Understanding Immune Resistance to Infectious Bronchitis Using Major Histocompatibility Complex Chicken Lines

Silva, Ana Paula da; Hauck, Rüdiger; Zhou, Huaijun; Gallardo, Rodrigo A.

doi:10.1637/11666-050117-regr

Cited by 19 publications

(16 citation statements)

References 29 publications

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“…As with other species, inbred status and specific chicken lines have been shown to impact host susceptibility, immune response, and outcomes, and virus-host genetic interactions have been described. 100 , 101 , 102 Breeding experiments have suggested different inheritance patterns related to susceptibility and outcomes and have implicated both MHC and non-MHC loci. 63 , 103 Multiple GWASs investigating immune response to IBV have identified significantly associated polymorphisms in the breeds studied; 104 , 105 the implicated or nearest genes include AKT1 , AvBD12 , CEP170B , CRYL1 , CWF19L2 , DHRSX , FAM19A2 , GABRB3 , INTS9 , NMNAT3 , PINX1 , RAB39A , VRK1 , YEATS2, and SETBP1 (see Figure 2 , including related to genes identified through studies of other animals as described below).…”

Section: Introductionmentioning

confidence: 99%

The Role of Host Genetic Factors in Coronavirus Susceptibility: Review of Animal and Systematic Review of Human Literature

LoPresti

Beck

Duggal

et al. 2020

The American Journal of Human Genetics

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Summary The SARS-CoV-2 pandemic raises many scientific and clinical questions. These include how host genetic factors affect disease susceptibility and pathogenesis. New work is emerging related to SARS-CoV-2; previous work has been conducted on other coronaviruses that affect different species. We reviewed the literature on host genetic factors related to coronaviruses, systematically focusing on human studies. We identified 1,832 articles of potential relevance. Seventy-five involved human host genetic factors, 36 of which involved analysis of specific genes or loci; aside from one meta-analysis, all were candidate-driven studies, typically investigating small numbers of research subjects and loci. Three additional case reports were described. Multiple significant loci were identified, including 16 related to susceptibility (seven of which identified protective alleles) and 16 related to outcomes (three of which identified protective alleles). The types of cases and controls used varied considerably; four studies used traditional replication/validation cohorts. Among other studies, 30 involved both human and non-human host genetic factors related to coronavirus, 178 involved study of non-human (animal) host genetic factors related to coronavirus, and 984 involved study of non-genetic host factors related to coronavirus, including involving immunopathogenesis. Previous human studies have been limited by issues that may be less impactful now, including low numbers of eligible participants and limited availability of advanced genomic methods; however, these may raise additional considerations. We outline key genes and loci from animal and human host genetic studies that may bear investigation in the study of COVID-19. We also discuss how previous studies may direct current lines of inquiry.

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Section: Introductionmentioning

confidence: 99%

The Role of Host Genetic Factors in Coronavirus Susceptibility: Review of Animal and Systematic Review of Human Literature

LoPresti

Beck

Duggal

et al. 2020

The American Journal of Human Genetics

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“…As with other species, inbred status and specific chicken lines impact host susceptibility, immune response, and outcomes, and virus/host genetic interactions have been described. 43–47 Breeding experiments have suggested different inheritance patterns related to susceptibility and outcomes, and have implicated both MHC and non-MHC loci. 48,49 Multiple GWAS investigating the immune response to IBV have identified significantly-associated polymorphisms in the breeds studied; 50,51 the implicated or nearest genes include: AKT1, AvBD12, CEP170B, CRYL1, CWF19L2, DHRSX, FAM19A2, GABRB3, INTS9, NMNAT3, PINX1, RAB39A, VRK1, YEATS2; and SETBP1 : 50,51…”

Section: Resultsmentioning

confidence: 99%

The Role of Host Genetic Factors in Coronavirus Susceptibility: Review of Animal and Systematic Review of Human Literature

