2022
DOI: 10.1093/infdis/jiab606
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Understanding the Potential Drivers for Respiratory Syncytial Virus Rebound During the Coronavirus Disease 2019 Pandemic

Abstract: Non-pharmaceutical interventions (NPIs) were widely introduced to combat the COVID-19 pandemic. These interventions also likely led to substantially reduced activity of respiratory syncytial virus (RSV). From late 2020, some countries observed out-of-season RSV epidemics. Here, we analyzed the role of NPIs, population mobility, climate, and SARS-CoV-2 circulation in RSV rebound through a time-to-event analysis across 18 countries. Full (re)-opening of schools was associated with an increased risk for RSV rebou… Show more

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Cited by 71 publications
(72 citation statements)
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“…In particular, meteorological factors may be correlated with RSV activity and to NPIs stringency level via COVID-19 transmission. Not accounting for meteorological factors could have biased the models estimates.However, in a recent study that included meteorological factors, the risk of RSV rebound in the 10 weeks that followed full reopening of schools was significantly increased (hazard ratio = 23 [95% CI: 1-496]) 32. Overall, we described the patterns of the first RSV epidemic during the COVID-19 pandemic in 11 countries.…”
mentioning
confidence: 67%
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“…In particular, meteorological factors may be correlated with RSV activity and to NPIs stringency level via COVID-19 transmission. Not accounting for meteorological factors could have biased the models estimates.However, in a recent study that included meteorological factors, the risk of RSV rebound in the 10 weeks that followed full reopening of schools was significantly increased (hazard ratio = 23 [95% CI: 1-496]) 32. Overall, we described the patterns of the first RSV epidemic during the COVID-19 pandemic in 11 countries.…”
mentioning
confidence: 67%
“…Not accounting for meteorological factors could have biased the models estimates. However, in a recent study that included meteorological factors, the risk of RSV rebound in the 10 weeks that followed full reopening of schools was significantly increased (hazard ratio = 23 [95% CI: 1–496]) 32 …”
Section: Discussionmentioning
confidence: 99%
“…Altered patterns of RSV circulation were also seen in the Southern Hemisphere 1 , and the RSV season still seems to be aberrant in the Northern Hemisphere in the spring–summer of 2022. NPIs have affected RSV transmission by increasing the number of children that are naive for RSV and reducing community levels of immunity against RSV 2 . The lack of RSV circulation in the population during the SARS-CoV-2 pandemic might also have resulted in reduced transfer of passive immunity from mothers to their infants.…”
mentioning
confidence: 99%
“…Immunity against reinfection with RSV has been estimated to last from 7 months ( Arenas et al, 2009 ) to more than a year ( Pan-Ngum et al, 2017 ), further complicated by partial heterologous immune evasion by its subtypes A and B ( Human et al ,). Seasonal changes in climatic conditions can alter RSV’s effective transmissibility, modulated further by the concurrent change in interpersonal contact patterns shaping human to human transmission; however, the extent to which this pre-determines the timing of RSV seasons is largely unknown ( Pitzer et al, 2015 ) with the off-season resurgence of RSV in Europe and elsewhere in 2021 ( Li et al, 2022b , Eden et al, 2022 ) highlighting the potential for out of season spread.…”
Section: Introductionmentioning
confidence: 99%