Understanding the multifaceted role of miRNAs in Alzheimer’s disease pathology

Kaur, Sharanjot; Verma, Harkomal; Kaur, Sukhchain; Gangwar, Prabhakar; Yadav, Anuradha; Yadav, Bharti; Rao, Rashmi; Dhiman, Monisha; Mantha, Anil Kumar

doi:10.1007/s11011-023-01265-9

Cited by 4 publications

(1 citation statement)

References 192 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…OPPs. [161] Furthermore, miRNAs, known for their stability at room temperature and prolonged existence, have been proposed as molecular biomarkers to monitor both exposure and disease status. [162] A study conducted by Zhao et al on human neuroblastoma SH-SY5Y cells suggests that exposure to OPPs like CP can lead to adverse effects such as impeded proliferation of cells, elevated vulnerability to oxidative stress-associated toxicity, and promotion of cell apoptosis.…”

Section: Opps-induced Micro-rna (Mirna) Dysregulation: Unveiling the ...mentioning

confidence: 99%

Implications of organophosphate pesticides on brain cells and their contribution toward progression of Alzheimer's disease

Yadav,

Kaur,

Yadav

et al. 2024

J Biochem & Molecular Tox

Self Cite

View full text Add to dashboard Cite

The most widespread neurodegenerative disorder, Alzheimer's disease (AD) is marked by severe behavioral abnormalities, cognitive and functional impairments. It is inextricably linked with the deposition of amyloid β (Aβ) plaques and tau protein in the brain. Loss of white matter, neurons, synapses, and reactive microgliosis are also frequently observed in patients of AD. Although the causative mechanisms behind the neuropathological alterations in AD are not fully understood, they are likely influenced by hereditary and environmental factors. The etiology and pathogenesis of AD are significantly influenced by the cells of the central nervous system, namely, glial cells and neurons, which are directly engaged in the transmission of electrical signals and the processing of information. Emerging evidence suggests that exposure to organophosphate pesticides (OPPs) can trigger inflammatory responses in glial cells, leading to various cascades of events that contribute to neuroinflammation, neuronal damage, and ultimately, AD pathogenesis. Furthermore, there are striking similarities between the biomarkers associated with AD and OPPs, including neuroinflammation, oxidative stress, dysregulation of microRNA, and accumulation of toxic protein aggregates, such as amyloid β. These shared markers suggest a potential mechanistic link between OPP exposure and AD pathology. In this review, we attempt to address the role of OPPs on altered cell physiology of the brain cells leading to neuroinflammation, mitochondrial dysfunction, and oxidative stress linked with AD pathogenesis.

show abstract

Section: Opps-induced Micro-rna (Mirna) Dysregulation: Unveiling the ...mentioning

confidence: 99%