LoPresti

Beck

Duggal

et al. 2020

Preprint

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Background: The recent SARS-CoV-2 pandemic raises many scientific and clinical questions. One set of questions involves host genetic factors that may affect disease susceptibility and pathogenesis. New work is emerging related to SARS-CoV-2; previous work has been conducted on other coronaviruses that affect different species. Objectives: We aimed to review the literature on host genetic factors related to coronaviruses, with a systematic focus on human studies. Methods: We conducted a PubMed-based search and analysis for articles relevant to host genetic factors in coronavirus. We categorized articles, summarized themes related to animal studies, and extracted data from human studies for analyses. Results: We identified 1,187 articles of potential relevance. Forty-five studies were related to human host genetic factors related to coronavirus, of which 35 involved analysis of specific genes or loci; aside from one meta-analysis on respiratory infections, all were candidate-driven studies, typically investigating small number of research subjects and loci. Multiple significant loci were identified, including 16 related to susceptibility to coronavirus (of which 7 identified protective alleles), and 16 related to outcomes or clinical variables (of which 3 identified protective alleles). The types of cases and controls used varied considerably; four studies used traditional replication/validation cohorts. Of the other studies, 28 involved both human and non-human host genetic factors related to coronavirus, 174 involved study of non-human (animal) host genetic factors related to coronavirus, 584 involved study of non-genetic host factors related to coronavirus, including involving immunopathogenesis, 16 involved study of other pathogens (not coronavirus), 321 involved other studies of coronavirus, and 18 studies were assigned to the other categories and removed. Key findings: We have outlined key genes and loci from animal and human host genetic studies that may bear investigation in the nascent host genetic factor studies of COVID-19. Previous human studies to date have been limited by issues that may be less impactful on current endeavors, including relatively low numbers of eligible participants and limited availability of advanced genomic methods.

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“…We report the combined effects of vaccination to IBV and of different MHC genotypes of experimental laying hens on their caecal microbiota in a context of IBV infection. Experimental IBV challenge enabled us to fully follow the capacity of birds to decrease the viral load and thus their level of protection and recovery as IBV-speci c immunoglobulin level per se is not a good predictor of protective immunity (49,50). Once established the respective effects of the line and of the vaccination on the caecal microbiota, we investigated the associations between the caecal microbiota composition and immune phenotypes of the challenged animals.…”

Section: Discussionmentioning

confidence: 99%

Caecal Microbiota Composition of Experimental Laying Hens Differs According to Genetic Line and Vaccination to IBV

Borey

Bed'Hom

Bruneau

et al. 2021

Preprint

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BackgroundInteractions between the gut microbiota and the immune system may be involved in the vaccine response. In the present study, we studied the correlations between caecal microbiota composition and the immune response in six experimental laying hen lines harboring different haplotypes at the Major Histocompatibility complex (MHC), 7 weeks after their first vaccination against the infectious bronchitis virus (IBV). Two lines were previously considered as high responders (HR) to IBV vaccination and two other ones as low responders (LR). We explored to what extent the gut microbiota could be related to this variability through the characterization of caecal bacterial communities with a 16S rRNA gene amplicon sequencing approach, one week after an IBV infectious challenge. ResultsWe observed significant effects of both the vaccination and the genetic line on the microbiota, with lower bacterial richness in vaccinated chickens, especially in the Ruminococcaceae family. We also observed dissimilar caecal communities among the different MHC lines, and among the vaccinated and non-vaccinated animals. The effect of vaccination was similar in all the lines, with a reduced abundance of OTUs from the Ruminococcacea UCG-014 and Faecalibacterium genera, and an increased abundance of OTUs from the Eisenbergiella genus. The main association between the microbiota and the immune phenotypes implied TCRϒδ expression on TCRϒδ+ T cells, which especially shared negative associations with OTUs from the Escherichia-Shigella genus. Finally, opposing the HR and LR groups, we identified 3 OTUs more abundant in the HR group, from the Tyzzeralla family, the Angelakisella genus, and to a lower extent the Flavonifractor family. Conversely, an OTU from the CAG-352 genus was more abundant in the LR group. ConclusionsWe assessed that the caecal microbiota composition is associated with the IBV vaccine response in laying chickens, and that TCRϒδ expression on TCRϒδ+ T cells appears as one of the main components potentially involved in this interaction.

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Understanding Immune Resistance to Infectious Bronchitis Using Major Histocompatibility Complex Chicken Lines

Cited by 19 publications

References 29 publications

The Role of Host Genetic Factors in Coronavirus Susceptibility: Review of Animal and Systematic Review of Human Literature

The Role of Host Genetic Factors in Coronavirus Susceptibility: Review of Animal and Systematic Review of Human Literature

The Role of Host Genetic Factors in Coronavirus Susceptibility: Review of Animal and Systematic Review of Human Literature

Caecal Microbiota Composition of Experimental Laying Hens Differs According to Genetic Line and Vaccination to IBV

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