Understanding the cardiovascular risk with non-insulin antidiabetic drugs

Athyros, Vasilios G.; Imprialos, Κonstantinos; Stavropoulos, Konstantinos; Sahinidis, Alexandros G.; Doumas, Michael

doi:10.1080/14740338.2019.1586881

Cited by 9 publications

(4 citation statements)

References 106 publications

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“…Furthermore, SGLT2 inhibition reduces blood pressure, weight and has renal and cardiac benefits in individuals with preserved renal function 25 . Athyros et al 2 in his study reported that GLP-1 analogue, SGLT-2i, and metformin as better than other classes of antidiabetic drugs. In addition these also possess some cardiovascular benefits.…”

Section: Current Treatments Of Diabetes Mellitusmentioning

confidence: 95%

“…Diabetes mellitus is one of the major challenges across the globe, resulting in great financial and medical burden to the patients 1 . As per WHO, the worldwide prevalence of diabetes was recorded as 8.8% in 2017 whereas, 1.6 million deaths occurred owing to diabetes in 2016 2,3 . According to International Diabetes Federation (IDF), the diabetic population of the globe will reach to 629 million by 2045, which was recorded as 425 million in 2017 4 .…”

Section: Introductionmentioning

confidence: 99%

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Review on Plants for Management of Diabetes in India: An Ethno- Botanical and Pharmacological Perspective

Dixit¹,

Tiwari²

2020

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The diagnosis of early diabetes includes Glycosylated Haemoglobin (HbA1C), Glucose Tolerance Test (GTT), Fasting Plasma Glucose (FPG), Postprandial Plasma Glucose (PPG) test 16 . GTT helps to diagnose gestational diabetes, pre-diabetes, insulin resistance or reactive hypoglycemia. FPG & PPG level reflect the state of recent glycemia, whereas HbA1c level reflects chronic glycaemia. As per American Diabetes Association (ADA), HbA1c should be less than 7% ABSTRACT Background: Diabetes mellitus is a prevalent chronic disease, which is recognized as a common threat to health in the last decade, especially in Asia. It is a lifestyle disease which may cause a number of complications in the body of humans like cardiac failure and dysfunctioning of urinary tract. Materials and Methods: The data is obtained from various search tools and electronic databases like, scientific literature, Google scholar, Google, Pubmed, Web of science and Scopus. Results: Major therapy for diabetes is insulin, oralantidiabetic drugs, and herbal treatment. However, insulin and oral anti-diabetic drugs come with a number of side effects and cannot be afforded by people with below poverty line. The herbal medicines have performed a satisfactory clinical practice for the management of diabetes mellitus. Moreover, pharmacological & phytochemical screening of medicinal plants has also witnessed the hypoglycaemic effects of these plants in treating diabetes mellitus. Majority of the modern drugs like metformin, atropine, digitalis, etc. are also originated from plants. Conclusion: The current paper presents a review of medicinal plants used for diabetes management in India. The therapeutic potential, ethnobotanical use, and their pharmacological evaluations are highlighted for harnessing the anti-diabetic potential of these plants by the Indian healthcare system.

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Section: Current Treatments Of Diabetes Mellitusmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Review on Plants for Management of Diabetes in India: An Ethno- Botanical and Pharmacological Perspective

Dixit¹,

Tiwari²

2020

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“…[ 124–126 ] The latest studies of non‐insulin hypoglycemic drugs that highlight the opportunities and the limitations of using these compounds are well described elsewhere. [ 127–130 ]…”

Section: Implantable Drug Delivery Systemsmentioning

confidence: 99%

Wearable Glucose Monitoring and Implantable Drug Delivery Systems for Diabetes Management

Zhang

Lim

et al. 2021

Adv Healthcare Materials

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The global cost of diabetes care exceeds $1 trillion each year with more than $327 billion being spent in the United States alone. Despite some of the advances in diabetes care including continuous glucose monitoring systems and insulin pumps, the technology associated with managing diabetes has largely remained unchanged over the past several decades. With the rise of wearable electronics and novel functional materials, the field is well‐poised for the next generation of closed‐loop diabetes care. Wearable glucose sensors implanted within diverse platforms including skin or on‐tooth tattoos, skin‐mounted patches, eyeglasses, contact lenses, fabrics, mouthguards, and pacifiers have enabled noninvasive, unobtrusive, and real‐time analysis of glucose excursions in ambulatory care settings. These wearable glucose sensors can be integrated with implantable drug delivery systems, including an insulin pump, glucose responsive insulin release implant, and islets transplantation, to form self‐regulating closed‐loop systems. This review article encompasses the emerging trends and latest innovations of wearable glucose monitoring and implantable insulin delivery technologies for diabetes management with a focus on their advanced materials and construction. Perspectives on the current unmet challenges of these strategies are also discussed to motivate future technological development toward improved patient care in diabetes management.

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“…Além das complicações provenientes da própria doença, existem complicações relativas ao tratamento da insulinoterapia, por exemplo, hipoglicemia, Lipodistrofia, alergia local ou sistêmica e infecções nos locais de aplicação (BISSON, 2016). Entre os efeitos adversos ocasionados pelos antidiabéticos orais temos, por exemplo, hipoglicemia, aumento de peso e de apetite (uso limitante em pacientes obesos) pelas sulfoniureias, efeitos gastrointestinais e acidose lática ocasionada por biguanidas, retenção hídrica, ganho de peso e perda de densidade mineral óssea ocasionado pelas tiazolinedionas, entre outros (ATHYROS et al, 2019).O sucesso do tratamento do diabetes com o objetivo de manter os níveis de glicose de modo basal é extremamente importante para a manutenção da integridade física e psíquica de tais indivíduos portadores da doença.…”

Section: Introductionunclassified

Impacto da atenção farmacêutica no manejo de pacientes diabéticos

Moreira,

Santos

2020

Revista Científica Multidisciplinar Núcleo do Conhecimento

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O diabetes mellitus é um grupo de doenças metabólicas crônicas, caracterizado pelo aumento da glicemia dos portadores, sendo uma importante causa de mortalidade e morbidade, podendo, também, ter repercussões econômicas e sociais. Sabendo que a prática da atenção farmacêutica tem se mostrado muito importante na adesão e acompanhamento, proporcionando o uso seguro e racional de medicamentos, o objetivo deste trabalho foi realizar uma revisão de literatura sobre os estudos que impactam a atenção farmacêutica no manejo de pacientes diabéticos. Todos os estudos apontaram resultados positivos acerca da atenção farmacêutica à esse grupo de pacientes, com melhoras clínicas (redução da glicemia, HbA1c, pressão arterial, perfil lipídico), psicossociais e econômicas. Notando-se melhoras significativas na adesão ao tratamento antidiabético, a pesquisa visa cooperar para com a melhora dos resultados clínicos de pacientes desse grupo.

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Understanding the cardiovascular risk with non-insulin antidiabetic drugs

Cited by 9 publications

References 106 publications

Review on Plants for Management of Diabetes in India: An Ethno- Botanical and Pharmacological Perspective

Review on Plants for Management of Diabetes in India: An Ethno- Botanical and Pharmacological Perspective

Wearable Glucose Monitoring and Implantable Drug Delivery Systems for Diabetes Management

Impacto da atenção farmacêutica no manejo de pacientes diabéticos

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