Understanding the relationship between viral infections and trace elements from a metallomics perspective: implications for COVID-19

Jesus, Jemmyson Romário de; Andrade, Tatianny de Araújo

doi:10.1039/d0mt00220h

Cited by 27 publications

(50 citation statements)

References 185 publications

(209 reference statements)

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“…Computational analysis has indicated that Zn-binding and Mn-binding domains are prevalent in viral proteomes and that many viral metal-binding proteins target host metal homeostasis regulators ( 227 ). The relevance of metal ions to the immune response to the SARS-CoV2—a cause of an unprecedented COVID-19 pandemic—has been discussed recently ( 228 ). As such, serum Fe levels have been linked to mortality risk in SARS-CoV2 patients ( 229 , 230 ).…”

Section: Adapting To Changes In Metal Availabilitymentioning

confidence: 99%

Interchangeable utilization of metals: New perspectives on the impacts of metal ions employed in ancient and extant biomolecules

Smethurst

Shcherbik

2021

Journal of Biological Chemistry

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Metal ions provide considerable functionality across biological systems, and their utilization within biomolecules has adapted through changes in the chemical environment to maintain the activity they facilitate. While ancient earth's atmosphere was rich in iron and manganese and low in oxygen, periods of atmospheric oxygenation significantly altered the availability of certain metal ions, resulting in ion replacement within biomolecules. This adaptation mechanism has given rise to the phenomenon of metal cofactor interchangeability, whereby contemporary proteins and nucleic acids interact with multiple metal ions interchangeably, with different coordinated metals influencing biological activity, stability, and toxic potential. The ability of extant organisms to adapt to fluctuating metal availability remains relevant in a number of crucial biomolecules, including the superoxide dismutases of the antioxidant defense systems and ribonucleotide reductases. These well-studied and ancient enzymes illustrate the potential for metal interchangeability and adaptive utilization. More recently, the ribosome has also been demonstrated to exhibit interchangeable interactions with metal ions with impacts on function, stability, and stress adaptation. Using these and other examples, here we review the biological significance of interchangeable metal ions from a new angle that combines both biochemical and evolutionary viewpoints. The geochemical pressures and chemical properties that underlie biological metal utilization are discussed in the context of their impact on modern disease states and treatments.

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Section: Adapting To Changes In Metal Availabilitymentioning

confidence: 99%

Interchangeable utilization of metals: New perspectives on the impacts of metal ions employed in ancient and extant biomolecules

Smethurst

Shcherbik

2021

Journal of Biological Chemistry

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“…Both trace element deficiency and excess lead to physiological disorders, and high metal concentrations can have toxic effects [10]. Trace elements play essential roles in the survival of the virus and the activation of the host's immune system [11]. For example, zinc (Zn) is antiviral against several viruses, necessary for the development of the immune system, and it inhibits the activity of the RNA-dependent RNA polymerase (RdRp) of the coronavirus [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Trace Element Levels and Biochemical Parameters of COVID-19 Patients According to Disease Severity

Koçak

Özgeriş

Parlak

et al. 2021

Biol Trace Elem Res

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While the COVID-19 disease progresses mildly or asymptomatically in some people, its progression is severe and symptomatic in others, and it is an issue that requires a scientific response regarding the disease. The present study includes 60 people infected with COVID-19, and the cases were divided into the following groups: asymptomatic, mild, moderate, and severe. Serum Zn, Se, and Cu levels of these groups were analyzed by ICP-MS. All measurements in the patients were compared with those of 32 healthy individuals. When the patient group is compared with the control group, the serum Zn and Se concentrations were statistically low ( p < 0.001) in the patient group. Serum Zn level decreased significantly in 4 different patient groups compared to the control group. Although the serum Se level decreased in all four patient groups compared to the control group, the change in Se level was statistically significant only in the severe and mild patient groups. This study examined serum Zn, Se concentrations, and biochemical parameters in patients with different severity of COVID-19, compared them with healthy individuals, and revealed new targets for diagnosis and treatment by revealing those data that may be important.

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“…It has also been shown that supplementation with vitamin D is a good preventive strategy in recurring respiratory tract infections [3] and also COVID-19 infections [20]. Furthermore, there is mounting evidence to suggest that balanced zinc, selenium, and vitamin C levels prevent viral respiratory infections [35][36][37][38][39][40]. Zinc is a dietary trace mineral that boosts immune cells [41].…”

Section: Introductionmentioning

confidence: 99%

Dietary Intake and Mental Health among Saudi Adults during COVID-19 Lockdown

Alfawaz

Yakout

Wani

et al. 2021

IJERPH

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The study aimed to explore the influence of the COVID-19 lockdown on the mental status and dietary intake of residents in Saudi Arabia. In this cross-sectional study, an online survey was conducted from 11 May to 6 June 2020 corresponding to almost two weeks during and after Ramadan (23 April–23 May 2020). The Patient Health Questionnaire was used to assess anxiety, depression, and insomnia. Logistic regression analysis was used to identify predictors of anxiety, depression, and insomnia. The prevalence of anxiety, depression, and insomnia among the participants was 25.4%, 27.7%, and 19.6%, respectively. Participants aged ≥50 years with high income (≥8000 SAR) were at a lower risk of developing depression, whereas participants of the same age group with income 5000–7000 SAR were at high risk of developing anxiety. Students and master-educated participants suffer from median elevated depression and are required to take more multivitamins and vitamin D than others. Anxiety and depression were more common among married participants with low income. There is a wide range of Saudi residents who are at a higher risk of mental illness during the COVID-19 pandemic. Policymakers and mental healthcare providers are advised to provide continuous monitoring of the psychological consequences during this pandemic and provide mental support.

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Understanding the relationship between viral infections and trace elements from a metallomics perspective: implications for COVID-19

Abstract: Recently, the World Health Organization (WHO) declared a pandemic situation due to a new viral infection (COVID-19) caused by a novel virus (Sars-CoV-2). COVID-19 is today the leading cause of...

Cited by 27 publications

References 185 publications

Interchangeable utilization of metals: New perspectives on the impacts of metal ions employed in ancient and extant biomolecules

Interchangeable utilization of metals: New perspectives on the impacts of metal ions employed in ancient and extant biomolecules

Evaluation of Serum Trace Element Levels and Biochemical Parameters of COVID-19 Patients According to Disease Severity

Dietary Intake and Mental Health among Saudi Adults during COVID-19 Lockdown

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