Understanding the Complexities of Cirrhosis

Muir, Andrew J.

doi:10.1016/j.clinthera.2015.05.507

Cited by 49 publications

(44 citation statements)

References 107 publications

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“…These complications include HCC, portal hypertension, esophageal varices, ascites, jaundice and hepatic encephalopathy. It can be discovered clinically through hepatomegaly, palpable left liver lobe and the enlarged spleen [30][31][32][33]. HCC prevalence was found to be dominated by males within all etiologies, with an average age of 50 years.…”

Section: Clinical Presentation Of Compensated Liver Cirrhosis and Hccmentioning

confidence: 99%

Surgical Resection of Hepatocellular Carcinoma in Compensated Cirrhotic Liver: The Benefits and Selection Criteria

Doush

Elzein

2019

SJMS

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Section: Clinical Presentation Of Compensated Liver Cirrhosis and Hccmentioning

confidence: 99%

Surgical Resection of Hepatocellular Carcinoma in Compensated Cirrhotic Liver: The Benefits and Selection Criteria

Doush

Elzein

2019

SJMS

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“…2 Liver cirrhosis, decompensated chronic liver disease, hepatocellular carcinoma, and death due to liver failure is the known grave complications of HBV. 4,5 An estimated 350 million persons worldwide are chronically infected with HBV. HBV carriers are also at an increased risk of developing the decompensated liver disease, cirrhosis, and hepatoma.…”

Section: Introductionmentioning

confidence: 99%

HBV and HDV Seroprevalence among Healthy People Admitted for Hepatitis B Vaccination

Rahman

Amir

Siddiqui

et al. 2019

Turkish Journal of Family Medicine and Primary Care

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Background: An estimated 350 million persons worldwide are chronically infected with Hepatitis B virus (HBV). These are at increased risk of developing liver cirrhosis and hepatocellular carcinoma. The aim of the study was to determine the prevalence of Hepatitis B and co-existing Hepatitis D and to investigate the pattern of lab parameters among patients positive for hepatitis B and/or D. Methods: This is an observational cross-sectional prospective study conducted from 2009 to 2014 in Lyari General Hospital Karachi Pakistan. A total of 10270 patients were registered in the liver clinic from June 2009 to December 2014 for hepatitis B vaccination. All patients who had visited the Liver clinic of Lyari General Hospital for hepatitis B vaccination were first screened for hepatitis B, and D viruses by HBsAg, and Anti HDV antibodies and anti HCV by ELISA method. Patients who had HBsAg negative were then vaccinated. If HBsAg was found to be positive the patients have been underwent through further tests for the confirmation of hepatitis B and D (Hepatitis B Virus DNA polymerase chain reaction (PCR), hepatitis B e-antigen (HBeAg), hepatitis Be antibody (HBeAb), and if anti HDV positive then HDV RNA PCR was performed). Patients found to have a positive HBVDNA PCR with positive or negative HBeAg were treated. Patients with positive HBeAb were seroconverted. Patients with a positive anti HDV antibody underwent an HDVRNA PCR and if positive were treated. Statistical analysis was performed using SPSS (IBM SPSS Statistics 24.0). Results: A total of 10270 patients were registered in the liver clinic. Overall 206 (2%) were found to be HBV positive, in which 26.2% had Hepatitis D co-infection. More than half (57.3%) were male and 70.4% were married with the mean age of 33.2 ± 10.9 years. About one-fourth of the total were HbeAg positive (25.2%) and hepatitis D antibody positive (26.2%), while 21% had HDV PCR positive and 6.3% had hepatitis C antibody positive. The mean hemoglobin was 12.2, white cell count 6052.3, viral load of HBV DNA was 44100856.97, SGPT was 63.47, albumin was 4.24 and mean INR was 1.09. Conclusion: Prevalence of Hepatitis B infection was 2% and Hepatitis D infection was present in 26.2% of hepatitis B infected patients.

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“…The main etiological factors are alcohol abuse, viral hepatitis and autoimmune diseases. In the last decade, there has been an increase of cases related to cryptogenic liver disease and non-alcoholic fatty liver disease 1,2 .…”

Section: Introduction Hepatic Cirrhosismentioning

confidence: 99%

“…In 2013, HC was the 13th major cause of death in the world, responsible for approximately 1 million deaths (2) . In Brazil, there were 853,751 hospital admissions attributed to CH in the period 2001 and 2010.…”

Section: Introduction Hepatic Cirrhosismentioning

confidence: 99%

Development of an instrument to evaluate the knowledge that the patient with hepatic cirrhosis has about his disease and treatment

Medeiros¹,

Carvalho²,

Nii³

et al. 2018

Rev. Med. (São Paulo)

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Introduction: hepatic cirrhosis (HC) is a disease with high morbidity and mortality in Brazil. Its treatment is complex and requires from lifestyle changes to large surgeries such as liver transplantation. To reach the best treatment results, it is necessary to guarantee a good patient’s adherence to the treatment. Studies indicate that the patient’s self-knowledge about his or her clinical condition is a determining factor in its adherence. Objectives: to assist in the design of an instrument that evaluates knowledge about the disease and treatment of HC. Methodology: The development process of the instrument will be divided into 3 stages: construction of the instrument (1st stage), evaluation of content validity and clarity of the instrument (2nd stage) and assessment of the reliability of the instrument (3 rd stage). Results: an instrument to evaluate the cirrhotic patient knowledge about the disease was made, analyzed by specialists and approved in the criteria proposed. Conclusions: 1) The development of the instrument followed the steps described in literature. 2) The suggestion of the evaluators allowed to restructure the questions making them clearer and more relevant to the proposal of the instrument. 3) it was possible to achieve satisfactorily the proposal of the construction of the instrument.

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Understanding the Complexities of Cirrhosis

Cited by 49 publications

References 107 publications

Surgical Resection of Hepatocellular Carcinoma in Compensated Cirrhotic Liver: The Benefits and Selection Criteria

Surgical Resection of Hepatocellular Carcinoma in Compensated Cirrhotic Liver: The Benefits and Selection Criteria

HBV and HDV Seroprevalence among Healthy People Admitted for Hepatitis B Vaccination

Development of an instrument to evaluate the knowledge that the patient with hepatic cirrhosis has about his disease and treatment

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