2024
DOI: 10.1017/erm.2024.23
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Understanding the autophagic functions in cancer stem cell maintenance and therapy resistance

Niharika,
Minal Garg

Abstract: Complex tumour ecosystem comprising tumour cells and its associated tumour microenvironment (TME) constantly influence the tumoural behaviour and ultimately impact therapy failure, disease progression, recurrence and poor overall survival of patients. Crosstalk between tumour cells and TME amplifies the complexity by creating metabolic changes such as hypoxic environment and nutrient fluctuations. These changes in TME initiate stem cell-like programmes in cancer cells, contribute to tumoural heterogeneity and … Show more

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