Understanding idiopathic intracranial hypertension: mechanisms, management, and future directions

Markey, Keira; Mollan, Susan P; Jensen, Rigmor Højland; Sinclair, Alexandra J

doi:10.1016/s1474-4422(15)00298-7

Cited by 412 publications

(478 citation statements)

References 117 publications

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“…1 The presentation is variable but typically includes chronic headaches and, in the majority, papilloedema that can result in visual decline. 2 IIH has a striking phenotype of young, obese women of childbearing age.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Fat Distribution in Idiopathic Intracranial Hypertension Using Dual-Energy X-ray Absorptiometry Scanning

Hornby

Botfield

O’Reilly

et al. 2017

Neuro-Ophthalmology

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Idiopathic intracranial hypertension (IIH) is strongly associated with obesity. We aimed to utilise dual-energy X-ray absorptiometry (DEXA) to characterise fat distribution, and to evaluate change in fat mass and distribution following weight loss. IIH patients (n = 24) had a similar fat distribution to body mass index (BMI)– and gender-matched obese controls (n = 47). In the IIH cohort, truncal fat mass correlated with lumbar puncture pressure. Weight loss in IIH patients resulted in a significant reduction in disease activity and fat mass, predominantly from the truncal region (−4.40 ± 1.6%; p = 0.008) compared with the limbs (+0.79 ± 6.5%; p = 0.71). These results indicate that, contrary to previous studies using waist-hip ratios, IIH adiposity is centripetal, similar to simple obesity. Future studies should establish the risk of the metabolic syndrome and the role of adipose tissue depot–specific function in IIH.

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Section: Introductionmentioning

confidence: 99%

Evaluating the Fat Distribution in Idiopathic Intracranial Hypertension Using Dual-Energy X-ray Absorptiometry Scanning

Hornby

Botfield

O’Reilly

et al. 2017

Neuro-Ophthalmology

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“…2 The condition has a predilection for obese women of childbearing age, 3 yet the reasons for this are not clear. 4 …”

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confidence: 99%

What Do Transgender Patients Teach Us About Idiopathic Intracranial Hypertension?

Hornby

Mollan

Mitchell

et al. 2017

Neuro-Ophthalmology

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Idiopathic intracranial hypertension (IIH), a condition of raised intracranial pressure, is characterised by headaches and visual disturbances. Its pathogenesis is currently unknown; however, dysregulation of androgens may be implicated. Here, the authors present a case of a 22-year-old patient undergoing female-to-male (FTM) gender reassignment who developed IIH shortly after commencing testosterone therapy. This interesting case presents the possibility of androgens having a pathogenic role in IIH.

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“…In idiopathic intracranial hypertension (IIH), there is an increase in intracranial pressure without a morphological intracranial pathology visible on imaging [40]. This must be differentiated from pseudotumor cerebri, which is often used synonymously [41] and refers to an increase in intracranial pressure with a definable cause (▶ Table 3) [40].…”

Section: Idiopathic Intracranial Hypertensionmentioning

confidence: 99%

“…This must be differentiated from pseudotumor cerebri, which is often used synonymously [41] and refers to an increase in intracranial pressure with a definable cause (▶ Table 3) [40]. IIH primarily affects overweight women of childbearing age.…”

Section: Idiopathic Intracranial Hypertensionmentioning

confidence: 99%

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Diagnosis and Differential Diagnosis of Hydrocephalus in Adults

Langner

Fleck

Baldauf

et al. 2017

Fortschr Röntgenstr

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ABSTR AC TPurpose Hydrocephalus is caused by an imbalance of production and absorption of cerebrospinal fluid (CSF) or obstruction of its pathways, resulting in ventricular dilatation and increased intracranial pressure. Imaging plays a crucial role in the diagnosis, differential diagnosis and planning of treatment.Methods This review article presents the different types of hydrocephalus und their typical imaging appearance, describes imaging techniques, and discusses differential diagnoses of the different forms of hydrocephalus. Results and Conclusion

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Understanding idiopathic intracranial hypertension: mechanisms, management, and future directions

Cited by 412 publications

References 117 publications

Evaluating the Fat Distribution in Idiopathic Intracranial Hypertension Using Dual-Energy X-ray Absorptiometry Scanning

Evaluating the Fat Distribution in Idiopathic Intracranial Hypertension Using Dual-Energy X-ray Absorptiometry Scanning

What Do Transgender Patients Teach Us About Idiopathic Intracranial Hypertension?

Diagnosis and Differential Diagnosis of Hydrocephalus in Adults

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