Understanding the genetics and epigenetics of bulimia nervosa/bulimia spectrum disorder and comorbid borderline personality disorder (BN/BSD-BPD): a systematic review

McDonald, Sydney

doi:10.1007/s40519-019-00688-7

Cited by 9 publications

(6 citation statements)

References 48 publications

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“…In fact, it is interesting For more information, visit: http://www.prisma-statement.org/ to note how, in the two studies that examined in greater depth the comorbidity between FED and personality clusters (Udo & Grilo, 2019;Valente et al, 2017), a statistically significant association emerges between BPD and FED, in particular with AN and BN. This result, in agreement with other findings in the literature (Martinussen et al, 2016;McDonald, 2019;Shah & Zanarini, 2018;Newton, 2019;Khosravi, 2020), could be due to the multiple facets of BPD and its traits, which covers various clinical areas (APA, 2014;Gestri, Pazzagli, & Ugolini, 2016). According to what was reported in a recent article by Newton (2019) (Newton, 2019) in fact, a comorbidity between BPD and FED emerges, in particular with: 20% of outpatient patients with bingeing / elimination conducts type AN and 50% of patients with BN (Newton, 2019;Maranon, Echeburia, & Grijalvo, 2007).…”

Section: Summary Of Findingssupporting

confidence: 92%

The comorbidity between Feeding and Eating Disorders and Personality Disorders: A systematic review of current status

Spiniello¹,

Sapuppo²

2022

Ijedo

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Purpose of review: to update the state of art about the comorbidity between Feeding and Eating Disorders (FEDs) and Personality Disorders (PDs), referring to the categorical of the latest versions of the Statistical and Diagnostic Manual of Mental Disorders (DSM): DSM-IV, DSM-IV-TR and DSM-5. The following state-of-art literature review has been carried out since 2014, to which is possible to trace the latest findings about the topic. Methods: the present systematic review has been conducted in accordance to PRISMA guidelines. Advanced systematic searches in PubMed and EBSCOhost have been conducted using the following search string with Boolean operators (eating disorders or anorexia or bulimia or binge eating) AND personality disorder AND (comorbidity or comorbidities or cooccurrence or comorbid) NOT (review of literature or literature review or meta-analysis or systematic review). The search strategy garnered four studies for inclusion in the present review, referred between February 2014 and March 2022. Results: the analysis of the 4 studies suggests a comorbidity between FEDs and PDs. While this co-occurrence seems to prevail in a plain population, pre-existence of psychiatric disorders such as ADHD or ASD seem not to have an impact on the comorbidity between the two disorders. Discussion: more in-depth studies on the general co-occurrence between FEDs and PDs can be really helpful to update and synthesise the results on this sketchy topic, not only for the purpose to bring up to date the literature, but also to be ready to treat such disorders that are constantly evolving. RiassuntoObiettivo: aggiornare lo stato dell'arte circa la comorbilità tra Disturbi della Nutrizione e dell'Alimentazione (DNA) e Disturbi di Personalità (DP), facendo riferimento al modello categoriale delle ultime versioni del Manuale Statistico e Diagnostico dei Disturbi Mentali (DSM): DSM-IV, DSM-IV-TR and DSM-5. La seguente revisione sistematica della letteratura è stata condotta a partire dall'anno 2014, al quale è possibile far risalire gli ultimi articoli sull'argomento.Metodo: la seguente revisione sistematica è stata condotta secondo le linee guida PRISMA. Sono state eseguite ricerche sistematiche avanzate su PubMed e EBSCOhost, utilizzando la seguente stringa di ricerca: (eating disorders or anorexia or bulimia or binge eating) AND personality disorder AND (comorbidity or comorbidities or cooccurrence or comorbid) NOT (review of literature or literature review or meta-analysis or systematic review). La seguente strategia di ricerca ha permesso di raccogliere 4 studi da includere nella seguente revisione, nell'intervallo tra Febbraio 2014 e Marzo 2022. Risultati: l'analisi dei 4 studi suggerisce una comorbilità tra i DNA e i DP. Mentre questa co-occorrenza sembra prevalere in una popolazione normale, la pre-esistenza di disturbi psichiatrici come ADHD o ASD non sembra avere impatto nella comorbilità tra le due patologie. Discussione: studi più approfonditi riguardo la co-occorrenza generale tra DNA e DP potrebbero essere d'aiuto ...

