2013
DOI: 10.1016/j.clon.2013.06.012
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Understanding Radiation-induced Cardiovascular Damage and Strategies for Intervention

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Cited by 123 publications
(114 citation statements)
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“…A postulated mechanism suggests an inflammatory response to cellular damage from radiation exposure, which could potentially have implications for induction of other types of disease. An argument against this is that while acute doses (above 1 Gy) are considered to have an inflammatory effect, lower doses (below 0.5 Gy) have been recognized as having potentially anti-inflammatory properties that could possibly slow the progression of circulatory diseases (49)(50). A recent ICRP report classified circulatory diseases as a tissue reaction effect with a threshold for the effect of 0.5 Gy (51).…”
Section: Discussionmentioning
confidence: 99%
“…A postulated mechanism suggests an inflammatory response to cellular damage from radiation exposure, which could potentially have implications for induction of other types of disease. An argument against this is that while acute doses (above 1 Gy) are considered to have an inflammatory effect, lower doses (below 0.5 Gy) have been recognized as having potentially anti-inflammatory properties that could possibly slow the progression of circulatory diseases (49)(50). A recent ICRP report classified circulatory diseases as a tissue reaction effect with a threshold for the effect of 0.5 Gy (51).…”
Section: Discussionmentioning
confidence: 99%
“…Regarding cytokines and growth factors, an important role in this process is played by IL-1β and transformation growth factor β (TGF-β), which helps fibroblasts become fibrocytes (2,5). Radiotherapy can impair telomeres, producing senescence to the cells (4). Changes that can appear in an irradiated artery include intimal proliferation and thickening, smooth muscle cell hypertrophy and collagen deposition, disruption of elastic lamina, fibrosis, and obliteration of the vasa vasorum (6).…”
Section: Discussion Discussionmentioning
confidence: 99%
“…It seems that the small arteries are more radiosensitive than the large arteries; at this level there is evidence of inflammation that leads to endothelial dysfunction and then to a prothrombotic and antifibrinolytic response (1,2). In addition, oxidative stress resulted from radiolysis of water contributes to oxidation of low-density lipo-Intermittent claudication after radiotherapy for testicular malignancy proteins, recruiting leukocytes that will become lipidladen foam cells and inducing expression of inflammatory adhesion molecules (2,4). Regarding cytokines and growth factors, an important role in this process is played by IL-1β and transformation growth factor β (TGF-β), which helps fibroblasts become fibrocytes (2,5).…”
Section: Discussion Discussionmentioning
confidence: 99%
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“…In published epidemiological studies, the risk of cardiovascular disease (CVD) has been reported after exposure to ionizing radiation from radiotherapy (1-6), occupational and environmental settings (4,(6)(7)(8)(9)(10)(11)(12)(13)(14) and atomic bombs (15). While a published finding from the Life Span Study (LSS) of atomic bomb survivors indicated that mortality from CVD increased even six decades after whole-body irradiation (0.5-1.0 Gy) (15), several issues have yet to be elucidated.…”
Section: Introductionmentioning
confidence: 99%