2018
DOI: 10.1016/j.accpm.2018.10.006
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Understanding the impact of pathophysiological alterations during critical illness on drug pharmacokinetics

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Cited by 18 publications
(24 citation statements)
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“…The ARC condition has recently drawn attention due to its prevalence (present in 20–65% of the patients [ 10 , 14 ] in the intensive care setting), and its potential impact on the elimination of the drugs, especially those primarily eliminated by renal excretion. Pharmacokinetics of renally excreted antimicrobials, such as vancomycin, β-lactams or linezolid, have demonstrated to be significantly modified in patients with ARC [ 15 , 16 , 17 , 18 , 19 ], leading to sub-therapeutic concentrations.…”
Section: Discussionmentioning
confidence: 99%
“…The ARC condition has recently drawn attention due to its prevalence (present in 20–65% of the patients [ 10 , 14 ] in the intensive care setting), and its potential impact on the elimination of the drugs, especially those primarily eliminated by renal excretion. Pharmacokinetics of renally excreted antimicrobials, such as vancomycin, β-lactams or linezolid, have demonstrated to be significantly modified in patients with ARC [ 15 , 16 , 17 , 18 , 19 ], leading to sub-therapeutic concentrations.…”
Section: Discussionmentioning
confidence: 99%
“…Our data showed a larger V and faster CL for meropenem than had been reported previously, which could be explained by the fact that critical illness necessitates administration of resuscitative fluids, inotropes, vasopressors, and diuretics. Such administration can cause enhanced blood flow to the kidneys and increased glomerular filtration, which result in increased CL and subtherapeutic concentrations of the drug (7,17).…”
Section: Discussionmentioning
confidence: 99%
“…The altered pathophysiology in critically ill patients can have a major impact on the pharmacokinetic parameters of drugs [ 3 5 ]. One of the phenomena in this population that is gaining relevance is augmented renal clearance (ARC).…”
Section: Introductionmentioning
confidence: 99%