2024
DOI: 10.1063/5.0206341
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Understanding the role of B cells in CAR T-cell therapy in leukemia through a mathematical model

Sergio Serrano,
Roberto Barrio,
Álvaro Martínez-Rubio
et al.

Abstract: Chimeric antigen receptor T (CAR T) cell therapy has been proven to be successful against a variety of leukemias and lymphomas. This paper undertakes an analytical and numerical study of a mathematical model describing the competition of CAR T, leukemia, tumor, and B cells. Considering its significance in sustaining anti-CD19 CAR T-cell stimulation, a B-cell source term is integrated into the model. Through stability and bifurcation analyses, the potential for tumor eradication, contingent on the continuous in… Show more

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Cited by 4 publications
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