Understanding the role of dogs (Canis lupus familiaris) in the transmission dynamics of Trypanosoma cruzi genotypes in Colombia

Ramírez, Juan David; Turriago, Brenda; Tapia-Calle, Gabriela; Guhl, Felipe

doi:10.1016/j.vetpar.2012.12.054

Cited by 53 publications

(49 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…16 The observation of T. cruzi in 8.3% of the dogs examined, although much lower than the prevalence found in Venezuela and Panama, 17,18 is similar to that found in dogs inhabiting dwellings with domiciliary triatomines in endemic areas of the Andes zone in Colombia. 19,20 Trypanosoma cruzi I isolated in triatomines and mammals in this study is the discrete typing unit most frequently found in Colombia and in R. prolixus in this region and is associated with severe cardiopathy in Colombia and Argentina. 21 The presence of infected people, the high domiciliary infestation by permanent intrusion of infected adult specimens of R. prolixus from highly infested peridomiciliary palms, and the identification of domestic and wild hosts as a common food source in palm and intradomiciliary triatomines and in infected dogs in the dwellings support the extension of the wild cycle of T. cruzi to human domiciles.…”

mentioning

confidence: 68%

Human Trypanosomiasis in the Eastern Plains of Colombia: New Transmission Scenario

Angulo-Silva

Castellanos-Domínguez

Flórez-Martínez

et al. 2016

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. Characteristics of Trypanosoma cruzi infection were studied in a rural area of the eastern plains of Colombia. Using enzyme-linked immunosorbent assay and indirect fluorescent-antibody tests, the infection was determined in 11.6% of the inhabitants of 142 dwellings. During 6 months of community surveillance, in 42.3% dwellings, 609 triatomines were collected (597 Rhodnius prolixus and seven, three, one, and one of Panstrongylus geniculatus, Psammolestes arturi, Eratyrus mucronatus, and Triatoma maculata, respectively). Rhodnius prolixus was found in 80% peridomiciliary Attalea butyracea palms examined with baited traps, and its infection with T. cruzi was 30% and 38.5% in dwellings and palms, respectively. Trypanosoma cruzi was isolated in five of 35 triatomines and in one of 24 dogs. The blood of domestic and wild animals was identified in triatomines collected in the intradomicile and in palms. These results support the extension of the wild cycle of T. cruzi to human dwellings and the characterization of a new scenario for transmission in Colombia.Trypanosoma cruzi infection continues to affect nearly 6 million people in 21 countries of the Americas 1 despite the success of control programs against domestic triatomines. 2There are zones where dwellings are infested by other species of Triatominae with peridomiciliary and wild ecotopes. In the Amazon, some of the more than 27 wild species described, principally of the genus Rhodnius, have made incursions into dwellings, with the risk of infecting human populations. 3In Colombia, the Andean region in the eastern zone below 2,000 m above sea level has been considered endemic for Chagas disease because of the high degree of domiciliary infestation, wide dispersion, and the high densities of Rhodnius prolixus.4,5 A decade after the adoption of a government program to control domiciliary triatomines, in our observation, this species has been controlled. However, another transmission scenario has begun to be known with checking of the wild cycle in peridomiciliary palms as a transmission risk factor in the departments of the eastern plains 6 and the reporting of high prevalence rates of human infection with T. cruzi.7 This study was conducted for the purpose of clarifying the epidemiological characteristics of this scenario in this region.In December 2008, the prevalence of T. cruzi infection was evaluated in the inhabitants of 142 dwellings in the department of Casanare, dispersed in rural areas of the municipalities of Maní (04°49′02″N/72°17′19″W) and Aguazul (05°10′23″N/ 72°33′17″W), which were fumigated by the program of VectorTransmitted Diseases (Enfermedades Transmitidas por Vectores [ETV], in Spanish) in that department. This territory corresponds to the alluvial and eolic plains of the Orinoquía, composed of flooded savannas with herbaceous and graminaceous vegetation in the humid warm thermal floor, with an average temperature of 25-27°C and an annual rainfall of 2,400-2,600 mm (Figure 1).The dwellings are constructed with brick walls, cement, ti...

show abstract

mentioning

confidence: 68%

Human Trypanosomiasis in the Eastern Plains of Colombia: New Transmission Scenario

Angulo-Silva

Castellanos-Domínguez

Flórez-Martínez

et al. 2016

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…Infected dogs have been reported from the USA to southern Argentina and Chile, including areas with only sylvatic transmission cycles (e.g., USA, West Indies and the Amazon basin). All six T. cruzi DTUs were identified in dogs (Cardinal et al, 2008;Ramírez et al, 2013;Roellig et al, 2008). Prevalence rates of dog infection greater than 50% were recorded in several areas infested by T. infestans and R. prolixus, sometimes reaching or exceeding the local human infection rates, but dog prevalence more typically varied between 10% and 30%.…”

