Understanding the Impact of Residual Amblyopia on Functional Vision and Eye-related Quality of Life Using the PedEyeQ

Hatt, Sarah R.; Castañeda, Yolanda S.; Wernimont, Suzanne M.; Liebermann, Laura; Cheng-Patel, Christina S.; Birch, Eileen E.; Holmes, Jonathan M.

doi:10.1016/j.ajo.2020.05.039

Cited by 26 publications

(21 citation statements)

References 31 publications

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“…Our findings accurately outline the clinical reality of postoperative children with congenital and developmental cataracts. For example, we found that nystagmus, strabismus, and amblyopia are all likely to have an impact on peoples' daily activities ( 22 , 28 , 29 ) because reduced visual acuity and stereoacuity all influence their functional vision. Patients with amblyopia are more likely to have a slower reading speed ( 30 ), with those with strabismus being more likely to also exhibit motor skill deficits ( 30 ).…”

Section: Discussionmentioning

confidence: 97%

“…The factor structure and validity, as well as the known-group, discriminant, and convergent validities, of the PedEyeQ have been established in studies of children with bilateral visual impairment ( 6 ), residual amblyopia ( 22 ), strabismus ( 23 ), unilateral visual acuity deficit ( 24 ), and correlational research between functional measures and the Child PedEyeQ ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

“…For example, a series of studies by the American Pediatric Eye Disease Investigator Group reported that the PedEyeQ greatest mean differences are worse in the Functional Vision domain for patients with these conditions. However, they directly explored the association of specific eye conditions, such as strabismus ( 23 ), amblyopia ( 22 ), and nystagmus ( 26 ), with functional vision and ER-QOL in their participants. This means that nystagmus, strabismus, and amblyopia are significant factors in this relationship.…”

Section: Discussionmentioning

confidence: 99%

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A Retrospective Study on the Eye-Related Quality of Life, Functional Vision, and Their Determinants Among Children Following Congenital and Developmental Cataracts Surgery and Its Impact on Their Families Using the PedEyeQ

Zhao

et al. 2022

Front. Public Health

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ObjectivesTo evaluate the eye-related quality of life (ER-QOL), functional vision, and their determinants in children following congenital and developmental cataract surgery, as the impact on their families, using the Pediatric Eye Questionnaire (PedEyeQ).Materials and MethodsThis was a retrospective cross-sectional study involving 107 children (aged 0–11 years) with congenital and developmental cataracts who had undergone surgery, as well as 59 visually healthy controls (aged 0–11 years). One parent for each child completed either the Proxy 0–4 PedEyeQ, the Proxy 5–11 PedEyeQ, or the Parent PedEyeQ, depending on their child's age. Mann-Whitney U and Kruskal-Wallis tests were then conducted to compare the differences between groups and to analyze their determinants.ResultsPedEyeQ scores were found to be lower in postoperative children with congenital and developmental cataracts compared with the control group across all study domains. The PedEyeQ Proxy 0 to 4 years' greatest mean difference was 27 points worse in the Functional Vision domain (95% CI −34 to −19; p < 0.001). We also found that the occurrence of nystagmus (p < 0.005) and strabismus (p < 0.005) were the major factors affecting participants' functional vision. The PedEyeQ Proxy 5 to 11 years' greatest mean difference was 23 points worse in this same domain (95% CI −30 to −15; p < 0.001), with nystagmus (p < 0.05) being the main determinant herein. Parent PedEyeQ 0 to 4 years' greatest difference was 46 points worse on the Worry about their Child's Eye Condition domain (95% CI −57 to −36; p < 0.001). Similarly, parents of children with ophthalmologic abnormalities, including nystagmus (p < 0.001) and strabismus (p < 0.05), were significantly more worried about their children's eye condition. Parent PedEyeQ 5 to 11 years' greatest difference was also found to be 30 points worse on the Worry about their Child's Eye Condition domain (95% CI −43 to −17; p < 0.005).ConclusionsChildren who have undergone congenital and developmental cataract surgery experience a lower quality of life and reduced functional vision. Their families are also significantly and adversely affected herein. Thus, more attention is needed on these groups, with more focused measures being administered to both children and their families.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Retrospective Study on the Eye-Related Quality of Life, Functional Vision, and Their Determinants Among Children Following Congenital and Developmental Cataracts Surgery and Its Impact on Their Families Using the PedEyeQ

Zhao

et al. 2022

Front. Public Health

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“…Recent research has shown that amblyopia not only impacts vision of the affected eye; functional consequences include deficits in the stronger, fellow eye, slow reading, impaired motor skills, and low self-esteem and quality of life (see ''Box'')-all issues that can streamline into a child's everyday life, and persist into adulthood [88,[93][94][95][96][101][102][103][104][105][106][107]. Therefore, it is imperative that this condition be diagnosed and treated as early as possible.…”

Section: What's On the Horizon?mentioning

confidence: 99%

“…Self-Perception and Quality of Life Amblyopia affects children’s self-perception, especially of physical competence and peer acceptance [ 94 – 96 ]. Children with amblyopia and their parents have reduced quality of life scores [ 107 ]. …”

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confidence: 99%

Recent Advances in Screening and Treatment for Amblyopia

2021

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Amblyopia is the most common cause of monocular visual impairment in children, with a prevalence of 2-3%. Not only is visual acuity reduced in one eye but binocular vision is affected, fellow eye deficits may be present, eye-hand coordination and reading can be affected, and self-perception may be diminished. New technologies for preschool vision screening hold promise for accessible, early, and accurate detection of amblyopia. Together with recent advances in our theoretical understanding of amblyopia and technological advances in amblyopia treatment, we anticipate improved visual outcomes for children affected by this very common eye condition. This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors.

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