Understanding Motor Abnormalities in Psychiatric Disorders as Altered Sensorimotor Processing

Rungratsameetaweemana, Nuttida

doi:10.1016/j.bpsgos.2021.06.006

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2021

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“…The underlying cause of Tourette syndrome remains elusive, despite significant research and several important theoretical results [ 18 , 19 , 20 , 21 ]. Similarly, the mechanism of efficacy of DBS is poorly understood [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Transient Complete Resolution of Tourette Syndrome Symptoms Following Personalized Depth Electrode Placement

et al. 2021

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Treatment refractory Tourette syndrome has been shown to be improved with deep brain stimulation, but with multiple possible stimulation locations and variable and incomplete benefit. This study presents a single case of complete amelioration of motor and verbal tics in a patient with Tourette syndrome during placement of 12 stereo-EEG electrodes to identify optimal targets for permanent stimulating electrodes. Subsequently, substantial improvement in motor and verbal tic frequency occurred with placement and programming of permanent electrodes in bilateral globus pallidus internus and nucleus accumbens, but without the complete resolution seen during depth electrode placement. We suggest that simultaneous stimulation at multiple patient-specific targets could provide effective control of Tourette symptomatology, but further study will be needed.

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