Background: While evidence has shown an association between place of birth and birth outcomes, factors contributing to the choice of home birth have not been adequately investigated. In Tanzania more than 30% of deliveries occur out of health facilities with more than 95% of those deliveries are assisted by non-medical providers who are often unskilled. Birth assisted by unskilled birth attendants has been cited as a contributing factor for the high maternal and neonatal mortalities in low-resources countries. This study aimed at identifying determinants of choice for home birth over health facilities in Tanzania.Method: This study used the 2015-16 Tanzania Demographic and Health Survey and Malaria Indicator Survey (2015-16 TDHS-MIS) dataset. A total of 2286 women of reproductive age (15-49 years) who gave birth within one year preceding the survey were included in the analysis. Both univariate and multivariable regression analyses were used to determine predictors for the choice of home-based childbirth over health facility.Results: A total of 805 (35.2%) women had a home birth. After adjusting for confounders, the determinants for choice of home birth were the level of education [primary education, (AOR=0.666; p=0.001); secondary and higher education, (AOR=0.417; p<0.001)]in reference to no formal education; not owning a mobile phone, (AOR= 1.312; p=0.018); parity [parity 2-4, (AOR=1.594; p=0.004); parity 5 and above, (AOR=2.158; p<0.001)] in reference to parity 1; inadequate antenatal visits, (AOR=1.406; p=0.001); wealth index [poorest, (AOR=9.395; p<0.001); poorer, (AOR=7.701; p<0.001); middle, (AOR=5.961; p<0.001); richer, (AOR=2.557; p<0.001)] in reference to richest women and zones [Southern Highlands, (AOR=0.189; p<0.001); Southern, (AOR=0.225; p<0.001); Zanzibar, (AOR=2.55; p<0.001)] in reference to Western zone.Conclusion: A large proportion of women birth at home. Unskilled providers such as traditional birth attendants (TBAs), relatives or friends attend most of them. Predictors for home-based childbirth were lack of formal education, poor access to communication, poor uptake of antenatal visits, low socio-economic status, and geographical zone. Innovative strategies targeting these groups are needed to increase the use of health facilities for childbirth, thereby reducing maternal and neonatal mortality in Tanzania.