Understanding the Influence of Pain and Fatigue On Physical performance, Fear of Falling and Falls in People With Parkinson’s Disease: A Pilot Study

Khalil, Hanan; Alissa, Nesreen; Al‐Sharman, Alham; E’Leimat, Islam; Qawasmeh, Majdi Al; El‐Salem, Khalid

doi:10.2217/nmt-2020-0053

Cited by 7 publications

(12 citation statements)

References 60 publications

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“…Our results confirm this association, with a 10% increase in risk of falls for every 1-point increase in fatigue score. Our study finding is consistent with previous research in other nervous system conditions such as multiple sclerosis (MS) [ 30 ] and Parkinson’s disease [ 31 ]. Research has shown that individuals affected by MS who indicated high fatigue levels performed significantly worse on tests of balance and had more falls in a 6-month period compared to those with low fatigue levels [ 30 ].…”

Section: Discussionsupporting

confidence: 93%

“…Our results confirm this association, with a 10% increase in risk of falls for every 1-point increase in fatigue Table 2 The association between demographic characteristics and having had a fall in the previous 12 months A Missing area of residence data for 9 participants (6 who did not have a fall and 3 who did have a fall) B Missing marital status data for 9 participants (5 who did not have a fall and 3 who did have a fall) C Missing educational qualification data for 5 participants (2 who did not have a fall and 3 who did have a fall) score. Our study finding is consistent with previous research in other nervous system conditions such as multiple sclerosis (MS) [30] and Parkinson's disease [31]. Research has shown that individuals affected by MS who indicated high fatigue levels performed significantly worse on tests of balance and had more falls in a 6-month period compared to those with low fatigue levels [30].…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 82%

“…Research has shown that individuals affected by MS who indicated high fatigue levels performed significantly worse on tests of balance and had more falls in a 6-month period compared to those with low fatigue levels [30]. Similar observations have been made in patients with Parkinson's disease where severity of fatigue was related to an increased number of falls [31]. Several explanations have been hypothesised for the association between fatigue and risk of falls in older adults including gait control, daytime sleepiness, pain, anaemia, and metabolic disorders [32].…”

Section: Discussionmentioning

confidence: 56%

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The association between fatigue severity and risk of falls among middle-aged and older Australian stroke survivors

et al. 2022

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Background Fatigue is a common and often debilitating symptom experienced by many stroke survivors. Significant post stroke fatigue may predispose individuals to other health complications, such as falls, which can lead to fractures and soft tissue injuries. Only limited research has examined the association between fatigue and falls in stroke survivors. Methods Data were obtained from the Sax Institute’s 45 and Up Study, from a subset of individuals who had experienced a stroke. The Modified Fatigue Impact Scale—5-item version (MFIS-5) was used to measure the level of fatigue. A logistic regression model, adjusted for stroke characteristics and comorbidities, was used to determine the magnitude of association between change in fatigue score and odds of having had a fall. Results A total of 576 participants completed the questionnaire. A total of 214 (37.2%) participants reported having had a fall in the previous 12 months. There was a statistically significant association between fatigue scores and fall status (p < 0.001). Specifically, for every 1-point increase in the fatigue score (MFIS-5) (i.e. higher level of fatigue), the odds of a person having a fall is 1.10 times greater (AOR = 1.10; 95% CI 1.05, 1.15; p < 0.001). Conclusion This study revealed an association between an increasing risk of falls with increasing severity of post stroke fatigue. Accurate detection and management of fatigue may help reduce the risk of falls and should be the focus of future research.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 56%

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The association between fatigue severity and risk of falls among middle-aged and older Australian stroke survivors

et al. 2022

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“…Falls efficacy measures older person's perceptions of his or her capabilities in not falling when performing some activities in different environments ( 15 ). Research on fatigue and falls efficacy showed that fatigue was significantly associated with falls efficacy ( P -value ≤ 0.002) ( 16 ). Fatigued individuals reported significantly higher falls efficacy scale (FES) ( P -value < 0.05), indicating less confidence in the performance of daily activities without falling ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

