Understanding of Dose-Response of Metformin by Using Continuous Glucose Monitoring

Does Metformin Assist New Anti-Diabetic Drugs to Succeed?

“…Although various mechanisms have been suggested as metformin-mediated glucose-lowering, it remains unknown which of these mechanisms plays a crucial role at various daily doses of metformin. Our previous [12] and present study using CGM demonstrated that metformin improved GV in a dose-dependent manner (Fig. 2).…”