Understanding the role of microperimetry in glaucoma

Scuderi, Luca; Gattazzo, Irene; Paula, Alessandro de; Iodice, Clemente Maria; Tizio, Federico Di; Perdicchi, Andrea

doi:10.1007/s10792-021-02203-3

Cited by 6 publications

(2 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Microperimetry showed high reproducibility compared with conventional perimetry [11] . In contrast, the SAP results of patients with unstable fixation were relatively unreliable, especially for detecting visual function in the macular area [12] . MP-3 offers correction of subject eye movements with built-in eye trackers to generate an accurate projection of light stimuli in a specific region to be examined [13] .…”

Section: Correlation Analysis Of Gcc and Mean Sensitivitymentioning

confidence: 92%

MP-3 microperimeter in early primary open angle glaucoma with a new pattern

Liang,

Liu,

Duan

et al. 2024

Int J Ophthalmol

View full text Add to dashboard Cite

AIM: To investigate macular microperimetry in patients with early primary open angle glaucoma (POAG) using a new custom-made pattern, and analyze the characteristics of macular sensitivity. METHODS: This case-control study included 38 patients with POAG, who were divided into pre-perimetric glaucoma (18 eyes of 18 patients), early-stage (20 eyes of 20 patients), and control (20 eyes of 20 patients) groups. All subjects underwent standard 24-2 humphrey visual field test. An MP-3 microperimeter with a new custom-made pattern (28 testing points distributed in four quadrants, covering the central 10° of the retina) was used to evaluate macular sensitivity. Ganglion cell complex (GCC) thicknesses were examined using an RS-3000 Advance OCT system. The features of structure and function were analysed per quadrant. RESULTS: The pre-perimetric glaucoma group had significantly lower inferior hemifield macular sensitivity compared to controls (P<0.05). The early-stage POAG group had significantly lower average, inferior hemifield, inferonasal, and inferotemporal mean sensitivities compared to the pre-perimetric glaucoma group (P<0.05), and lower macular sensitivity in all sectors compared to controls (P<0.05). Regarding GCC thickness, all sectors in the early-stage POAG group became thinner compared to those in controls (P<0.05); whereas all sectors in the early-stage POAG group, except the superonasal quadrant, became thinner compared to those in the pre-perimetric glaucoma group (P<0.05). Macular sensitivity and GCC thickness were significantly associated in each sector. The inferotemporal quadrant had the highest correlation coefficients (0.840). The structure-function relationship for the inferonasal and inferotemporal sectors was stronger compared to the corresponding superior sectors. CONCLUSION: Microperimetry reveals variations in macular sensitivity in patients with early glaucoma earlier than conventional perimetry, particularly in pre-perimetric glaucoma cases in which it might be undetectable by conventional methods. The new custom-made pattern may improve the accuracy of microperimetry by enhancing point arrangement and reducing fatigue effects. Macular sensitivity measured by MP-3 with this pattern shows statistically significant structural and functional associations with the thicknesses of the GCC.

show abstract

Section: Correlation Analysis Of Gcc and Mean Sensitivitymentioning

confidence: 92%

MP-3 microperimeter in early primary open angle glaucoma with a new pattern

Liang,

Liu,

Duan

et al. 2024

Int J Ophthalmol

View full text Add to dashboard Cite

show abstract

“…Microperimetry (MP) is another important visual function assay that produces retinal sensitivity results comparable to standard automated perimetry but also has better anatomical-functional correspondence. 17,18 Additionally, MP can effectively detect residual visual function in various ophthalmic conditions such as glaucoma, DR and AMD. [19][20][21] In their review, Midena et al also concluded that MP was superior in providing functional changes than VA in patients with AMD.…”

Section: Age-related Macular Degenerationmentioning

confidence: 99%

Predictive Deep Learning Applications in Ophthalmology

Koseoglu,

Liu

2023

touchREVIEWS in Ophthalmology

View full text Add to dashboard Cite

Therapies for retinal diseases have witnessed remarkable progress, particularly in the domain of drug delivery routes. Intravitreal injections have especially revolutionized the treatment landscape for various proliferative retinopathies. The emergence of suprachoroidal space as a novel drug delivery site is poised to overcome challenges seen in optimizing drug penetration, targeting, and bioavailability. This approach holds promise for delivering various agents, including steroids, anti-vascular endothelial growth factor molecules, gene vectors, and small molecules, with multiple clinical trials demonstrating this delivery method's potential to reduce treatment burdens and optimize visual outcomes. Particularly, small molecule therapy for retinal diseases finds ease of application through the suprachoroidal route in that small molecule agents have a wide range of targets in disease pathway, greater tissue penetration, and cost-effectiveness in production. The suprachoroidal administration of axitinib, a tyrosine kinase inhibitor, has shown promise in the OASIS trial for treating neovascular age-related macular degeneration. Integrin antagonists and plasma Kallikrein-kinin system inhibitors, also delivered suprachoroidally, exhibit targeted distribution and potential for long-acting therapy.

show abstract