Grounded in the multidisciplinary field of strategic risk and health communication, this study proposed and tested a new infectious disease threat (IDT) appraisal model, focused on mapping individuals' coping strategy preferences as predicted by their perceived predictability and controllability of the disease. A 2 (predictability: high vs. low) × 2 (controllability: high vs. low) within-subjects online experimental design (N = 1,032 U.S. adults) was employed, in which four IDT scenarios (sexually transmitted infection [STI]; waterborne ID; foodborne ID; vector-borne ID) were shown to participants in a counterbalanced fashion, to examine the effects of IDT appraisals on how individuals cope with outbreaks. Results support the hypothesized model, in which assessments of predictability, controllability, and responsibility of an IDT situation drive individuals' affect valence, information seeking, and conative reactions in passive and active ways. Findings further provide insights into what information seeking strategies and IDT coping behaviors individuals prefer based on their differential IDT appraisals, thus suggesting how public health authorities and risk communication professionals can optimally communicate about infectious diseases to help individuals understand these situations and respond appropriately. Strategic health and risk communication is an integral part of strategic communication, in which the purposeful use of communication by organizations (e.g., public health authorities) to fulfill their missions plays a pivotal role (Hallahan et al., 2007). As a multidisciplinary domain of research and practice that intersects health communication, risk communication, and public relations, strategic health and risk communication concerns the development, implementation, and assessment of communications (Hallahan et al., 2007) led by organizations on the social, psychological, and physical wellbeing of at-risk populations (Jin et al., 2016). Although a significant number of risk communication studies have appeared in recent health communication literature, few published studies in