Association Between Fatigue and Falls Risk Among the Elderly Aged Over 75 Years in China: The Chain Mediating Role of Falls Efficacy and Lower Limb Function

Zhang

Song

et al. 2022

Front. Public Health

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BackgroundAlthough fatigue has been shown to be strongly associated with falls risk, very few studies have focused on its mechanism involved in community-dwelling older subjects. The purpose of this study was to explore the relationship between fatigue and falls risk and its internal mechanism by constructing a chain mediation model.MethodsA cross-sectional study design was adopted. A convenience sample of 270 older adults was recruited from July to October 2021 in an urban community, in Beijing, China. The participants completed the 14-item Fatigue Scale (FS-14), Falls Efficacy Scale International (FES-I), the Short Physical Performance Battery (SPPB) and Fall-Risk Self-Assessment Questionnaire (FRQ) to measure fatigue, falls efficacy, lower limb function and falls risk. The theory of unpleasant symptoms was used as a conceptual framework. Structural equation modeling (SEM) was utilized to test the hypothetical model.ResultsThe overall fit of final model was found to be satisfactory: χ2/df = 1.61, CFI = 0.971, TLI = 0.962, RMSEA = 0.049 (95% CI 0.030/0.066) and SRMR = 0.023. Fatigue had a direct effect on falls risk (β = 0.559, S.E. = 0.089, 95% CI 0.380/0.731), and it also had indirect effects on falls risk (β = 0.303, S.E. = 0.072, 95% CI 0.173/0.460) through mediating factors. Falls efficacy and lower limb function were the main mediating variables, and there was a chain mediating effect (β = 0.015, S.E. = 0.010, 95% CI 0.003/0.046).ConclusionsOur study suggests that fatigue can influence falls risk among the elderly in China. There are many mediating paths between fatigue and falls risk. These results may help healthcare professionals to better understand the inherent relationship between fatigue and fall risk that may benefit older adults.

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Prevention of Falls in Parkinson's Disease: Guidelines and Gaps

Camicioli

Morris

Pieruccini‐Faria

et al. 2023

Movement Disord Clin Pract

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BackgroundPeople living with Parkinson's disease (PD) have a high risk for falls.ObjectiveTo examine gaps in falls prevention targeting people with PD as part of the Task Force on Global Guidelines for Falls in Older Adults.MethodsA Delphi consensus process was used to identify specific recommendations for falls in PD. The current narrative review was conducted as educational background with a view to identifying gaps in fall prevention.ResultsA recent Cochrane review recommended exercises and structured physical activities for PD; however, the types of exercises and activities to recommend and PD subgroups likely to benefit require further consideration. Freezing of gait, reduced gait speed, and a prior history of falls are risk factors for falls in PD and should be incorporated in assessments to identify fall risk and target interventions. Multimodal and multi‐domain fall prevention interventions may be beneficial. With advanced or complex PD, balance and strength training should be administered under supervision. Medications, particularly cholinesterase inhibitors, show promise for falls prevention. Identifying how to engage people with PD, their families, and health professionals in falls education and implementation remains a challenge. Barriers to the prevention of falls occur at individual, environmental, policy, and health system levels.ConclusionEffective mitigation of fall risk requires specific targeting and strategies to reduce this debilitating and common problem in PD. While exercise is recommended, the types and modalities of exercise and how to combine them as interventions for different PD subgroups (cognitive impairment, freezing, advanced disease) need further study.This article is protected by copyright. All rights reserved.

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Understanding the Influence of Pain and Fatigue On Physical performance, Fear of Falling and Falls in People With Parkinson’s Disease: A Pilot Study

Cited by 7 publications

References 60 publications

The association between fatigue severity and risk of falls among middle-aged and older Australian stroke survivors

The association between fatigue severity and risk of falls among middle-aged and older Australian stroke survivors

Association Between Fatigue and Falls Risk Among the Elderly Aged Over 75 Years in China: The Chain Mediating Role of Falls Efficacy and Lower Limb Function

Prevention of Falls in Parkinson's Disease: Guidelines and Gaps

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