67 publications

Association between Vitamin D Status and Risk of Metabolic Syndrome among Korean Postmenopausal Women

Association between Vitamin D Status and Risk of Metabolic Syndrome among Korean Postmenopausal Women

Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology

Effects of Age, Gender, and Menopausal Status on Small Dense Low-Density Lipoprotein Cholesterol and Low-Density Lipoprotein Cholesterol Fractions; JMS-II Cohort Study

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