Understanding the interaction of multi-walled carbon nanotubes with mutagenic organic pollutants using computational modeling and biological experiments

Umbuzeiro, Gisela de Aragão; Coluci, V. R.; Honório, J.G.; Giro, Ronaldo; Morales, Daniel Alexandre; Lage, A.S.G.; Mazzei, José Luiz; Felzenszwalb, Israel; Filho, A. G. Souza; Stéfani, Diego; Alves, Oswaldo Luiz

doi:10.1016/j.trac.2010.11.013

Cited by 29 publications

(22 citation statements)

References 72 publications

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“…34–36 MWCNT association with cell envelopes of bacteria without internalized MWCNTs has been demonstrated by other researchers using transmission electron microscopy. 37, 38 Since MWCNTs did not damage the bacterial membranes (Figure S3), the MWCNTs were assumed not to enter bacterial cells. Thus, MWCNT adsorption to the cell surface rather than accumulation inside bacteria is a plausible scenario for the trophic transfer of MWCNTs.…”

Section: Resultsmentioning

confidence: 99%

Bioaccumulation of Multiwall Carbon Nanotubes in Tetrahymena thermophila by Direct Feeding or Trophic Transfer

Mortimer

Petersen

Buchholz

et al. 2016

Environ. Sci. Technol.

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Consumer goods contain multiwall carbon nanotubes (MWCNTs) that could be released during product life cycles into the environment, where their effects are uncertain. Here, we assessed MWCNT bioaccumulation in the protozoan Tetrahymena thermophila via trophic transfer from bacterial prey (Pseudomonas aeruginosa) versus direct uptake from growth media. The experiments were conducted using 14C-labeled MWCNT (14C-MWCNT) doses at or below 1 mg/L, which proved subtoxic since there were no adverse effects on the growth of the test organisms. A novel contribution of this study was the demonstration of the ability to quantify MWCNT bioaccumulation at low (sub µg/kg) concentrations accomplished by employing accelerator mass spectrometry (AMS). After the treatments with MWCNTs at nominal concentrations of 0.01 mg/L and 1 mg/L, P. aeruginosa adsorbed considerable amounts of MWCNTs: (0.18 ± 0.04) µg/mg and (21.9 ± 4.2) µg/mg bacterial dry mass, respectively. At the administered MWCNT dose of 0.3 mg/L, T. thermophila accumulated up to (0.86 ± 0.3) µg/mg and (3.4 ± 1.1) µg/mg dry mass by trophic transfer and direct uptake, respectively. Although MWCNTs did not biomagnify in the microbial food chain, MWCNTs bioaccumulated in the protozoan populations regardless of the feeding regime, which could make MWCNTs bioavailable for organisms at higher trophic levels.

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Section: Resultsmentioning

confidence: 99%

Bioaccumulation of Multiwall Carbon Nanotubes in Tetrahymena thermophila by Direct Feeding or Trophic Transfer

Mortimer

Petersen

Buchholz

et al. 2016

Environ. Sci. Technol.

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“…used ab initio methods to investigate the π-stacking interaction of the planar polycyclic aromatic hydrocarbons benzene, pyrene and azulene with SWCNTs. Umbuzeiro et al (2011) applied computational modeling to 1-nitropyrene and MWCNTs and found that physisorption at defect free MWCNT regions appeared to be the main interaction mechanism. Fagan et al (2004) used calculations from first-principles to study the structural and electronic behavior of the interaction between 1,2-dichlorobenzene (DCB) and SWCNTs.…”

Section: Mechanisms Of Interaction Between Contaminants and Carbon Namentioning

confidence: 99%

Organic contaminants and carbon nanoparticles: sorption mechanisms and impact parameters

Peng

Zhang

et al. 2014

J. Zhejiang Univ. Sci. A

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Carbon nanoparticles (CNPs) are novel manufactured materials with unique properties and have potential for a variety of applications. Adsorption of organic contaminants by discharged CNPs may affect the fate and transport of organic contaminants in the environment. This review summarizes the present research progress regarding organic contaminant adsorption on CNPs, and provides important information for the evaluation of the environmental behavior of organic contaminants and the risks associated with the use of CNPs. The main adsorption mechanisms involve hydrophobic interactions, π-π interactions, hydrogen bonds, and electrostatic interactions. These interactions may exist simultaneously, while the controlling adsorption mechanism differs depending on the properties of both the organic contaminants and the CNPs along with environmental conditions. The status of CNPs in the environment greatly affects or even controls their characteristics for adsorption of organic contaminants. The mobility and transport of dispersed CNPs and CNP-adsorbed organic contaminants could be promoted in natural aqueous environments, potentially increasing the spread of various organic contaminants and their associated environmental risks. Investigating the adsorption mechanisms and impact parameters is vital in predicting the environmental behaviors of both organic contaminants and CNPs and their associated risks.

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“…Therefore, data from the literature demonstrate the necessity of using efficient purification methods for these materials before their applications in biological systems. In this context, recent publications indicate the importance of obtaining well‐characterized nanostructures previous to biological interaction studies 38…”

Section: Biodegradation Of Carbon Nanotubes By Peroxidasesmentioning

confidence: 99%

Redox‐enzymes, cells and micro‐organisms acting on carbon nanostructures transformation: A mini‐review

Seabra

Paula

Durán

2013

Biotechnology Progress

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Carbon nanotubes, graphene and fullerenes are actual nanomaterials with many applications in different industrial areas, with increasing potentialities in the field of nanomedicine. Recently, different proactive approaches on toxicology and safety management have become the focus of intense interest once the industrial production of these materials had a significant growth in the last years, even though their short- and long-term behaviors are not yet fully understood. The most important concerns involving these carbon-based nanomaterials are their stability and potential effects of their life cycles on animals, humans, and environment. In this context, this mini review discuss the biodegradability of these materials, particularly through redox-enzymes, micro-organisms and cells, to contribute toward the design of biocompatible and biodegradable functionalized carbon nanostructures, in order to use these materials safely and with minimum impact on the environment.

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Understanding the interaction of multi-walled carbon nanotubes with mutagenic organic pollutants using computational modeling and biological experiments

Cited by 29 publications

References 72 publications

Bioaccumulation of Multiwall Carbon Nanotubes in Tetrahymena thermophila by Direct Feeding or Trophic Transfer

Bioaccumulation of Multiwall Carbon Nanotubes in Tetrahymena thermophila by Direct Feeding or Trophic Transfer

Organic contaminants and carbon nanoparticles: sorption mechanisms and impact parameters

Redox‐enzymes, cells and micro‐organisms acting on carbon nanostructures transformation: A mini‐review

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