Understanding the Relationship Between Asthma and Sleep in the Pediatric Population

Banasiak, Nancy Cantey

doi:10.1016/j.pedhc.2015.11.012

Cited by 20 publications

(15 citation statements)

References 33 publications

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“…Increased inflammation and airway resistance affects the airways and causes decreased airway flow rates during sleep. Increased bronchial hyper-reactivity during sleep may be related to allergen exposure, airway cooling, hormonal changes, and parasympathetic tone [38,39]. These mechanisms provide evidences that poor asthma control and concomitant presence of rhinitis are associated with high risk for SDB in children [12].…”

Section: Discussionmentioning

confidence: 98%

Characteristics and risk factors of children with sleep-disordered breathing in Wuxi, China

et al. 2020

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Background: Sleep-disordered breathing (SDB) is a common syndrome in children, related to their immune responses, cardiovascular function, and neurocognitive function. This study aimed to determine the prevalence of SDB among children in Wuxi, China, and to evaluate the protective and risk factors of SDB in children. Methods: A cross-sectional study was conducted on children attending different schools across Wuxi, China, aged 3-14 years old. Of a total of 5630 questionnaires distributed to the parents of the children, 3997 (71.0%) were deemed to be valid. The data on the general sociodemographic factors, children's allergy and sleep characteristics, and the parents' sleep characteristics were also collected. The Paediatric Sleep Questionnaire (PSQ) score was used to identify children at high risk of SDB. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression. Results: The prevalence of SDB in this cohort was 13.4% (N = 534). SDB prevalence significantly differed in children with asthma (28.2% vs. 12.8%, P < 0.001), eczema (19.0% vs. 10.0%, P < 0.001), urticaria (16.4% vs. 12.9%, P < 0.01) and rhinitis (21.4% vs. 10.7%, P < 0.001). No significant differences were found in SDB prevalence with respect to pillow material or quilt material. On multivariate logistic regression analysis, asthma (OR 1.986 (95% CI 1.312-3.007), P < 0.01), eczema (OR 1.675 (95% CI 1.377-2.037), P < 0.001), rhinitis (OR 1.998 (95% CI 1.635-2.441), suffered from familial sleep sickness (OR 2.416 (95% CI 1.975-2.955), P < 0.001) and whose mothers slept for a shorter duration (6 h-8 h: OR 1.370 (95% CI 1.089-1.724), P < 0.01; <6 h: OR 3.385(95% CI 2.098-5.461), P < 0.001) increased the odds of having SDB. The incidence of SDB significantly decreased with children's age (6-11 years old: 0R 0.768 (95% CI 0.597-0.989), P < 0.05; 12-14 years old: OR 0.691 (95% CI 0.530-0.901), P < 0.01). Conclusion: The results of this study demonstrated that atopic diseases (asthma, eczema, and rhinitis) and family sleep habits were risk factors for SDB in children in Wuxi, China.

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Section: Discussionmentioning

confidence: 98%

Characteristics and risk factors of children with sleep-disordered breathing in Wuxi, China

et al. 2020

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“…However, for the evaluation of large numbers of patients this approach is impractical. Consequently, there is a necessity for an automated/ objective evaluation of respiratory symptoms [20].…”

Section: Discussionmentioning

confidence: 99%

“…Asthmatic children and adolescents are more likely to show impaired daytime performance compared to healthy controls [22][23][24][25]. Night-time asthma results in poorer sleep quality that can also have adverse effects on their efficiency during daytime [20,26]. Reports of children symptoms are often inaccurate or unusable and therefore it becomes essential to objectify respiratory symptoms such as coughing and wheezing, especially during sleep.…”

Section: Discussionmentioning

confidence: 99%

Disease control in patients with asthma and respiratory symptoms (wheezing, cough) during sleep

