Understanding Rift Valley fever: Contributions of animal models to disease characterization and control

Lorenzo, Gema; López-Gil, Elena; Warimwe, George M.; Brun, Alejandro

doi:10.1016/j.molimm.2015.02.001

Cited by 24 publications

(31 citation statements)

References 114 publications

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“…Malignancies are the second most common cause of death after cardiovascular disease in both genders in patients with IBD 128 . IBD has etiological links to CRC at multiple levels and autophagy plays a crucial protective role 129 .…”

Section: General Aspects Of the Unfolded Protein Responsementioning

confidence: 99%

New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets

et al. 2017

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Colorectal cancer (CRC), despite numerous therapeutic and screening attempts, still remains a major life-threatening malignancy. CRC etiology entails both genetic and environmental factors. Macroautophagy/autophagy and the unfolded protein response (UPR) are fundamental mechanisms involved in the regulation of cellular responses to environmental and genetic stresses. Both pathways are interconnected and regulate cellular responses to apoptotic stimuli. In this review, we address the epidemiology and risk factors of CRC, including genetic mutations leading to the occurrence of the disease. Next, we discuss mutations of genes related to autophagy and the UPR in CRC. Then, we discuss how autophagy and the UPR are involved in the regulation of CRC and how they associate with obesity and inflammatory responses in CRC. Finally, we provide perspectives for the modulation of autophagy and the UPR as new therapeutic options for CRC treatment.

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Section: General Aspects Of the Unfolded Protein Responsementioning

confidence: 99%

New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets

et al. 2017

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“…Nipah virus, identified in 1998, is emerging zoonosis that affects both animals and humans [13,[21][22][23][24]. Rift Valley fever is a viral zoonosis that was first identified among sheep on a farm in the Rift Valley of Kenya [25][26][27][28][29]. The WHO committee listed another three pathogens/infectious diseases and considered them as serious and require an action as soon as possible.…”

Section: Introductionmentioning

confidence: 99%

“…Literature review using Pubmed, Google Scholar and Scopus showed that bibliometric studies on SARS or Ebola or Nipah virus have been carried out, but as a single disease and not as a group of diseases with potential future severe epidemics [25][26][27][28][29]. The collective analysis of literature on top eight pathogens will give a more comprehensive view on these infectious diseases and will help identify which one needs to be given top priority for funding and research.…”

Section: Introductionmentioning

confidence: 99%

Global research trends of World Health Organization’s top eight emerging pathogens

2017

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BackgroundOn December 8th, 2015, World Health Organization published a priority list of eight pathogens expected to cause severe outbreaks in the near future. To better understand global research trends and characteristics of publications on these emerging pathogens, we carried out this bibliometric study hoping to contribute to global awareness and preparedness toward this topic.MethodScopus database was searched for the following pathogens/infectious diseases: Ebola, Marburg, Lassa, Rift valley, Crimean-Congo, Nipah, Middle Eastern Respiratory Syndrome (MERS), and Severe Respiratory Acute Syndrome (SARS). Retrieved articles were analyzed to obtain standard bibliometric indicators.ResultsA total of 8619 journal articles were retrieved. Authors from 154 different countries contributed to publishing these articles. Two peaks of publications, an early one for SARS and a late one for Ebola, were observed. Retrieved articles received a total of 221,606 citations with a mean ± standard deviation of 25.7 ± 65.4 citations per article and an h-index of 173. International collaboration was as high as 86.9%. The Centers for Disease Control and Prevention had the highest share (344; 5.0%) followed by the University of Hong Kong with 305 (4.5%). The top leading journal was Journal of Virology with 572 (6.6%) articles while Feldmann, Heinz R. was the most productive researcher with 197 (2.3%) articles. China ranked first on SARS, Turkey ranked first on Crimean-Congo fever, while the United States of America ranked first on the remaining six diseases. Of retrieved articles, 472 (5.5%) were on vaccine – related research with Ebola vaccine being most studied.ConclusionNumber of publications on studied pathogens showed sudden dramatic rise in the past two decades representing severe global outbreaks. Contribution of a large number of different countries and the relatively high h-index are indicative of how international collaboration can create common health agenda among distant different countries.

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“…In a minority of infected humans, the disease progresses from a self-limiting febrile illness to severe hepatitis with hemorrhagic manifestations, encephalitis, and ocular lesions 2 , 3 . The RVFV infection in laboratory rodents mimics many aspects of the pathology in humans 4 , 5 . In particular, infection of BALB/c mice recapitulates the hepatitis and encephalitis observed in human disease 6 .…”

Section: Introductionmentioning

confidence: 99%

Innate Immune Basis for Rift Valley Fever Susceptibility in Mouse Models

Lathan

Simon-Chazottes

Jouvion

et al. 2017

Sci Rep

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Rift Valley fever virus (RVFV) leads to varied clinical manifestations in animals and in humans that range from moderate fever to fatal illness, suggesting that host immune responses are important determinants of the disease severity. We investigated the immune basis for the extreme susceptibility of MBT/Pas mice that die with mild to acute hepatitis by day 3 post-infection compared to more resistant BALB/cByJ mice that survive up to a week longer. Lower levels of neutrophils observed in the bone marrow and blood of infected MBT/Pas mice are unlikely to be causative of increased RVFV susceptibility as constitutive neutropenia in specific mutant mice did not change survival outcome. However, whereas MBT/Pas mice mounted an earlier inflammatory response accompanied by higher amounts of interferon (IFN)-α in the serum compared to BALB/cByJ mice, they failed to prevent high viral antigen load. Several immunological alterations were uncovered in infected MBT/Pas mice compared to BALB/cByJ mice, including low levels of leukocytes that expressed type I IFN receptor subunit 1 (IFNAR1) in the blood, spleen and liver, delayed leukocyte activation and decreased percentage of IFN-γ-producing leukocytes in the blood. These observations are consistent with the complex mode of inheritance of RVFV susceptibility in genetic studies.

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Understanding Rift Valley fever: Contributions of animal models to disease characterization and control

Cited by 24 publications

References 114 publications

New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets

New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets

Global research trends of World Health Organization’s top eight emerging pathogens

Innate Immune Basis for Rift Valley Fever Susceptibility in Mouse Models

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