Understanding the Associations across Fibromyalgia-Related Fatigue, Depression, Anxiety, Self-Esteem Satisfaction with Life and Physical Activity in Portuguese and Brazilian Patients: A Structural Equation Modeling Analysis

Alvarez, Marcos C.; Albuquerque, Maria Luiza L.; Neiva, Henrique P.; Cid, Luís; Teixeira, Diogo; Matos, Rui; Antunes, Raúl; Lúcio, Liane; Sant'Ana, Leandro de Oliveira; Monteiro, Diogo

doi:10.3390/medicina58081097

Cited by 3 publications

(1 citation statement)

References 90 publications

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“…Fibromyalgia (FM) exists in 2-8% of the population, and is characterized by extensive pain, which is often accompanied by fatigue, memory problems, and sleep disorders (1,2). Although FM has been excluded from the diagnosis of neuropathic pain since the revision of the International Association for the Study of Pain (IASP) definition of neuropathic pain in 2011, recent studies have found that about 50% of FM patients have neuropathic changes of small and/or large fibers (3,4).…”

Section: Introductionmentioning

confidence: 99%

Methylation factors as biomarkers of fibromyalgia

Huang¹,

Zhang²,

Wei³

et al. 2023

Ann Transl Med

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Background: Fibromyalgia (FM) is a common and intractable chronic musculoskeletal pain syndrome, but its exact underlying mechanisms are unknown. This study sought to identify biomarkers of FM and the underlying molecular mechanisms of the disease.Methods: FM-related gene expression profiles (GSE67311) and methylation profiles (GSE85506) were obtained from the Gene Expression Omnibus database, and a differential expression analysis was performed to identify the methylation factors. Subsequently, an enrichment analysis and gene set enrichment analysis (GSEA) were conducted to examine the methylation factors. In addition, the transcriptional regulators of the methylation factors were predicted, and key methylation factors were identified by a receiver operating characteristic curve analysis and nomogram models. Finally, the relationship between FM and cell death (pyroptosis, necroptosis, and cuproptosis) was assessed by a GSEA and gene set variation analysis.Results: A total of 455 methylation factors were identified. The enrichment analysis and GSEA results showed that methylation factors were clearly involved in the biological functions and signaling pathways related to neural, immune inflammation, and pain responses. The transcriptional regulator specificity protein 1 (SP1) may have a broad regulatory role. Finally, seven key methylation factors were identified, of which amino beta (A4) precursor protein binding family B member 2 (APBB2), A-kinase anchor protein 12 (AKAP12), and cluster of differentiation 38 (CD38) had strong clinical diagnostic power. In addition, AKAP12 and CD38 were significantly and negatively associated with sepsis, necrotizing sepsis, and cupular sepsis.Conclusions: Our study suggests that FM is associated with deoxyribonucleic acid methylation. The methylation factors APBB2, AKAP12, and CD38 may be potential biomarkers and should be further examined to provide a new biological framework of the possible disease mechanisms underlying FM.

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Section: Introductionmentioning

confidence: 99%

Methylation factors as biomarkers of fibromyalgia

Huang¹,

Zhang²,

Wei³

et al. 2023

Ann Transl Med

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Mental Health in Fibromyalgia

Van Overmeire,

Vesentini,

Muysewinkel

et al. 2024

Handbook of the Behavior and Psychology of Disease

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Correlação Entre Fibromialgia E Ansiedade: Revisão Sistemática Da Literatura

Pellin,

Back,

Santiago

et al. 2024

Rev. Contemp.

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Além da catastrofização da dor, outras alterações na saúde mental podem agravar a sintomatologia da Fibromialgia, como, por exemplo, Ansiedade e Depressão. Em vista disso, objetivou-se recorrer à revisão de literatura com o objetivo de correlacionar o transtorno de Ansiedade e Fibromialgia e explorar os aspectos subjacentes que ambos os agravos parecem compartilhar. Trata-se de uma revisão sistemática da literatura realizada nas bases de dados LILACS, MEDLINE e SciELO no período de 2017-2023. Foram selecionados 19 estudos, prevalentemente transversais, cujos resultados corroboraram que pacientes com Fibromialgia apresentam uma prevalência significativamente maior de Ansiedade quando comparados aos controles saudáveis, que varia entre 28,75% a 87,50%. As evidências mostram que a dor crônica e a ansiedade se influenciam mutuamente. Foi comprovado que a ansiedade está associada a uma maior gravidade da dor e, por sua vez, níveis mais altos de dor aumenta ou induz níveis mais elevados de Ansiedade, denotando a relação bidirecional. Sugere-se que tais interações correlacionam-se ao funcionamento inadequado do sistema nervoso central devido à Fibromialgia. Além disso, descreve-se que as áreas cerebrais e as vias de neurotransmissores envolvidas na modulação da dor e na ansiedade se sobrepõem.

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Understanding the Associations across Fibromyalgia-Related Fatigue, Depression, Anxiety, Self-Esteem Satisfaction with Life and Physical Activity in Portuguese and Brazilian Patients: A Structural Equation Modeling Analysis

Cited by 3 publications

References 90 publications

Methylation factors as biomarkers of fibromyalgia

Methylation factors as biomarkers of fibromyalgia

Mental Health in Fibromyalgia

Correlação Entre Fibromialgia E Ansiedade: Revisão Sistemática Da Literatura

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