Understanding the impact of cognitive impairment and disease severity on activities of daily living in MS patients with different disability levels

Yazgan, Yonca Zenginler; Tarakçı, Ela; Güngör, Feray; Kürtüncü, Murat

doi:10.1016/j.clineuro.2020.106398

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…Regarding the disease severity, the motor symptoms such as muscle weakness and hand dysfunction worsen as the MS progresses. Additionally, invisible symptoms such as cognitive dysfunction, fatigue, and depression may significantly affect the participation in IADL PwMS (Yazgan et al., 2020). However, most of the participants were of a mild or moderate stage of the disease.…”

Section: Discussionmentioning

confidence: 99%

Translation, cross cultural adaptation, and construct validation of the Arabic version of the Frenchay Activities Index in people with multiple sclerosis

Khalil

Allataifeh

Kanaan

et al. 2021

Physiotherapy Res Intl

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Background and Purpose Assessing functional status in people with multiple sclerosis (PwMS) has a major role in determining how to help patients to reach their optimal level of living independently in the community. The Frenchay Activity Index (FAI) is a commonly used scale to evaluate functional status in rehabilitation research and practice settings. The aim of this study was to translate the FAI into the standard Arabic language through the process of cross‐cultural adaptation and to explore the internal consistency and construct validity of the produced Arabic version of FAI (A‐FAI) among a sample of Arabic‐speaking PwMS. Method The English version of the FAI was translated into Arabic according to the published guidelines. Cronbach's α was used to assess the internal consistency of the A‐FAI, and principal factor analysis was conducted to explore the construct validity. Results Hundred and six subjects participated in the study. The A‐FAI has acceptable internal consistency as Cronbach's α was 0.70. The principal factor analysis revealed that the instrument has four main factors: domestic chore, leisure, hobbies, and work, rather than the original three factors scale. Discussion The A‐FAI has acceptable internal consistency and validity. A‐FAI provides essential information about the participation level in instrumental activities of daily living activities among PwMS speaking the Arabic language.

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Section: Discussionmentioning

confidence: 99%

Translation, cross cultural adaptation, and construct validation of the Arabic version of the Frenchay Activities Index in people with multiple sclerosis

Khalil

Allataifeh

Kanaan

et al. 2021

Physiotherapy Res Intl

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The Prevalence of Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis: A Systematic Review and Meta-analysis

Wu,

Francis,

Lucien

et al. 2024

Neuropsychol Rev

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It is increasingly recognized that cognitive symptoms are a common sequelae of relapsing-remitting multiple sclerosis and are associated with adverse functional consequences. However, estimates of cognitive impairment (CIm) prevalence vary widely. This study aimed to determine the pooled prevalence of CIm among adults with RRMS and investigate moderators of prevalence rates. Following prospective registration (PROSPERO; CRD42021281815), electronic databases (Embase, Scopus, Medline, and PsycINFO) were searched from inception until March 2023. Eligible studies reported the prevalence of CIm among adults with RRMS, as determined through standardized neuropsychological testing and defined as evidence of reduced performance across at least two cognitive domains (e.g., processing speed, attention) relative to normative samples, healthy controls, or premorbid estimates. The electronic database search yielded 8695 unique records, of which 50 met selection criteria. The pooled prevalence of cognitive impairment was 32.5% (95% confidence interval 29.3–36.0%) across 5859 participants. Mean disease duration and age were significant predictors of cognitive impairment prevalence, with samples with longer disease durations and older age reporting higher prevalence rates. Studies which administered more extensive test batteries also reported significantly higher cognitive impairment prevalence. Approximately one third of adults with RRMS experience clinical levels of CIm. This finding supports the use of routine cognitive testing to enable early detection of CIm, and to identify individuals who may benefit from additional cognitive and functional support during treatment planning.

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Semaglutide, a novel glucagon-like peptide-1 agonist, amends experimental autoimmune encephalomyelitis-induced multiple sclerosis in mice: Involvement of the PI3K/Akt/GSK-3β pathway

Sadek

Kandil

Sayed

et al. 2023

International Immunopharmacology

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Understanding the impact of cognitive impairment and disease severity on activities of daily living in MS patients with different disability levels

Cited by 3 publications

References 29 publications

Translation, cross cultural adaptation, and construct validation of the Arabic version of the Frenchay Activities Index in people with multiple sclerosis

Translation, cross cultural adaptation, and construct validation of the Arabic version of the Frenchay Activities Index in people with multiple sclerosis

The Prevalence of Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis: A Systematic Review and Meta-analysis

Semaglutide, a novel glucagon-like peptide-1 agonist, amends experimental autoimmune encephalomyelitis-induced multiple sclerosis in mice: Involvement of the PI3K/Akt/GSK-3β pathway

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