The aim of the study is the formalization of the balance method with respect to the determination of the ecological and economic efficiency of the use of land resources. During the research, the following methods were used: statistical-economic, monographic, balance, computational and constructive. In the sphere of environmental protection, there is usually uncertainty about benefits and uncertainty about costs. Therefore, at the moment, further formalization of the assessment of the processes taking place in the system of interaction between man and land in the process of agricultural production is required. When analyzing the effectiveness of the use of agricultural land, it is important to determine not only economic, but also environmental and economic components. The ecological component of land use can be measured on the strength of the amount of prevented environmental damage applied to soil fertility, and the magnitude of the ecological effect that is created when carrying out measures to reproduce soil fertility. As the studies show, cultivating agricultural crops causes a negative balance of nutrients in the soil, and the calculation of environmental and economic efficiency indicates the need not only for joint application of organic and mineral fertilizers in optimal parameters, but also for finding alternative ways of ensuring reproduction of soil fertility.