Understanding the Dynamics of the Developing Adolescent Brain Through Team Science

Zanolie, Kiki; Ma, Ili; Bos, Marieke; Schreuders, Elisabeth; Vandenbroucke, Annelinde R. E.; Hoorn, Jorien van; Duijvenvoorde, Anna C. K. van; Wierenga, Lara M.; Crone, Eveline A.; Güroğlu, Berna

doi:10.3389/fnint.2022.827097

Cited by 6 publications

(3 citation statements)

References 88 publications

(111 reference statements)

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“…Therefore, the work undertaken in this registered report can be used a framework for future studies, whose design should reflect the complex interplay of these processes as much as possible. Given the complexities of development, "team-science" and "open-science" practices will allow us to better understand the aspects of pubertal and brain development that contribute to adolescent mental health vulnerabilities in a reproducible and collaborative manner (Zanolie et al, 2022). Such efforts will be crucial to reaching our collective goal of creating an environment that gives young people every chance to flourish in their development.…”

Section: Discussionmentioning

confidence: 99%

The role of brain structure in the association between pubertal timing and depression risk in an early adolescent sample (the ABCD Study®): A registered report

MacSweeney

Allardyce

Edmondson-Stait

et al. 2023

Developmental Cognitive Neuroscience

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Section: Discussionmentioning

confidence: 99%

The role of brain structure in the association between pubertal timing and depression risk in an early adolescent sample (the ABCD Study®): A registered report

MacSweeney

Allardyce

Edmondson-Stait

et al. 2023

Developmental Cognitive Neuroscience

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“…Blum et al (2012) emphasize contributors to adolescent development through a socioecological framework, including expectations and support at the individual level, interpersonal community assets, and macro-level factors such as policy. Each of these levels of the socioecological framework have been emphasized in recent literature as well, highlighting the importance of social determinants of health and systemic policy for healthy adolescent development (Achterberg et al, 2022; Black et al, 2021; Ferschmann et al, 2022; Hargreaves et al, 2022; Zanolie et al, 2022). Our study demonstrates that adolescent autonomy and independence may be driven by parental preparation and empowerment for adolescent ownership over their own health care.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Complexity of Telehealth Privacy Through a Lens of Adolescent Development

et al. 2023

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Many challenges exist related to ensuring adolescent privacy with health care providers (HCPs), and the rapid integration of telehealth visits has created additional complexities in organizing privacy for adolescents. Through interviews with adolescent patients and their parents ( n = 34), this qualitative analysis aimed to explore the complicated relationship and balance of adolescent alone time with HCPs, parental presence and support, and organization of privacy in order to consider how privacy during telehealth visits may contribute to adolescents’ healthy development. A framework by Blum et al. (2014) proposed four central goals of adolescent development: emotional security, engagement with learning, self-efficacy, and decision-making skills. This conceptual framework was used to outline the ways in which adolescent privacy during telehealth impacts adolescent development. Some adolescents reported that having their parents present during their telehealth visit afforded reassurance and comfort, and many parents explained that they served as a role-model during their adolescent’s telehealth visit. However, other adolescents felt higher emotional security when they could establish an independent relationship with their HCP, with many describing how privacy during their telehealth visit enabled them to have more sensitive discussions with their HCP. Adolescents and parents also reported that telehealth allowed increased experiential learning for adolescents, given their proficiency with technology and ability to access their health care visits autonomously. Furthermore, the organization of privacy was complicated by a lack of understanding whose responsibility it was to facilitate alone time between the adolescent and HCP, as well as external factors such as location and quality of technology and the proximity of family members in the home. By ensuring opportunities for private healthcare encounters, both in telehealth and in-person visits, HCPs and parents can help support adolescents in achieving successful and healthy development.

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“…In Chapter 3, I show that de-identification methods minimally affect subsequent processing in line with another study (Schwarz et al, 2021). The different interacting factors that play a role in development ask for interdisciplinary collaboration and team science (Zanolie et al, 2022). Still, I show that this does not have to come at the cost of the privacy of participants involved in the research.…”

Section: Open Sciencementioning

confidence: 70%

Childhood images

Buimer

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The aim of this thesis was to study sources of inter-individual variation in brain structure and function in pre-adolescence. This thesis focused on several factors that contribute to this variation, including test-retest variability, biological factors such as age and sex, socioemotional skills, and childhood experiences. I used data from 1000 children (8-, 9- and 10-year-olds) participating in the first wave of the YOUth: Child & Adolescent cohort. The first article contains a full description of the YOUth MRI protocol including test-retest reliability of brain measures derived with this protocol (Chapter 2). The information shared in this chapter, such as the state-of-the-art acquisition parameters, extensive quality control procedures and reliability measures, can be useful to the neuroimaging community by aiding to increase the reproducibility and harmonization across developmental neuroimaging studies. The test-retest study using the YOUth MRI protocol in young adults, indeed showed that test-retest reliability was comparable to literature for brain measures derived from all MRI modalities: structural T1-weighted imaging, diffusion-weighted imaging (DWI), resting-state functional MRI and task-based functional MRI. As expected, higher test-retest reliability was found for structural T1-weighted and DWI scans compared to functional brain measures. In the second article different de-identification (defacing) procedures for anatomical MRI data are compared (Chapter 3). De-identification methods remove or blur identifiable facial characteristics on anatomical MRI scans. Implementing de-identification methods enables researchers to share data while protecting participants privacy. I show that de-identification methods introduce some variability in outcome measures, but the reproducibility was comparable to test-retest reliability and no large systematic effects were found. Furthermore, I show that some de-identification methods do not work well on child brain scans. In the third article, I investigated associations between anatomical brain measures and adverse childhood experiences (ACEs) (Chapter 4). An association was found between 2 out of 11 adverse childhood experiences: 1) growing up in a family with alcohol or substance abuse issues, and 2) exposure to violence or crime within the family or neighborhood. For the last article, I used functional neuroimaging data to investigate interrelations between different factors related to social cognition: behavioral emotion labeling, neural processing of emotional faces and social competence (Chapter 5). No relationship was found between these three factors. However, this study did reveal that older children and girls, on average, have better social skills and find it easier to label emotions on faces. To better support children, it is important to understand the biological mechanisms linking childhood experiences to well-being in later life. Overall, associations between inter-individual differences in brain characteristics and behavioral or environmental phenotypes were low, despite the relatively large sample size. The inherently complex associations between the social environment and the developing brain ask for interdisciplinary collaborations, embracing diversity in all aspects, and pooling data to enhance statistical power. Understanding how childhood experiences convey risk for mental health problems later in life can help to identify malleable factors that could ultimately support children growing up. This dissertation includes a summary in Dutch and a summary for young readers in Dutch.

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Understanding the Dynamics of the Developing Adolescent Brain Through Team Science

Cited by 6 publications

References 88 publications

The role of brain structure in the association between pubertal timing and depression risk in an early adolescent sample (the ABCD Study®): A registered report

The role of brain structure in the association between pubertal timing and depression risk in an early adolescent sample (the ABCD Study®): A registered report

Exploring the Complexity of Telehealth Privacy Through a Lens of Adolescent Development

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