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Section: Summary Of Findingssupporting

confidence: 92%

The comorbidity between Feeding and Eating Disorders and Personality Disorders: A systematic review of current status

Spiniello¹,

Sapuppo²

2022

Ijedo

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“…Such effects are reported to occur even when the individual has not had direct contact with the trauma itself or the traumatized relative [85][86][87][88][89]. DNA methylation, which is a measure of epigenetic change and which ostensibly mediates such effects, has been associated with a number of changes in mental illness phenotypic manifestations, including brain structure and function, that are relevant to EDs, PTSD and other trauma-related disorders [76][77][78][90][91][92][93][94][95][96][97][98][99]. Significantly, DNA methylation alterations in AN have been shown to be indicative of chronicity and illness severity but can be 'reset' and normalize with treatment and remission of illness [100].…”

Section: Generational Embodiment (Genetics) / Historical Trauma (Epig...mentioning

confidence: 99%

Mechanisms by which adverse childhood experiences, other traumas and PTSD influence the health and well-being of individuals with eating disorders throughout the life span

Brewerton

2022

J Eat Disord

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Background Multiple published sources from around the world have confirmed an association between an array of adverse childhood experiences (ACEs) and other traumatic events with eating disorders (EDs) and related adverse outcomes, including higher morbidity and mortality. Methods In keeping with this Special Issue’s goals, this narrative review focuses on the ACEs pyramid and its purported mechanisms through which child maltreatment and other forms of violence toward human beings influence the health and well-being of individuals who develop EDs throughout the life span. Relevant literature on posttraumatic stress disorder (PTSD) is highlighted when applicable. Results At every level of the pyramid, it is shown that EDs interact with each of these proclaimed escalating mechanisms in a bidirectional manner that contributes to the predisposition, precipitation and perpetuation of EDs and related medical and psychiatric comorbidities, which then predispose to early death. The levels and their interactions that are discussed include the contribution of generational embodiment (genetics) and historical trauma (epigenetics), social conditions and local context, the ACEs and other traumas themselves, the resultant disrupted neurodevelopment, subsequent social, emotional and cognitive impairment, the adoption of health risk behaviors, and the development of disease, disability and social problems, all resulting in premature mortality by means of fatal complications and/or suicide. Conclusions The implications of these cascading, evolving, and intertwined perspectives have important implications for the assessment and treatment of EDs using trauma-informed care and trauma-focused integrated treatment approaches. This overview offers multiple opportunities at every level for the palliation and prevention of EDs and other associated trauma-related conditions, including PTSD.

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“…A). 19 Altered NR3C1 methylation is associated with early exposure to stress and has the potential to lead to psychological conditions, including major depressive disorder, 20 bipolar disorder, 21 SCZ, 22 post-traumatic stress disorder, 23 bulimia nervosa, 24 and borderline personality disorder. 25 Studies reported that environmental factors causing alterations in epigenetic mechanisms could be related to the HPA axis and suicide.…”

Section: Introductionmentioning

confidence: 99%

The relationship of the methylation status and polymorphism of glucocorticoid receptor gene (NR3C1) with attempted suicide or non-suicidal self-injury patients in schizophrenia

Oyaci,

Yildirim,

Aytac

et al. 2024

Journal of Investigative Medicine

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We aim to investigate the methylation of NR3C1 gene promotor and NR3C1 BclI polymorphism in schizophrenia (SCZ) patients with attempted suicide or non-suicidal self-injury (NSSI). A sample of 112 patients with SCZ were included in the study. SCID-I was used to confirm the diagnosis according to DSM-IV-TR criteria. The patients were evaluated by data forms that had sociodemographic, suicidal behavior, and NSSI information. Methylation-specific PCR was used to identify the methylation of the NR3C1 gene. The analysis of the BclI polymorphism of the NR3C1 gene was evaluated by using the PCR-RFLP. Our results revealed that although the NR3C1 gene methylation was not statistically significantly different, there was a significant difference in NR3C1 genotype distribution between the SCZ groups with and without attempted suicide. SCZ patients carrying the CC genotype had a lower risk of attempted suicide (OR: 0.421; 95% Cl: 0.183–0.970; p=.040), while having the GG genotype in SCZ patients was associated with a higher risk of attempted suicide (OR: 3.785; 95% Cl: 1.107–12.945; p=.042). Additionally, due to NSSI in SCZ patients, there were no significant differences in NR3C1 gene methylation and NR3C1 genotype distribution between the groups. We propose that the NR3C1 BclI polymorphism may be associated with attempted suicide in Turkish patients diagnosed with SCZ.

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Understanding the genetics and epigenetics of bulimia nervosa/bulimia spectrum disorder and comorbid borderline personality disorder (BN/BSD-BPD): a systematic review

Cited by 9 publications

References 48 publications

The comorbidity between Feeding and Eating Disorders and Personality Disorders: A systematic review of current status

The comorbidity between Feeding and Eating Disorders and Personality Disorders: A systematic review of current status

Mechanisms by which adverse childhood experiences, other traumas and PTSD influence the health and well-being of individuals with eating disorders throughout the life span

The relationship of the methylation status and polymorphism of glucocorticoid receptor gene (NR3C1) with attempted suicide or non-suicidal self-injury patients in schizophrenia

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