Synthetic cannabinoids, also known as “Spice” or “K2,” are a group of recreational substances that elicit cannabimimetic effects similar to delta (9)-tetrahydrocannabinol, the primary psychoactive constituent in cannabis. They are becoming a public health concern because they are toxic and they are not detected by standard urine screening tests. The largest group of users of synthetic cannabinoids are adolescent males who are polysubstance users; however, no data are available concerning use of synthetic cannabinoids in the elderly. We report 2 cases of elderly individuals who used synthetic cannabinoids and were admitted to a psychiatric hospital, and we discuss biopsychosocial factors that may have contributed to abuse of these substances in the elderly.