Section: Prevalence Of Infectionmentioning

confidence: 99%

“…Opossums, armadillos and rodents are major sylvatic reservoir hosts, whereas humans, dogs, cats and commensal (synanthropic) rodents are the main hosts in domestic or peridomestic (i.e., (peri)domestic) habitats (Jansen and Roque, 2010;Minter, 1976a;Noireau et al, 2009;WHO, 2002). Trypanosoma rangeli, another Trypanosomatidae infecting humans, dogs and other mammals through the bite (salivaria transmission) of triatomine bugs of the genus Rhodnius, is considered non-pathogenic for mammals and pathogenic for triatomines (Pifano, 1973;Pineda et al, 2011;Ramírez et al, 2013;Vallejo et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Reservoir host competence and the role of domestic and commensal hosts in the transmission of Trypanosoma cruzi

2015

View full text Add to dashboard Cite

“…Así, las diferencias sexuales en la susceptibilidad o resistencia a la infección no deben considerarse como una variable más, sino como un factor de riesgo importante en el desarrollo de las enfermedades infecciosas. Este aspecto es particularmente importante en relación a los perros que, junto a los gatos y roedores, son los principales hospederos de T. cruzi en los hábitats domésticos y peridomésticos (Ramírez et al, 2013;Gürtler y Cardinal, 2015).…”

Section: Discussionunclassified

“…T. cruzi se asocia generalmente a la población humana, pero también puede encontrarse en diversas especies animales, tanto silvestres como domésticas (Gürtler y Cardinal, 2015). Así, el parásito puede encontrase de manera natural en perros, gatos, bovinos, cabras, ovejas, conejos, cerdos, equinos y, desde el punto de vista veterinario, se requiere establecer el rol de estas especies en la epidemiología de la enfermedad, así como su papel como reservorios naturales del agente causante de esta compleja zoonosis (Ramírez et al, 2013).…”

Section: Introductionunclassified

Daño Cardiaco en Ratones Ovariectomizados y Experimentalmente Infectados con Trypanosoma cruzi

Herrera

González

Marti

et al. 2017

Rev. investig. vet. Perú

View full text Add to dashboard Cite

En el presente trabajo se evaluó el daño tisular en el miocardio de ratones Balb/c ovariectomizadas y no ovariectomizadas y su relación con el número de seudoquistes y células inflamatorias mononucleares, y su asociación con niveles de parasitemia y mortalidad acumulada en el curso de la infección con 2000 tripomastigotes sanguíneos del clon Dm28c de T. cruzi. Las hembras ovariectomizadas mostraron una prepatencia sanguínea de 3 días y niveles de parasitemia más altos (p<0.001) durante los primeros 9 días pos-infección (p.i.), en comparación con las no ovariectomizadas que presentaron una prepatencia de 5 días. Sin embargo, el nivel máximo de parasitemia alcanzado por las ovariectomizadas (18.09 x 104 ± 1.66 x 104 parásitos/ml) a los 11 días p.i. fue más bajo (p<0.05) que el nivel máximo de 26.03 x 104 ± 1.83 x 104 parásitos/ml, alcanzado por las no ovariectomizadas a los 11 días p.i. El análisis histopatológico mostró una asociación entre el mayor parasitismo intracelular (seudoquistes), el elevado infiltrado inflamatorio mononuclear, la severidad del daño cardiaco y el 100% de mortalidad alcanzado por las hembras ovariectomizadas a los 21 días p.i., en comparación con los valores menores y el 70% de mortalidad alcanzado por las hembras no ovariectomizadas en el mismo periodo. Así, las diferencias sexuales en la susceptibilidad o resistencia a la infección no deberían considerarse como una variable más, sino como un factor de riesgo importante en el desarrollo de las enfermedades infecciosas.

show abstract

Understanding the role of dogs (Canis lupus familiaris) in the transmission dynamics of Trypanosoma cruzi genotypes in Colombia

Cited by 53 publications

References 18 publications

Human Trypanosomiasis in the Eastern Plains of Colombia: New Transmission Scenario

Human Trypanosomiasis in the Eastern Plains of Colombia: New Transmission Scenario

Reservoir host competence and the role of domestic and commensal hosts in the transmission of Trypanosoma cruzi

Daño Cardiaco en Ratones Ovariectomizados y Experimentalmente Infectados con Trypanosoma cruzi

Contact Info

Product

Resources

About