Understanding the influence of alendronate on the morphology and phase transformation of apatitic precursor nanocrystals

Zhang, Guiling; Li, Zhicheng; Yang, Xianyan; Chen, Xiaoyi; Xia, Wei; Sun, Xin; Gao, Yang; Gao, Changyou; Gou, Zhongru

doi:10.1016/j.jinorgbio.2012.03.011

Cited by 14 publications

(3 citation statements)

References 41 publications

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“…First, after IBU loading, the characteristic peak of CO of IBU shifted from 1720 to 1560 cm –1 , which is attributed to the polarity changes of the −COOH group (linked to CSH). Besides, the Si–O stretching is blue-shifted, which is ascribed to the polarity change of Si–O–Si (formation of Si–O–C, magenta arrows). ,, Second, the characteristic absorption peaks of pure ALN molecules at 1020 and 1050 cm –1 (PO stretching vibration, indicated by the navy arrows) are present, and after ALN loading, new absorption peaks were observed at 961 and 1084 cm –1 (in cyan arrows), which are assigned to P–O stretching (PO 4 3– ) . Third, the major absorption peaks of pure GS were at 619 and ∼1100 cm –1 (dark cyan arrows), and compared with the CSH FTIR spectrum (black), a new broad peak was observed at ∼1115 cm –1 (green), which belongs to the bands of sulfate ions.…”

Section: Resultsmentioning

confidence: 96%

“…). 49 Third, the major absorption peaks of pure GS were at 619 and ∼1100 cm −1 (dark cyan arrows), 50 and compared with the CSH FTIR spectrum (black), a new broad peak was observed at ∼1115 cm −1 (green), which belongs to the bands of sulfate ions. All these observations are in good agreement with the XANES results discussed above; however, only parts of interactions can be confirmed because of the overlapping of absorption bands.…”

Section: −mentioning

confidence: 97%

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Tracking Drug Loading Capacities of Calcium Silicate Hydrate Carrier: A Comparative X-ray Absorption Near Edge Structures Study

Guo

Wang

et al. 2015

J. Phys. Chem. B

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Mesoporous spheres of calcium silicate hydrate (MS-CSH) have been prepared by an ultrasonic method. Following an earlier work in which we have revealed the interactions between ibuprofen (IBU) and CSH carriers with different morphologies by X-ray absorption near edge structures (XANES) analysis. In the present investigation, two new drug molecules, alendronate sodium (ALN) and gentamicin sulfate (GS), were incorporated into MS-CSH, and their drug loading capacities (DLCs) were measured using thermogravimetric analysis to establish the relationship between drug-carrier interactions and DLCs. The XANES spectra clearly indicate that acidic functional groups of the drug molecules linked to the active sites (Ca-OH and Si-OH groups) of MS-CSH on the surface by electrostatic interactions. In addition, it is found that the stoichiometric ratio of Ca(2+) ions of CSH carriers and the functional groups of drug molecules may significantly influence the DLCs.

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Section: Resultsmentioning

confidence: 96%

Section: −mentioning

confidence: 97%

Tracking Drug Loading Capacities of Calcium Silicate Hydrate Carrier: A Comparative X-ray Absorption Near Edge Structures Study

Guo

Wang

et al. 2015

J. Phys. Chem. B

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“…This was elegantly proven by the noticed acceleration of phase transformations by stirring and their slowing down by substituting water with nonpolar solvents 23 and later supported by the ability of organic adsorbates, such as alendronate sodium, to extend the phase transformation timescale from minutes to days 24 . The complementary mechanism, on the other hand, similar in nature to the martensitic/austenitic transition involving bulk lattice rearrangements, is still the subject of debate.…”

Section: Peculiarities Of Hapmentioning

confidence: 97%

The role of hydroxyl channel in defining selected physicochemical peculiarities exhibited by hydroxyapatite

Uskoković

2015

RSC Adv.

123

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Mysteries surrounding the most important mineral for the vertebrate biology, hydroxyapatite, are many. Perhaps the Greek root of its name, απαταo, meaning ‘to deceive’ and given to its mineral form by the early gem collectors who confused it with more precious stones, is still applicable today, though in a different connotation, descriptive of a number of physicochemical peculiarities exhibited by it. Comparable to water as the epitome of peculiarities in the realm of liquids, hydroxyapatite can serve as a paradigm for peculiarities in the world of solids. Ten of the peculiar properties of hydroxyapatite are sketched in this review piece, ranging from (i) the crystal lattice flexibility to (ii) notorious surface layer instability to (iii) finite piezoelectricity, pyroelectricity and conductivity to protons to (iv) accelerated growth and improved osteoconductivity in the electromagnetic fields to (v) high nucleation rate at low supersaturations and low crystal growth rate at high supersaturations to (vi) higher bioactivity and resorbability of biological apatite compared to the synthetic ones, and beyond. An attempt has been made to explain this array of curious characteristics by referring to a particular element of the crystal structure of hydroxyapatite: the hydroxyl ion channel extending in the direction of the c-axis, through a crystallographic column created by the overlapping calcium ion triangles.

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Two‐Step pH‐Modulated Rapid Assembly of Trace‐Element‐Doped Calcium‐Phosphate Nanocrystals into Giant Porous Beads in Gelatin Hydrosol for Biomedical Applications

Chen

Yao

et al. 2013

Chemistry An Asian Journal

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Biomolecule-ion interactions that occur during changes in pH value are a crucial but poorly investigated area that underlies the aggregation of inorganic nanocrystals. Meanwhile, the disorderly growth of calcium phosphate (CaP) nanocrystals is an obstacle that limits its practical applications. Herein, we have demonstrated for the first time that a simple two-step pH-adjustment process for a gelatin hydrosol reaction medium can modulate the ordered self-assembly of trace-element-doped CaP nanocrystals into porous beads. Two methods are used to adjust the initial pH value of gelatin hydrosol: One is to firstly adjust the pH value to 3.0 and then to 4.0 with acid/base solutions, whilst the other is to directly adjust the pH value to 4.0 with acid. Spherical CaP porous beads are rapidly produced through the two-step pH-adjustment process, whereas the one-step pathway results in disorderly CaP aggregates. We believe that the introduction of additives for pH adjustment is the dominant factor in disturbing the electrokinetic parameters and for driving the self-assembly of nanocrystals, whereas the nucleation of CaP nanocrystals prior to assembly is caused by the relaxation/condensation of the polypeptide network, owing to the increase in pH value on the introduction of the basic calcium salt. This method is facile and rapid and these highly bioactive porous beads are particularly promising for use in hard-tissue repair, tissue engineering, and drug delivery.

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Understanding the influence of alendronate on the morphology and phase transformation of apatitic precursor nanocrystals

Cited by 14 publications

References 41 publications

Tracking Drug Loading Capacities of Calcium Silicate Hydrate Carrier: A Comparative X-ray Absorption Near Edge Structures Study

Tracking Drug Loading Capacities of Calcium Silicate Hydrate Carrier: A Comparative X-ray Absorption Near Edge Structures Study

The role of hydroxyl channel in defining selected physicochemical peculiarities exhibited by hydroxyapatite

Two‐Step pH‐Modulated Rapid Assembly of Trace‐Element‐Doped Calcium‐Phosphate Nanocrystals into Giant Porous Beads in Gelatin Hydrosol for Biomedical Applications

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