The concept of "poverty poisons the brain" has become a major area of research in neuroscience and the health sciences, and an increasingly utilized metaphor to argue for the importance of addressing inequality and poverty in the United States. This article systematically presents the research behind poverty poisons the brain, which includes the impact of socioeconomic status on human development, the developmental models used to understand how poverty impacts children, and the proximate social factors and brain mechanisms that represent the core causal model behind this research. This overview examines the uses of this research for neuroanthropology, highlighting the impact of inequality and how experience becomes embodied. Nevertheless, a simplistic cause-effect approach and the reduction of the social to the biological often hamper this type of research. A critical approach to how poverty poisons the brain provides the basis for making the shift to a more robust neuroanthropological approach to poverty. Neuroanthropology can utilize social embodiment, the dynamics of stress, and the production of inequality to transform research on poverty and children, and to make policy recommendations, do applied research, and craft and test interventions to deal with the pernicious impact of poverty. [poverty, human development, stress, inequality, critical theory] In February 2008, Paul Krugman, Nobel laureate economist and New York Times columnist, wrote an op-ed entitled, "Poverty Is Poison." He summarized research presented at the American Association for the Advancement of Science annual conference by Martha Farah, a University of Pennsylvania neuroscientist, and her colleagues. These data showed that "unhealthy" levels of stress hormones in poor children can harm neural development. Krugman then argued:The effect is to impair language development and memory-and hence the ability to escape poverty-for the rest of the child's life. So now we have another, even more compelling reason to be ashamed about America's record of failing to fight poverty [Krugman 2008].