Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals: From experimental models to clinical trials

Maru, Girish B.; Hudlikar, Rasika R.; Kumar, Gaurav; Gandhi, Khushboo; Mahimkar, Manoj B.

doi:10.4331/wjbc.v7.i1.88

Cited by 94 publications

(64 citation statements)

References 110 publications

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“…They show low or no toxicity and are present in commonly consumed food, which makes them very interesting agents, although unfortunately they have limited bioavailability and bioefficacy [64,65].…”

Section: Dietary Compoundsmentioning

confidence: 99%

Chemoprevention and Treatment of Pancreatic Cancer: Update and Review of the Literature

Benzel

Fendrich

2018

Digestion

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Background: Pancreatic ductal adenocarcinoma is one of the most lethal types of cancer with a 5-year survival rate of around 7%. Due to the relatively poor prognosis, the potential need of an effective chemoprevention is highly needed. Summary: Different risk factors like smoking or hereditary tumour syndromes should be known for early detection of pancreatic intraepithelial neoplasia. Chemopreventive dietary agents include curcumin, capsaicin and flavonoid, whereas potential chemopreventive drugs compromise aspirin, metformin or statins. This review aims to give an overview on potential risk factors for the development of pancreatic cancer. Furthermore, we try to summarise known chemopreventive agents to support the fight against this lethal disease. Key Messages: On the one hand, there are natural agents that exhibit preventive properties and can lead to the prohibition of pancreatic cancer. On the other hand, there are drugs and agents that are currently used in other contexts and are thus already approved and studied in terms of their mechanisms of effects and the related secondary effects.

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Section: Dietary Compoundsmentioning

confidence: 99%

Chemoprevention and Treatment of Pancreatic Cancer: Update and Review of the Literature

Benzel

Fendrich

2018

Digestion

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“…This plurality of molecular targets associated to polyphenols have been generating divergent opinions in literature about the real contribution that such phytochemicals may have in anticancer therapy [37,145,410,411,412,413]. Nonetheless, there are a number of reviews in literature that highlight the cancer chemoprevention effect exerted by these polyphenols [414,415,416,417,418,419]. This chemopreventive effect has been associated to the anti-inflammatory properties of these phytochemicals, especially through the antioxidant activity [420,421,422,423].…”

Section: Perspectivesmentioning

confidence: 99%

Unraveling the Anticancer Effect of Curcumin and Resveratrol

et al. 2016

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Resveratrol and curcumin are natural products with important therapeutic properties useful to treat several human diseases, including cancer. In the last years, the number of studies describing the effect of both polyphenols against cancer has increased; however, the mechanism of action in all of those cases is not completely comprehended. The unspecific effect and the ability to interfere in assays by both polyphenols make this challenge even more difficult. Herein, we analyzed the anticancer activity of resveratrol and curcumin reported in the literature in the last 11 years, in order to unravel the molecular mechanism of action of both compounds. Molecular targets and cellular pathways will be described. Furthermore, we also discussed the ability of these natural products act as chemopreventive and its use in association with other anticancer drugs.

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“…Cancer prevention approaches prescribe natural/synthetic agent(s) with the aim to delay or disrupt the pathways and processes involved at multiple steps, such as the initiation, promotion, and progression of cancer [11]. Even our fresh fruits and vegetables are being depleted of essential minerals and vitamins, often necessitating supplementation [12].…”

Section: Introductionmentioning

confidence: 99%

Anticancer Effects of Curcumin, Artemisinin, Genistein, and Resveratrol, and Vitamin C: Free Versus Liposomal Forms

Thornthwaite¹,

Shah²,

England³

et al. 2017

ABC

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Cancer prevention supplements, which also provide effective treatment with minimal side effects, are urgently needed. An accurate, fast assay system is described that reveals the ability of chemically defined products, such as curcumin, genistein, resveratrol, artemisinin, and vitamin C, to kill K562 Erythroleukemic cells in vitro. In addition, curcumin and vitamin C were encapsulated into fatty acid micelles named NutraNanoSpheres TM (NNS) using all natural products. A unique viability stain, which allows the rapid staining of dead cells by membrane penetration using Propidium Iodide, was used to measure the cell viability by flow cytometry. Cell death by alteration of the cell membranes could be seen within 30 s of exposure to curcumin. The other free components required 0.5 -70 h to see maximum killing, suggesting a more metabolic and/or apoptotic route of cancer cell destruction. Vitamin C up to 1 × 10 4 µmol/well did not affect K562 cell viability. The vitamin C-NNS (3.2 nm diameter-60 mg/50 µL) showed an LD 50 = 133 µmol/well ± 11 SD (n = 4), which was over 75 times more potent than the free vitamin C. The curcumin-NNS (7.4 nm diameter-25 mg/50 µL) resulted in an LD 50 = 41.3 µmol/well ± 5.6 SD (n = 8) and represented a 264 fold increase in activity to destroy the cancer cells. The clinical goal is to develop water-soluble mixtures of anti-cancer compounds in the NNS with their high bioavailability (>90%) and without degradation in the stomach for preventing and curing cancer.

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Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals: From experimental models to clinical trials

Cited by 94 publications

References 110 publications

Chemoprevention and Treatment of Pancreatic Cancer: Update and Review of the Literature

Chemoprevention and Treatment of Pancreatic Cancer: Update and Review of the Literature

Unraveling the Anticancer Effect of Curcumin and Resveratrol

Anticancer Effects of Curcumin, Artemisinin, Genistein, and Resveratrol, and Vitamin C: Free Versus Liposomal Forms

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