Understanding the preterm human heart: What do we know so far?

Schuermans, Art; Lewandowski, Adam J.

doi:10.1002/ar.24875

Cited by 22 publications

(18 citation statements)

References 130 publications

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“…Although the birth rate is low among advanced countries, premature infants (defined as delivery at <32 weeks of gestational age) are more likely to suffer from respiratory distress syndrome, sepsis, intraventricular hemorrhage, and necrotizing enterocolitis shortly after birth [ 1 , 2 ]. Furthermore, several studies have reported that an increase in the frequency of chronic diseases such as diabetes, obesity, cardiovascular diseases, and hypertensive disorders in adulthood can be attributed to an influence of the intrauterine environment and preterm birth [ 3 , 4 , 5 , 6 , 7 ]. Additionally, preterm birth is associated with elevated cardiovascular morbidity and mortality in adulthood [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, several studies have reported that an increase in the frequency of chronic diseases such as diabetes, obesity, cardiovascular diseases, and hypertensive disorders in adulthood can be attributed to an influence of the intrauterine environment and preterm birth [ 3 , 4 , 5 , 6 , 7 ]. Additionally, preterm birth is associated with elevated cardiovascular morbidity and mortality in adulthood [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although antenatal GC administration has been verified for lung development, its potential effects on other organs are debatable. Several reports have shown that antenatal GC treatment is beneficial for cardiovascular development [ 6 , 23 , 24 , 25 , 26 ]. Furthermore, preterm fetal exposure to maternal GCs accelerates cardiovascular maturation, improves basal cardiovascular function, and enhances fetal cardiovascular defense against physiological stress in extrauterine life [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antenatal Glucocorticoid Administration Promotes Cardiac Structure and Energy Metabolism Maturation in Preterm Fetuses

Sakurai

Takeba

Osada

et al. 2022

IJMS

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Although the rate of preterm birth has increased in recent decades, a number of preterm infants have escaped death due to improvements in perinatal and neonatal care. Antenatal glucocorticoid (GC) therapy has significantly contributed to progression in lung maturation; however, its potential effects on other organs remain controversial. Furthermore, the effects of antenatal GC therapy on the fetal heart show both pros and cons. Translational research in animal models indicates that constant fetal exposure to antenatal GC administration is sufficient for lung maturation. We have established a premature fetal rat model to investigate immature cardiopulmonary functions in the lungs and heart, including the effects of antenatal GC administration. In this review, we explain the mechanisms of antenatal GC actions on the heart in the fetus compared to those in the neonate. Antenatal GCs may contribute to premature heart maturation by accelerating cardiomyocyte proliferation, angiogenesis, energy production, and sarcoplasmic reticulum function. Additionally, this review specifically focuses on fetal heart growth with antenatal GC administration in experimental animal models. Moreover, knowledge regarding antenatal GC administration in experimental animal models can be coupled with that from developmental biology, with the potential for the generation of functional cells and tissues that could be used for regenerative medical purposes in the future.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antenatal Glucocorticoid Administration Promotes Cardiac Structure and Energy Metabolism Maturation in Preterm Fetuses

Sakurai

Takeba

Osada

et al. 2022

IJMS

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“…The transition from a prenatal to postnatal environment at birth is believed to be a critical step in CM development and transition to an adult state. One aspect that is worthy of consideration is how this process is affected in preterm birth scenarios (with a global prevalence of more than 10% of live births) and how an unprepared heart adapts to the sudden unexpected environmental change and interruption of a critical phase in CM maturation ( 102 ). This is of interest since the transcriptomic analysis of hiPSC-CMs indicate the limitation of current CM differentiation strategies in which CM s resemble the first trimester fetal heart which further may progress to around the equivalent of a second trimester fetal heart upon maturation treatment ( 103 ).…”

Section: The Impact Of Preterm Birth On Cardiomyocyte Maturationmentioning

confidence: 99%

Using human induced pluripotent stem cell-derived cardiomyocytes to understand the mechanisms driving cardiomyocyte maturation

Hamledari

Asghari

Jayousi

et al. 2022

Front. Cardiovasc. Med.

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Cardiovascular diseases are the leading cause of mortality and reduced quality of life globally. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide a personalized platform to study inherited heart diseases, drug-induced cardiac toxicity, and cardiac regenerative therapy. However, the immaturity of CMs obtained by current strategies is a major hurdle in utilizing hiPSC-CMs at their fullest potential. Here, the major findings and limitations of current maturation methodologies to enhance the utility of hiPSC-CMs in the battle against a major source of morbidity and mortality are reviewed. The most recent knowledge of the potential signaling pathways involved in the transition of fetal to adult CMs are assimilated. In particular, we take a deeper look on role of nutrient sensing signaling pathways and the potential role of cap-independent translation mediated by the modulation of mTOR pathway in the regulation of cardiac gap junctions and other yet to be identified aspects of CM maturation. Moreover, a relatively unexplored perspective on how our knowledge on the effects of preterm birth on cardiovascular development can be actually utilized to enhance the current understanding of CM maturation is examined. Furthermore, the interaction between the evolving neonatal human heart and brown adipose tissue as the major source of neonatal thermogenesis and its endocrine function on CM development is another discussed topic which is worthy of future investigation. Finally, the current knowledge regarding transcriptional mediators of CM maturation is still limited. The recent studies have produced the groundwork to better understand CM maturation in terms of providing some of the key factors involved in maturation and development of metrics for assessment of maturation which proves essential for future studies on in vitro PSC-CMs maturation.

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“…Other studies using cardiovascular magnetic resonance imaging (CMR) demonstrate that preterm-born adults have anatomical differences compared with those born at term, namely smaller ventricles and altered myocardial mass, with increased myocardial fibrosis, leading to impaired function (see Ref. [47] for a review). This cardiac phenotype could interact with higher blood pressures and physiological stress to accelerate progression of cardiovascular disease, but longer-term longitudinal studies are required to confirm this trajectory.…”

Section: Cardiovascular and Metabolic Outcomesmentioning

confidence: 99%