Understanding the heterogeneous immune repertoire of brain metastases for designing next‐gen therapeutics
Zongjie Wang,
Kangfu Chen
Abstract:Approximately 20% of cancer patients experience brain metastases in the advanced stages as circulating tumor cells migrate to and colonize the brain microvasculature. Due to the challenges associated with biopsies, our understanding of the tumor microenvironment and heterogeneity in brain metastases remains limited, hindering the development of systemic approaches for detection and treatment. Emerging evidence suggests that specific brain metastases induce a substantial level of immune activation and infiltrat… Show more
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