Understanding the mechanisms of treatment response in depression, focus on electro-convulsive therapy

Binder, Elisabeth B.

doi:10.1007/s00406-020-01184-1

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…Depression is a complex, multifactorial, heterogeneous disorder, with a relatively high ratio of treatment-resistance ( McIntyre et al, 2014 ). Although it is known that anti-inflammatory mechanisms are involved in the treatment response of depression, current therapies are still mainly “one fits all” approaches targeting monoaminergic pathways ( van Buel et al, 2015 ; Otte et al, 2016 ; Wohleb et al, 2016 ; Kruse et al, 2018 ; Binder, 2020 ; Nettis et al, 2021 ). To progress toward an effective application of P2X7R -targeting drugs in a clinical setting, there is a need to understand the involvement of P2X7R in psychiatric disorders ( Deussing and Arzt, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

P2X7 Receptor-Related Genetic Mouse Models – Tools for Translational Research in Psychiatry

Urbina-Treviño

Mücke-Heim

Deussing

2022

Front. Neural Circuits

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Depression is a common psychiatric disorder and the leading cause of disability worldwide. Although treatments are available, only about 60% of treated patients experience a significant improvement in disease symptoms. Numerous clinical and rodent studies have identified the purinergic P2X7 receptor (P2X7R) as one of the genetic factors potentially contributing to the disease risk. In this respect, genetically engineered mouse models targeting the P2X7R have become increasingly important in studying designated immunological features and subtypes of depression in vivo. This review provides an overview of the P2X7R -related mouse lines currently available for translational psychiatric research and discusses their strengths, weaknesses, and potentials.

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Section: Discussionmentioning

confidence: 99%

P2X7 Receptor-Related Genetic Mouse Models – Tools for Translational Research in Psychiatry

Urbina-Treviño

Mücke-Heim

Deussing

2022

Front. Neural Circuits

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Multiomics and blood-based biomarkers of electroconvulsive therapy in severe and treatment-resistant depression: study protocol of the DetECT study

von Mücke-Heim,

Pape,

Grandi

et al. 2023

Eur Arch Psychiatry Clin Neurosci

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Electroconvulsive therapy (ECT) is commonly used to treat treatment-resistant depression (TRD). However, our knowledge of the ECT-induced molecular mechanisms causing clinical improvement is limited. To address this issue, we developed the single-center, prospective observational DetECT study (“Multimodal Biomarkers of ECT in TRD”; registered 18/07/2022, www.clinicalTrials.gov, NCT05463562). Its objective is to identify molecular, psychological, socioeconomic, and clinical biomarkers of ECT response in TRD. We aim to recruit n = 134 patients in 3 years. Over the course of 12 biweekly ECT sessions (± 7 weeks), participant blood is collected before and 1 h after the first and seventh ECT and within 1 week after the twelfth session. In pilot subjects (first n = 10), additional blood draws are performed 3 and 6 h after the first ECT session to determine the optimal post-ECT blood draw interval. In blood samples, multiomic analyses are performed focusing on genotyping, epigenetics, RNA sequencing, neuron-derived exosomes, purines, and immunometabolics. To determine clinical response and side effects, participants are asked weekly to complete four standardized self-rating questionnaires on depressive and somatic symptoms. Additionally, clinician ratings are obtained three times (weeks 1, 4, and 7) within structured clinical interviews. Medical and sociodemographic data are extracted from patient records. The multimodal data collected are used to perform the conventional statistics as well as mixed linear modeling to identify clusters that link biobehavioural measures to ECT response. The DetECT study can provide important insight into the complex mechanisms of ECT in TRD and a step toward biologically informed and data-driven-based ECT biomarkers.

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The P2X7 receptor in mood disorders: Emerging target in immunopsychiatry, from bench to bedside

Mücke-Heim

Deussing

2023

Neuropharmacology

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Understanding the mechanisms of treatment response in depression, focus on electro-convulsive therapy

Cited by 4 publications

References 10 publications

P2X7 Receptor-Related Genetic Mouse Models – Tools for Translational Research in Psychiatry

P2X7 Receptor-Related Genetic Mouse Models – Tools for Translational Research in Psychiatry

Multiomics and blood-based biomarkers of electroconvulsive therapy in severe and treatment-resistant depression: study protocol of the DetECT study

The P2X7 receptor in mood disorders: Emerging target in immunopsychiatry, from bench to bedside

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