Understanding of Quorum – Sensing: A Possible Solution for Drug Resistance in Bacteria

Bose, Seema; Ghosh, Atindra Krishna

doi:10.20546/ijcmas.2016.502.061

Cited by 3 publications

(2 citation statements)

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“…The results indicated that (49.6 %) out of 121 isolates were positive for Iasl gene (Table 3). Bacteria use QS to regulate genes expression, facilitate pathogenic invasion and spread virulence factors 49 . The QS controls local bacteria population and cell density, which make the bacteria behave as a collaborative community such as multicellular organism 50 .…”

Section: -Quorum Sensing Detection In Acinetobactermentioning

confidence: 99%

Prevalence of Genes Involved in Colistin Resistance inAcinetobacter baumannii:First Report from Iraq

Al-Kadmy

Ibrahim

Al-Saryi

et al. 2020

Microbial Drug Resistance

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Background and aim: Colistin is increasingly being used as a 'last-line' therapy to treat infections caused by multi-drug resistant Acinetobacter baumannii (A. baumannii) isolates, when essentially no other options are available in these days. The aim of this study was to detect genes associated with Colistin resistance in A. baumannii. Methods: 121 isolates of A. baumannii were collected from clinical and environmental samples during 2016 to 2018 in Baghdad. Isolates were diagnosed as A. baumannii by using morphological tests, Vitek-2 system, 16SrRNA PCR amplification and sequencing. Antibiotic susceptibility test was carried out using disc diffusion method. Phenotypic detection of colistin resistance was performed by CHROMagar TM COL-APSE medium and broth microdilution method for the determination of the minimal inhibitory concentration (MIC). Molecular detection of genes responsible for colistin resistance in A. baumannii was performed by PCR. Results: 92 (76%) out of 121 A. baumannii isolates were colistin resistant. 26 (21.5%) out of 121 isolates showed positive growth on CHROM agar Acinetobacter base for MDR. PCR detected mcr-1, mcr-2 and mcr-3 genes in 89 (73.5%), 78 (64.5%) and 82 (67.8%) in the A. baumannii isolates respectively. 78 (64.5%) out of 121 isolates harbored the integron intI2 gene and 81 (66.9%) contained intI3 gene. Moreover, 60 (49.6 %) out of 121 isolates were positive for the quorum sensing Iasl gene Conclusion: The presence of a large percentage of colistin resistant A. baumannii strains in Baghdad may be due to the presence of mobile genetic elements and it is urgent to avoid unnecessary clinical use of colistin.

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Section: -Quorum Sensing Detection In Acinetobactermentioning

confidence: 99%

Prevalence of Genes Involved in Colistin Resistance inAcinetobacter baumannii:First Report from Iraq

Al-Kadmy

Ibrahim

Al-Saryi

et al. 2020

Microbial Drug Resistance

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“…They produce small easily diffusible hormone-like molecules known as autoinducers, which are used to observe their population density and to adapt in an ever-changing environment. 29 Like other Gram-negative rods, Acinetobacter yields acylhomoserine lactones as signaling molecules for interspecies and intraspecies communication. It also produces less-studied signaling molecules such as diketopiperazines, 2-heptyl-3-hydroxy-4-quinolone, and retention factor 1.…”

Section: Introductionmentioning

confidence: 99%

Insight into <em>Acinetobacter baumannii</em>: pathogenesis, global resistance, mechanisms of resistance, treatment options, and alternative modalities

Asif

Alvi

Rehman

2018

IDR

251

224

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Acinetobacter baumannii, once considered a low-category pathogen, has emerged as an obstinate infectious agent. The scientific community is paying more attention to this pathogen due to its stubbornness to last resort antimicrobials, including carbapenems, colistin, and tigecycline, its high prevalence of infections in the hospital setting, and significantly increased rate of community-acquired infections by this organism over the past decade. It has given the fear of pre-antibiotic era to the world. To further enhance our understanding about this pathogen, in this review, we discuss its taxonomy, pathogenesis, current treatment options, global resistance rates, mechanisms of its resistance against various groups of antimicrobials, and future therapeutics.

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Synthesis, biological evaluations and computational studies of N-(3-(-2-(7-Chloroquinolin-2-yl)vinyl) benzylidene)anilines as fungal biofilm inhibitors

Khan¹,

Kaduskar²,

Patil

et al. 2019

Bioorganic & Medicinal Chemistry Letters

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Understanding of Quorum – Sensing: A Possible Solution for Drug Resistance in Bacteria

Cited by 3 publications

References 0 publications

Prevalence of Genes Involved in Colistin Resistance inAcinetobacter baumannii:First Report from Iraq

Prevalence of Genes Involved in Colistin Resistance inAcinetobacter baumannii:First Report from Iraq

Insight into <em>Acinetobacter baumannii</em>: pathogenesis, global resistance, mechanisms of resistance, treatment options, and alternative modalities

Synthesis, biological evaluations and computational studies of N-(3-(-2-(7-Chloroquinolin-2-yl)vinyl) benzylidene)anilines as fungal biofilm inhibitors

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