Doenges

Kuckuck

Cassel

et al. 2020

asthma res and pract

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Introduction The Global Initiative for Asthma (GINA)-defined criteria for asthma control include questions about daytime symptoms, limitation of activity, nocturnal symptoms, need for reliever treatment and patients’ satisfaction. Patients with nocturnal symptoms like wheezing and cough often suffer from lower sleep quality and impaired daytime performance. The lack of an appropriate method for standardized and objective monitoring of respiratory symptoms leads to difficulties in asthma management. The aim of this study is to present a new method for automated wheeze and cough detection during sleep and to assess the actual level of asthma control by the Asthma Control Test (ACT). Methods Respiratory symptoms like wheezing and cough were recorded with the LEOSound-Monitor for one night in 55 asthmatic patients in their individual domestic setting. Patients were asked to assess their level of asthma subjectively with the ACT. The study consisted of 37 women and 18 men, with a mean age of 41 years, and a mean BMI of 27 kg/m2. Most of the patients had been taking an ICS/LABA combination and would resort to a SABA as their rescue medication. Results 60% of the participants were classed as having controlled, and 40% were classed as having partially- or uncontrolled asthma. During sleep wheezing was found in 8 of the 55 asthma patients (14.5%) and coughing was found in 30 patients (54.5%). The median ACT score in wheezing-patients was 14, while in non-wheezing patients it was 21. Uncontrolled asthma was found in 6 of the 8 wheezing-patients. Coughing versus non-coughing patients did not show a significant difference in the ACT-score (20, 22 respectively). Conclusion Wheezing is a sign of uncontrolled asthma. The ACT-score in wheezing patients is worse compared to patients without wheezing. LEOSound proofed to be a useful tool in providing an objective evaluation of respiratory symptoms, like coughing and wheezing. In clinical practice, this may allow an improvement in asthma therapy.

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“…It contains five items in each of four subscales: emotional problems, hyperactivity/inattention, conduct problems and peer problems. Each item is scored on a three-point scale; ‘Not true’ (0), ‘Somewhat true’1 and ‘Certainly true’ 2. The total subscale score ranges from 0 to 10 and the total score from 0 to 40.…”

Section: Methodsmentioning

confidence: 99%

“…Sleep is critical for development, maturation and health on the journey from infancy to adulthood 1. Sleep problems in children have been associated with asthma and other respiratory symptoms,2 and with mental health problems, such as conduct problems, hyperactivity and emotional problems 3–5. Children with neurological disabilities often have sleep problems,6 but somatic and mental comorbidities may contribute to these problems 7–9…”

Section: Introductionmentioning

confidence: 99%

Sleep problems, behavioural problems and respiratory health in children born extremely preterm: a parental questionnaire study

Stangenes

Hysing

Elgen

et al. 2019

bmjpo

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ObjectiveTo explore whether children born extremely preterm (EPT) with different types of sleep problems had more behavioural and respiratory health problems than EPT children without sleep problems.DesignProspective, nationwide, questionnaire-based study. At 11 years of age, parents reported on four current sleep problems: difficulty falling asleep or frequent awakenings, snoring, daytime sleepiness and not recommended sleep duration (<9 hours). Behavioural problems were assessed by parents and teachers with the Strengths and Difficulties Questionnaire (SDQ). Parents assessed respiratory symptoms with the International Study of Asthma and Allergies in Childhood questionnaire and described use of asthma medication.SettingNorway.PatientsEPT children.Main outcome measuresSpecified sleep problems, behavioural problems and respiratory health.ResultsData were obtained from 216 of 372 (58 %) of eligible children. All four specified sleep problems were associated with significantly higher parent-reported SDQ total-score (OR 1.1 for all), and except for not recommended sleep duration, also with higher teacher-reported SDQ total-score (OR 1.1 for all). Daytime sleepiness was strongly associated with wheezing last 12 months (OR 3.4), disturbed sleep due to wheezing (OR 3.9), wheeze during or after exercise (OR 2.9), use of inhaled corticosteroids or oral leukotriene modifiers (OR 3.4) and use of bronchodilators (OR 3.9). Snoring was associated with wheezing during or after exercise (OR 2.8) and current asthma (OR 4.2).ConclusionEPT children with different types of sleep problems had more behavioural and respiratory health problems than EPT children without sleep problems.

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Understanding the Relationship Between Asthma and Sleep in the Pediatric Population

Cited by 20 publications

References 33 publications

Characteristics and risk factors of children with sleep-disordered breathing in Wuxi, China

Characteristics and risk factors of children with sleep-disordered breathing in Wuxi, China

Disease control in patients with asthma and respiratory symptoms (wheezing, cough) during sleep

Sleep problems, behavioural problems and respiratory health in children born extremely preterm: a parental questionnaire study

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