Understanding molecular mechanisms in peritoneal dissemination of colorectal cancer

Cuba, Erienne M. V. de; Kwakman, R.; Egmond, Marjolein van; Bosch, Linda J.W.; Bonjer, H. Jaap; Meijer, Gerrit A.; Velde, Elisabeth A. te

doi:10.1007/s00428-012-1287-y

Cited by 57 publications

(58 citation statements)

References 98 publications

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“…Liver metastases are caused by hematogenous spread, while peritoneal metastases require detachment of malignant cells, invasion of the peritoneal surface, and successful colonization. 13 Several studies have compared the biology of primary colon, liver, and peritoneal metastases. Varghese et al examined 14 liver tumors and 6 peritoneal tumors and found that metastases in these two sites clustered together.…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Colorectal Cancer in West African and North American Patients: Is the Cancer Biology Different?

Saluja

Alatise

Adisa

et al. 2014

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

A Comparison of Colorectal Cancer in West African and North American Patients: Is the Cancer Biology Different?

Saluja

Alatise

Adisa

et al. 2014

Journal of Surgical Research

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“…Colon cancer, a sort of malignant tumor in alimentary canal, has higher incidence and mortality. Hence, how to assess its therapeutic effect becomes an important problem in medical field (de Cuba et al, 2012;Benhaim et al, 2012;Yu, et al, 2012). In the study, three representative tumor markers TSGF, CEA and AFP are screened to explore their level variations before and after radical operation for colon cancer as well as the decreased levels at different clinical stagings and differentiation degrees, which are of great theoretical and clinical research value.…”

Section: Discussionmentioning

confidence: 99%

Expression and Significance of TSGF, CEA and AFP in Patients Before and after Radical Surgery for Colon Cancer

Hu¹,

Wang²,

Tao³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Objective: To explore the expression and significance of tumor specific growth factor (TSGF), carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP) in cancer tissue and serum of patients with colon cancer. Materials and Methods: Radical surgery for colon cancer was performed on 43 patients with laparoscopu under conditions of general anesthesia. The Elisa method was used to detect the levels of serum TSGF, CEA and AFP before and after radical operation, and cancer tissue underwent TSGF, CEA and AFP immunohistochemistry staining after laparoscopic surgery. The decreased conditions of serum TSGF, CEA and AFP in patients with colon cancer at different levels of differentiation and clinical stagings were analyzed, and the relationships of expression rates between histological types, colon cancer morphology, lymph node metastasis and TSGF, CEA as well as AFP in cancer tissue were assessed. Results: Compared with before radical surgery, the levels of serum TSGF, CEA and AFP decreased notably in patients after operations (p<0.01). The decreased degree of TSGF and CEA was the largest in patients with poorly differentiated cancer tissue (p<0.01), while that of AFP was noted in patients with moderately differentiated cancer tissue (p<0.01). The decreased degree of TSGF and AFP was the largest in patients at phase Dukes A (p<0.01), while that of CEA in patients at phase Dukes C (p<0.01). There were no significant differences among the positive expression rates of TSGF, CEA and AFP with different histological types and colon cancer morphologies (p>0.05). The positive expression rates of TSGF and CEA in patients with lymph node metastasis were significantly higher than those without lymph node metastasis (p<0.01). Conclusions: TSGF, CEA and AFP can be used to evaluate the effect of radical operation for colon cancer, and the changed levels of different markers are associated with tumor differentiation, clinical stating and presence or absence of lymph node metastasis.

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“…The development of PC involves a complex sequence of continuous and interdependent steps [8][9][10], known as the "peritoneal metastatic cascade" [6]; including cell shedding and transport, adhesion to the mesothelial layer, invasion and proliferation into the submesothelial stroma, and potential access to the systemic circulation [9,10].…”

Section: Molecular Biology Of Colorectal Cancer Peritoneal Carcinomatmentioning

confidence: 99%

“…In recent years, with the introduction of regional therapy and new chemotherapeutic and biologic agents, the outcomes for these patients has improved [21] but careful patient selection is needed, because of its significant but acceptable morbidity/mortality and cost [10,22]. Results of large multicentre studies have identified several prognostic factors that can be used to improve selection of CRC with carcinomatosis who will benefit from cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC).…”

Section: Management Of Crc Peritoneal Carcinomatosismentioning

confidence: 99%

Update on Colorectal Carcinomatosis—From Molecular Biology to Diagnosis and Management

Martins¹,

Filho²

2013

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After liver metastases, Peritoneal Carcinomatosis (PC) is the second most frequent cause of death in patients with Colorectal Cancer (CRC), although the precise incidence of Colorectal Cancer Peritoneal Carcinomatosis is not known, as the majority of the diagnostic studies cannot detect the disease in its initial stages, nowadays, the diagnosis of peritoneal carcinomatosis remains a challenge. The molecular biology of PC is only just beginning to be understood, future knowledge will permit not only identify novel strategies for PC prevention, but also contribute to therapeutic advances, through the development of molecular targeted therapies. The authors performed a literature revision about the Molecular Biology, Diagnosis and Management of Colorectal Cancer Peritoneal carcinomatosis.

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Understanding molecular mechanisms in peritoneal dissemination of colorectal cancer

Cited by 57 publications

References 98 publications

A Comparison of Colorectal Cancer in West African and North American Patients: Is the Cancer Biology Different?

A Comparison of Colorectal Cancer in West African and North American Patients: Is the Cancer Biology Different?

Expression and Significance of TSGF, CEA and AFP in Patients Before and after Radical Surgery for Colon Cancer

Update on Colorectal Carcinomatosis—From Molecular Biology to Diagnosis and Management

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