The dengue virus is the most dangerous one that mosquitoes may spread to people. Despite attempts by the government, dengue outbreaks are becoming increasingly common in Bangladesh. Interventions in public health rely heavily on KAP (knowledge, attitude, and practice) studies. The primary goal of this research is to forecast the occurrence of dengue disease in the city of Dhaka using methods from machine learning and time series analysis and then to compare the models in order to find the one with the lowest MAPE. From January 2016 through July 2021, monthly data were retrieved for this study from WHO and the Directorate General of Health and Services (DGHS). According to the findings of this research, neural networks outperform time series analysis when it comes to making predictions. The best-fitted neural network (NN) model was found in model 04 with 05 hidden layers which produced the minimum error model with the value of error 0.003032557, and the values of RMSE and MAPE are 7.588889e − 06 and 1.15273, respectively, for the prediction of the dengue fever in Dhaka city. In contrast, the original dengue data in the time series analysis is not stationary. Take the difference and run the unit root test by the augmented Dickey–Fuller (ADF) test to make it stationary. The dengue data series is stationary at the first-order difference, as evidenced by the ACF and PACF, which show no noticeable spike in the first-order difference. The ARIMA (6, 1, 1) model with the lowest AIC = −251.8, RMSE = 0.0310797, and MAPE = 15.2892 is the best choice model for predicting the dengue death rate. Therefore, from these two models, the NN model gives better prediction performance with the lowest value of MAPE. So, the neural network gives better prediction performance than time series analysis. The NN model forecasted 12-month death rates of dengue fever that suggest the death rate in dengue fever falling month by month. This study is more innovative than any other research because this research approach is different from any other research approach. The model selection criteria are based on the most effective performance metrics MAPE, indicating the lowest error and better prediction performance. Therefore, from this research, the author suggests machine learning gives better prediction performance than time series analysis for any other prediction performance.
